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Natural products in drug discovery –concepts and approaches for tracking bioactivity

Potterat, O. and Hamburger, M.. (2006) Natural products in drug discovery –concepts and approaches for tracking bioactivity. Current Organic Chemistry, Vol. 10, No. 8. pp. 899-920.

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Official URL: http://edoc.unibas.ch/dok/A5841060

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Abstract

Effective methods for localization and characterization of bioactivity are a cornerstone for natural product based drug discovery efforts. Over the last decade, a wealth of new technologies and conceptual approaches for bioactivity screening have emerged. These developments are reviewed under the perspective of their applicability in the field of natural products discovery. The methods discussed here include bioautography, HPLC-based activity profiling, HPLC-based on-flow bioassays, assays based on capillary electrophoresis, molecular imprinted polymers, various MS- and NMR-based methods, biosensors, and chip-based technologies for affinity separation and expression profiling. Selected examples illustrate the potential and limitations of the different approaches for contemporary natural products lead discovery.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Biologie (Hamburger)
UniBasel Contributors:Potterat, Olivier
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Bentham Science Publishers
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:08 Jun 2012 06:55
Deposited On:08 Jun 2012 06:45

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