Haemodynamic effects of bradykinin in rats

Dienemann, H. and Wood, J. M. and Kraetz, J. and Stalder, R. and Hofbauer, K. G.. (1983) Haemodynamic effects of bradykinin in rats. Advances in experimental medicine and biology, vol. 156. pp. 651-660.

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Official URL: http://edoc.unibas.ch/dok/A5258675

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The intravenous infusion of bradykinin (20 micrograms/kg X min) induced an initial fall in blood pressure and total peripheral resistance in anaesthetized rats. These changes were accompanied with an increase in cardiac output and stroke volume. These effects were transient and after 20 min of infusion blood pressure and total peripheral resistance were much less decreased than initially. Cardiac output and stroke volume had completely normalized. Lower doses of bradykinin (1 microgram/kg X min), which did not affect blood pressure, induced a reduction in mesenteric and renal vascular resistance. After higher doses (4 or 20 micrograms/kg X min) mesenteric vascular resistance was further decreased but renal vascular resistance was unchanged or markedly increased. This renal vasoconstrictor response was almost absent in rats which were pretreated with indomethacin (4 mg/kg i.v.). Hence the increase in renal vascular resistance was most probably due to the stimulation of the synthesis of prostaglandins, which act as renal vasoconstrictors in the rat.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Hofbauer)
UniBasel Contributors:Hofbauer, Karl G.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Also published in: Kinins-III. - New York : Plenum Press, 1983. - S. 651-660 -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:33
Deposited On:22 Mar 2012 13:59

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