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Two-dimensional crystals : a powerful approach to assess structure, function and dynamics of membrane proteins

Stahlberg, H. and Fotiadis, D. and Scheuring, S. and Rémigy, H. and Braun, T. and Mitsuoka, K. and Fujiyoshi, Y. and Engel, A.. (2001) Two-dimensional crystals : a powerful approach to assess structure, function and dynamics of membrane proteins. FEBS letters, Vol. 504, H. 3. pp. 166-172.

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Official URL: http://edoc.unibas.ch/dok/A5262383

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Abstract

Electron crystallography and atomic force microscopy allow the study of two-dimensional membrane protein crystals. While electron crystallography provides atomic scale three-dimensional density maps, atomic force microscopy gives insight into the surface structure and dynamics at sub-nanometer resolution. Importantly, the membrane protein studied is in its native environment and its function can be assessed directly. The approach allows both the atomic structure of the membrane protein and the dynamics of its surface to be analyzed. In this way, the function-related conformational changes can be assessed, thus providing a detailed insight on the molecular mechanisms of essential biological processes.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Stahlberg)
UniBasel Contributors:Stahlberg, Henning
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier Science
ISSN:0014-5793
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:55
Deposited On:08 Jun 2012 06:44

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