Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease

Hock, Christoph and Konietzko, Uwe and Streffer, Johannes R. and Tracy, Jay and Signorell, Andri and Müller-Tillmanns, Britta and Lemke, Ulrike and Henke, Katharina and Moritz, Eva and Garcia, Esmeralda and Wollmer, M. Axel and Umbricht, Daniel and de Quervain, Dominique J. F. and Hofmann, Marc and Maddalena, Alessia and Papassotiropoulos, Andreas and Nitsch, Roger M.. (2003) Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron, Vol. 38, H. 4. pp. 547-554.

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Official URL: http://edoc.unibas.ch/dok/A5254842

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To test whether antibodies against beta-amyloid are effective in slowing progression of Alzheimer's disease, we assessed cognitive functions in 30 patients who received a prime and a booster immunization of aggregated Abeta(42) over a 1 year period in a placebo-controlled, randomized trial. Twenty patients generated antibodies against beta-amyloid, as determined by tissue amyloid plaque immunoreactivity assay. Patients who generated such antibodies showed significantly slower rates of decline of cognitive functions and activities of daily living, as indicated by the Mini Mental State Examination, the Disability Assessment for Dementia, and the Visual Paired Associates Test of delayed recall from the Wechsler Memory Scale, as compared to patients without such antibodies. These beneficial clinical effects were also present in two of three patients who had experienced transient episodes of immunization-related aseptic meningoencephalitis. Our results establish that antibodies against beta-amyloid plaques can slow cognitive decline in patients with Alzheimer's disease.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Molecular Neuroscience (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas and de Quervain, Dominique J.-F.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 Nov 2017 10:21
Deposited On:22 Mar 2012 13:16

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