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Use of copeptin in the detection of myocardial ischemia

Staub, Daniel and Morgenthaler, Nils G. and Buser, Claudia and Breidthardt, Tobias and Potocki, Mihael and Noveanu, Markus and Reichlin, Tobias and Bergmann, Andreas and Mueller, Christian. (2009) Use of copeptin in the detection of myocardial ischemia. Clinica Chimica Acta, Vol. 399, H. 1-2. pp. 69-73.

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Official URL: http://edoc.unibas.ch/dok/A5843868

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Abstract

The role of the arginine-vasopressin (AVP) system in the response to myocardial ischemia is unclear. Copeptin, the C-terminal part of the AVP prohormone is secreted stoichiometrically with AVP.; A total of 253 consecutive patients with suspected myocardial ischemia referred for rest/ergometry myocardial perfusion single-photon emission computed tomography (SPECT) were enrolled. We evaluated the response of copeptin during exercise and determined whether measurement of copeptin may be helpful in the detection of myocardial ischemia.; Myocardial ischemia on perfusion images was detected in 127 patients (50%). Median copeptin levels increased significantly with exercise in patients with ischemia as well as in patients without ischemia (from 3.8 [IQR 2.8-6.6] to 12.3 [IQR 5.2-39.6] pmol/l, P>0.001; and from 3.6 [IQR 2.6-5.7] to 10.8 [IQR 5.0-24.5] pmol/l, P>0.001). Median exercise-induced changes in copeptin (Deltacopeptin) were similar in both groups (7.7 versus 5.1 pmol/l, P=0.150). The area under the ROC curve for the ability of Deltacopeptin to detect myocardial ischemia was 0.552.; Copeptin levels increased threefold with exercise, irrespective of the presence or absence of myocardial ischemia. Therefore, myocardial ischemia does not seem to be a major trigger of the AVP system. Measurement of copeptin does not seem helpful in the detection of exercise-induced myocardial ischemia.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Angiologie (Jäger)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Angiologie (Jäger)
UniBasel Contributors:Müller, Christian and Staub, Daniel and Reichlin, Tobias
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0009-8981
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:02
Deposited On:08 Jun 2012 06:43

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