Mannose receptor mediated antigen uptake and presentation in human dendritic cells

Engering, A. J. and Cella, M. and Fluitsma, D. M. and Hoefsmit, E. C. and Lanzavecchia, A. and Pieters, J.. (1997) Mannose receptor mediated antigen uptake and presentation in human dendritic cells. Advances in experimental medicine and biology, 417. pp. 183-187.

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Official URL: http://edoc.unibas.ch/dok/A5259428

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In an immature state, dendritic cells (DC) can capture antigen via at least two mechanisms. First, DC use macropinocytosis for continuous uptake of large amounts of soluble antigens. Second, they express high levels of mannose receptor that can mediate internalization of glycosylated ligands. We found that dendritic cells can present mannosylated antigen 100-1000 fold more efficiently than non-mannosylated antigen. Immunocytochemistry as well as subcellular fractionation demonstrated that the mannose receptor and MHC class II molecules were located in distinct subcellular compartments. These results demonstrate that the mannose receptor endows DC with a high capacity to present glycosylated antigens at very low concentrations.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Plenum Press
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:27
Deposited On:22 Mar 2012 13:59

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