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ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype

Hawi, Z. and Kent, L. and Hill, M. and Anney, R. J. L. and Brookes, K. J. and Barry, E. and Franke, B. and Banaschewski, T. and Buitelaar, J. and Ebstein, R. and Miranda, A. and Oades, R. D. and Roeyers, H. and Rothenberger, A. and Sergeant, J. and Sonuga-Barke, E. and Steinhausen, H.-C. and Faraone, S. V. and Asherson, P. and Gill, M.. (2009) ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype. American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 150B, H. 1. pp. 97-102.

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Official URL: http://edoc.unibas.ch/dok/A5838887

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Abstract

We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 3'-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3'-UTR VNTR, respectively) of DAT1. In addition, a similar pattern of over-transmission of paternal risk haplotypes (constructed from the above alleles) was also observed. Some support is also derived from the two smaller samples although neither is independently significant. Although the mechanism driving the paternal over-transmission of the DAT risk alleles is not known, these finding provide further support for this phenomenon. (c) 2009 Wiley-Liss, Inc.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:1552-4841
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:55
Deposited On:08 Jun 2012 06:44

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