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Case-control genome-wide association study of attention-deficit/hyperactivity disorder

Neale, Benjamin M. and Medland, Sarah and Ripke, Stephan and Anney, Richard J. L. and Asherson, Philip and Buitelaar, Jan and Franke, Barbara and Gill, Michael and Kent, Lindsey and Holmans, Peter and Middleton, Frank and Thapar, Anita and Lesch, Klaus-Peter and Faraone, Stephen V. and Daly, Mark and Nguyen, Thuy Trang and Schäfer, Helmut and Steinhausen, Hans-Christoph and Reif, Andreas and Renner, Tobias J. and Romanos, Marcel and Romanos, Jasmin and Warnke, Andreas and Walitza, Susanne and Freitag, Christine and Meyer, Jobst and Palmason, Haukur and Rothenberger, Aribert and Hawi, Ziarih and Sergeant, Joseph and Roeyers, Herbert and Mick, Eric and Biederman, Joseph and Image II Consortium Group, . (2010) Case-control genome-wide association study of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 49 (9). pp. 906-920.

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Official URL: http://edoc.unibas.ch/dok/A5839884

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Abstract

OBJECTIVE: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. Thus additional genomewide association studies (GWAS) are needed. METHOD: We used case-control analyses of 896 cases with DSM-IV ADHD genotyped using the Affymetrix 5.0 array and 2,455 repository controls screened for psychotic and bipolar symptoms genotyped using Affymetrix 6.0 arrays. A consensus SNP set was imputed using BEAGLE 3.0, resulting in an analysis dataset of 1,033,244 SNPs. Data were analyzed using a generalized linear model. RESULTS: No genome-wide significant associations were found. The most significant results implicated the following genes: PRKG1, FLNC, TCERG1L, PPM1H, NXPH1, PPM1H, CDH13, HK1, and HKDC1. CONCLUSIONS: The current analyses are a useful addition to the present literature and will make a valuable contribution to future meta-analyses. The candidate gene findings are consistent with a prior meta-analysis in suggesting that the effects of ADHD risk variants must, individually, be very small and/or include multiple rare alleles.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0890-8567
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Jun 2018 10:28
Deposited On:08 Jun 2012 06:44

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