Cognitive impairment in patients with a schizoaffective disorder : a comparison with bipolar patients in euthymia

Studentkowski, G. and Scheele, D. and Calabrese, P. and Balkau, F. and Höffler, J. and Aubel, T. and Edel, M.-A. and Juckel, G. and Assion, Hans-Jörg. (2010) Cognitive impairment in patients with a schizoaffective disorder : a comparison with bipolar patients in euthymia. European journal of medical research, Vol. 15, H. 2. pp. 70-78.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5839936

Downloads: Statistics Overview


OBJECTIVES: Several studies have shown persistent neurocognitive impairment in patients with a bipolar affective disorder (BD) even in euthymia as well as in patients with a schizoaffective disorder (SAD). The aim of our study was to compare the neuropsychological performance between these two groups. Confounding variables were controlled to enhance our understanding of cognitive dysfunction in both BD and SAD. METHODS: Several domains of neurocognitive function, executive function, memory, attention, concentration and perceptuomotor function were examined in 28 euthymic SAD patients and 32 BD patients by using a neuropsychological test battery. The Hamilton Depression Rating Scale (HAMD), Montgomery-Asberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) were used to evaluate the patients' clinical status. Data analysis was performed by using a multivariate analysis of covariance (ANCOVA/MANCOVA). RESULTS: Euthymic SAD patients showed greater cognitive impairment than euthymic BD patients in the tested domains including declarative memory and attention. Putative significant group differences concerning cognitive flexibility vanished when controlled for demographic and clinical variables. Age and medication were robust predictors to cognitive performance of both SAD and BD patients. CONCLUSIONS: Our results point out the worse cognitive outcome of SAD compared to BD patients in remission. Remarkably, the variance is higher for some of the test results between the groups than within each group, this being discussed in light of the contradictive concept of SAD.
Faculties and Departments:03 Faculty of Medicine
07 Faculty of Psychology
UniBasel Contributors:Calabrese, Pasquale
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:I. Holzapfel
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:08 Jun 2012 06:53
Deposited On:08 Jun 2012 06:31

Repository Staff Only: item control page