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Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery

Onaca, Ozana and Enea, Ramona and Hughes, David W. and Meier, Wolfgang. (2009) Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery. Macromolecular bioscience, Vol. 9, H. 2. pp. 129-139.

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Official URL: http://edoc.unibas.ch/dok/A5251055

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Abstract

Polymeric formulations (micelles, vesicles etc.) have emerged as versatile drug carriers due to their increased stability, site specificity, blood circulation resistance and thus overall potential therapeutic effects compared to liposomes. Furthermore, stimuli-responsive systems have been developed whose properties change after applying certain external triggers. Polymersomes are mainly composed of amphiphilic block copolymers that are held together in water due to strong physical interactions between the insoluble hydrophobic blocks, thus forming a bilayer morphology or, in the case of triblock copolymers, a bilayer-like morphology. Formation and destabilization of these assemblies is a consequence of external stimuli (temperature, pH, oxidation/reduction conditions etc.). This review focuses on recent developments concerning stimuli-responsive polymersomes made of amphiphilic block copolymers and their potential applications within the biomedical field.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-VCH
ISSN:1616-5195
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 06:56
Deposited On:22 Mar 2012 14:07

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