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Central venous pressure at emergency room presentation predicts cardiac rehospitalization in patients with decompensated heart failure

Uthoff, Heiko and Thalhammer, Christoph and Potocki, Mihael and Reichlin, Tobias and Noveanu, Markus and Aschwanden, Markus and Staub, Daniel and Arenja, Nisha and Socrates, Thenral and Twerenbold, Raphael and Mutschmann-Sanchez, Sarah and Heinisch, Corinna and Jaeger, Kurt A. and Mebazaa, Alexandre and Mueller, Christian. (2010) Central venous pressure at emergency room presentation predicts cardiac rehospitalization in patients with decompensated heart failure. European journal of heart failure, Vol. 12, H. 5. pp. 469-476.

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Official URL: http://edoc.unibas.ch/dok/A5843850

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Abstract

To investigate the relationship between central venous pressure (CVP) at presentation to the emergency room (ER) and the risk of cardiac rehospitalization and mortality in patients with decompensated heart failure (DHF).; Central venous pressure was determined non-invasively using high-resolution compression sonography at presentation in 100 patients with DHF. Cardiac hospitalizations and cardiac and all-cause mortality were assessed as a function of continuous CVP levels and predefined CVP categories (low >6 cm H(2)O, intermediate 6-23 cm H(2)O, and high <23 cm H(2)O). Endpoints were adjudicated blinded to CVP. At presentation, mean age was 78 +/- 11 years, 60% of patients were male, mean B-type natriuretic peptide level was 1904 +/- 1592 pg/mL, and mean CVP was 13.7 +/- 7.0 cm H(2)O (range 0-33). During follow-up (median 12 months), 25 cardiac rehospitalizations, 26 cardiac deaths, and 7 non-cardiac deaths occurred. Univariate and stepwise multivariate Cox regression analysis revealed an independent relationship between CVP and cardiac rehospitalization (HR 1.09, 95% CI 1.01-1.18, P = 0.034). Kaplan-Meier analyses confirmed a stepwise increase in cardiac rehospitalization for low-to-high CVP (log-rank test P = 0.015). No association between CVP and (cardiac) mortality was detectable.; Central venous pressure at ER presentation in patients with DHF is an independent predictor of cardiac rehospitalization but not of cardiac and all-cause mortality.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Angiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Angiologie
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Angiologie (Jäger)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Angiologie (Jäger)
UniBasel Contributors:Reichlin, Tobias and Jäger, Kurt A. and Staub, Daniel
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1388-9842
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:06
Deposited On:08 Jun 2012 06:43

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