Power consumption profile analysis and tensile strength measurements during moist agglomeration

Betz, G. and Burgin, P. J. and Leuenberger, H.. (2003) Power consumption profile analysis and tensile strength measurements during moist agglomeration. International journal of pharmaceutics, Vol. 252, H. 1/2. pp. 11-25.

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Official URL: http://edoc.unibas.ch/dok/A5249121

Abstract

This study was performed to elucidate the influences of process and formulation design on the granulation process using power consumption and tensile strength measurements. In order to record and analyze the power consumption profile in process a computer program was developed to be used for optimal end-point control in reproducible granule production. The program analyzes and calculates a characteristical point, the turning point of the S-shaped ascent of the profile. The tensile strength expresses the cohesiveness between the powder particles, which is dependent on saturation and capillary pressure. In order to investigate the influence of the amount of liquid present in the granular material on tensile strength a device was developed. The maxima of tensile strength occurred at 90 maxima of power consumption were determined at 100 measured tensile strength sigma (N/m(2)) equals to the volume specific cohesion (J/m(3)). The present work proved that the power consumption measurement is an alternative, simple and inexpensive method to determine the cohesion of powder particles. The turning point is introduced as a signature of the starting material and furthermore as a parameter for the cohesiveness of the starting material and therefore for optimal end-point detection at an early stage. (C) 2002 Elsevier Science B.V. All rights reserved.
Faculties and Departments: 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Industrial Pharmacy Lab (Betz) Betz, Gabriele Article, refereed Research Article Link to catalogue Elsevier 0378-5173 Publication type according to Uni Basel Research Database: Journal article isi: 000181050900002 22 Mar 2012 14:19 22 Mar 2012 13:16

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