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Determinants of absolute and relative exercise-induced changes in B-type natriuretic peptides

Maeder, Micha T. and Staub, Daniel and Surnier, Yves and Reichlin, Tobias and Noveanu, Markus and Breidthardt, Tobias and Potocki, Mihael and Schaub, Nora and Conen, David and Mueller, Christian. (2011) Determinants of absolute and relative exercise-induced changes in B-type natriuretic peptides. International journal of cardiology, Vol. 147, H. 3. pp. 409-415.

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Official URL: http://edoc.unibas.ch/dok/A5843855

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Abstract

Exercise is associated with changes in circulating B-type natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP). However, the biological relevance of this phenomenon is poorly examined. We sought to assess determinants of absolute (?) and relative (?%) exercise-induced changes in BNP and NT-proBNP.; BNP (n = 418) and NT-proBNP (n = 478) at rest and peak exercise were measured in patients undergoing symptom-limited cycle ergometer tests. Multivariate logistic regression was performed to identify predictors of high ?BNP/?NT-proBNP and high ?BNP/?%NT-proBNP defined as their highest quartiles (Q4).; The median (interquartile range) ?BNP and ?NT-proBNP was 12 (0-28) pg/ml and 7 (2-21) pg/ml respectively, and ?%BNP and ?%NT-proBNP was 21 (0-46) % and 7 (3-12) % respectively. Higher BNP [odds ratio (OR) 3.92 per ln unit; p > 0.001] or NT-proBNP [OR 4.88 per ln unit; p>0.001] at rest was the strongest predictor of ?BNP in Q4 (? 28 pg/ml) or ?NT-proBNP in Q4 (? 21 pg/ml). In contrast, higher maximal work rate expressed as the percentage of the predicted value (OR 1.015 per %; p = 0.007) was the only independent predictor of ?%BNP in Q4 (? 46%), and lower resting heart rate (OR 0.97 per bpm; p = 0.001) and lower age (OR 0.95 per year; p = 0.001) were the only independent predictors of ?%NT-proBNP in Q4 (? 12%).; Higher ?BNP and ?NT-proBNP primarily reflected higher BNP and NT-proBNP plasma levels at rest. In contrast, higher ?%BNP and ?%NT-proBNP were associated with several prognostically favorable features, indicating that higher ?%BNP and ?%NT-proBNP may be markers of health rather than disease.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie
UniBasel Contributors:Reichlin, Tobias
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Excerpta medica
ISSN:0167-5273
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:55
Deposited On:08 Jun 2012 06:41

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