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Natriuretic peptides for the prediction of severely impaired peak VO2 in patients with lung disease

Maeder, Micha T. and Brutsche, Martin H. and Christ, Andreas and Reichlin, Tobias and Staub, Daniel and Noveanu, Markus and Breidthardt, Tobias and Potocki, Mihael and Mueller, Christian. (2009) Natriuretic peptides for the prediction of severely impaired peak VO2 in patients with lung disease. Respiratory medicine, Vol. 103, H. 9. pp. 1337-1345.

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Official URL: http://edoc.unibas.ch/dok/A5843862

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Abstract

B-type natriuretic peptide (BNP) is a predictor of death in patients with lung disease. We hypothesised that in patients with lung disease, BNP and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) could predict a peak VO(2)>15 ml/kg/min, which is the proposed cut-off indicating an increased risk of perioperative complications during lung resection surgery.; BNP and NT-proBNP were measured in 85 patients with a variety of pulmonary pathologies undergoing cardiopulmonary exercise testing and fulfilling criteria for appropriate effort.; BNP [69 (42-270) vs. 33 (15-65)pg/ml; p=0.001] and NT-proBNP [290 (129-1075) vs. 65 (21-129)pg/ml; p>0.001] were higher in patients with peak VO(2)>15 ml/kg/min (n=27) as compared to those with peak VO(2)< or =15 ml/kg/min (n=58). Apart from the forced expiratory volume within the first second (FEV(1)), body mass index (BMI), diabetes, and the alveolo-arterial oxygen pressure difference [D(A-a)O(2); only in the BNP model], BNP or NT-proBNP respectively were independent predictors of peak VO(2)>15 ml/kg/min. The areas under the receiver-operator-characteristics curve (AUC) for BNP and NT-proBNP to predict a peak VO(2)>15 ml/kg/min were 0.73 and 0.80 respectively. A five-item (BNP) or four-item (NT-proBNP) score including BMI, FEV(1), diabetes, D(A-a)O(2), and BNP/NT-proBNP had an AUC of 0.87 and 0.88 respectively for the prediction of peak VO(2)>15ml/kg/min.; In patients with lung disease, BNP or NT-proBNP is independently associated with low peak VO(2). A simple score based on spirometry, blood gases and BNP or NT-proBNP has a high accuracy for the prediction of a peak VO(2)>15 ml/kg/min.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Angiologie (Jäger)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Angiologie (Jäger)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Pneumologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Pneumologie
UniBasel Contributors:Brutsche, Martin and Müller, Christian and Staub, Daniel and Reichlin, Tobias
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Saunders
ISSN:0954-6111
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:40
Deposited On:08 Jun 2012 06:43

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