# New approach for the synthesis of c-di-GMP and its analogues

Amiot, Nicolas and Heintz, Karine and Giese, Bernd. (2006) New approach for the synthesis of c-di-GMP and its analogues. Synthesis, 2006, H. 24. pp. 4230-4236.

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Official URL: http://edoc.unibas.ch/dok/A5249000

The synthesis of cyclic bis(3-5)diguanylic acid (c-di-GMP) by using a new flexible approach is reported. The flexibility of the method is exemplified by the synthesis of base-modified analogues that will find applications in the elucidation of c-di-GMP biological modes of action.