On the induction of postsynaptic granule cell-Purkinje neuron LTP and LTD

Vogt, Kaspar E. and Canepari, Marco. (2010) On the induction of postsynaptic granule cell-Purkinje neuron LTP and LTD. The Cerebellum, Vol. 9. pp. 284-290.

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Official URL: http://edoc.unibas.ch/dok/A5847377

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In the last decade, several experimental studies have demonstrated that particular patterns of synaptic activity can induce postsynaptic parallel fiber (PF) long-term potentiation (LTP). This form of plasticity can reverse postsynaptic PF long-term depression (LTD), which has been traditionally considered as the principal form of plasticity underlying cerebellar learning. Postsynaptic PF-LTP requires a transient increase in intracellular Ca(2+) concentration and, in contrast to PF-LTD, is induced without concomitant climbing fiber (CF) activation. Thus, it has been postulated that the polarity of long-term synaptic plasticity is determined by the amplitude of the Ca(2+) transient during the induction protocol, with PF-LTP induced by smaller Ca(2+) signals without concomitant CF activation. However, this hypothesis is contradicted by recent studies. A quantitative analysis of Ca(2+) signals associated with induction of PF-LTP indicates that the bidirectional induction of long-term plasticity is regulated by more complex mechanisms. Here we review the state-of-the-art of research on postsynaptic PF-LTP and PF-LTD and discuss the principal open questions on this topic.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Vogt)
03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Pharmakologie (Vogt)
UniBasel Contributors:Vogt, Kaspar
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Martin Dunitz
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 Jun 2013 12:28
Deposited On:08 Jun 2012 06:46

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