Anteroposterior regionalization of the brain : genetic and comparative aspects

Lichtneckert, Robert and Reichert, Heinrich. (2008) Anteroposterior regionalization of the brain : genetic and comparative aspects. Advances in experimental medicine and biology, 628. pp. 32-41.

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Official URL: http://edoc.unibas.ch/dok/A5250923

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Developmental genetic analyses of embryonic CNS development in Drosophila have uncovered the role of key, high-order developmental control genes in anteroposterior regionalization of the brain. The gene families that have been characterized include the otd/Otx and ems/Emx genes which are involved in specification of the anterior brain, the Hox genes which are involved in the differentiation of the posterior brain and the Pax genes which are involved in the development of the anterior/posterior brain boundary zone. Taken together with work on the genetic control of mammalian CNS development, these findings indicate that all three gene sets have evolutionarily conserved roles in brain development, revealing a surprising evolutionary conservation in the molecular mechanisms of brain regionalization.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Molecular Zoology (Reichert)
UniBasel Contributors:Reichert, Heinrich
Item Type:Article, refereed
Article Subtype:Research Article
Note:Also published in: Brain development in "Drosophila melanogaster". - New York : Springer, 2008. - S. 32-41 -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:27
Deposited On:22 Mar 2012 13:59

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