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Amphiphilic copolymer membranes promote NADH:Ubiquinone Oxidoreductase activity : towards an electron-transfer nanodevice

Graff, Alexandra and Fraysse-Ailhas, Caroline and Palivan, Cornelia G. and Grzelakowski, Mariusz and Friedrich, Thorsten and Vebert, Corinne and Gescheidt, Georg and Meier, Wolfgang. (2010) Amphiphilic copolymer membranes promote NADH:Ubiquinone Oxidoreductase activity : towards an electron-transfer nanodevice. Macromolecular Chemistry and Physics, 211 (2). pp. 229-238.

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Official URL: http://edoc.unibas.ch/dok/A5262593

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Abstract

Nanoscale devices for energy conversion require the transfer of electrons from one compartment to another. The enzyme complex I, which in vivo mediates electron transfer from NADH to ubiquinone, is an intriguing candidate for this role in nanodevices. However, complex I normally requires the presence of lipids to remain active, potentially limiting its application. Here we demonstrate for the first time that complex I can be actively reconstituted in the synthetic membrane of amphiphilic triblock copolymer vesicles. The functionality of the reconstituted protein was characterized by EPR and activity assays. Its activity is strongly influenced by the molar mass and the block length of the membrane-forming polymers, and increases with increasing membrane thickness.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Palivan, Cornelia G and Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1022-1352
e-ISSN:1521-3935
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:10 Apr 2017 07:37
Deposited On:22 Mar 2012 14:07

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