Early embryonic expression of a 60-kD glycoprotein in the developing nervous system of the lobster

Garzino, V. and Reichert, H.. (1994) Early embryonic expression of a 60-kD glycoprotein in the developing nervous system of the lobster. Journal of comparative neurology, Vol. 346, H. 4. pp. 572-582.

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Official URL: http://edoc.unibas.ch/dok/A5250968

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To investigate the developmental processes that generate the crustacean nervous system, we used a monoclonal antibody that recognises an antigen that is expressed in the developing embryonic nervous system of the lobster, Homarus gammarus. Expression of this antigen commences early in embryogenesis, occurs in all parts of the embryonic central and peripheral nervous systems, and continues into adulthood. Initial expression in the central nervous system correlates with the onset of neuronal process outgrowth. Light microscopic analysis shows that the antigen is found surrounding the cell bodies and processes of all neurons. Biochemical analysis indicates that the antigen is a glycoprotein with an apparent molecular weight of 60 kD. Due to the early embryonic onset of its expression, this antigen is a useful cellular label for visualisation of pattern formation in the developing nervous system; this is documented in detail for the developing stomatogastric nervous system. The fact that the 60-kD antigen is expressed early in embryogenesis throughout the nervous system suggests that it might play an important role in the development of the lobster nervous system.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Molecular Zoology (Reichert)
UniBasel Contributors:Reichert, Heinrich
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:19
Deposited On:22 Mar 2012 13:16

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