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Translating biomolecular recognition into nanomechanics

Fritz, J. and Baller, M. K. and Lang, H. P. and Rothuizen, H. and Vettiger, P. and Meyer, E. and Guntherodt, H. J. and Gerber, C. and Gimzewski, J. K.. (2000) Translating biomolecular recognition into nanomechanics. Science, Vol. 288, H. 5464. pp. 316-318.

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Official URL: http://edoc.unibas.ch/dok/A5262163

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Abstract

We report the specific transduction, via surface stress changes, of DNA hybridization and receptor-ligand binding into a direct nanomechanical response of microfabricated cantilevers. Cantilevers in an array were functionalized with a selection of biomolecules. The differential deflection of the cantilevers was found to provide a true molecular recognition signal despite Large nonspecific responses of individual cantilevers. Hybridization of complementary oligonucleotides shows that a single base mismatch between two 12-mer oligonucleotides is clearly detectable. Similar experiments on protein A-immunoglobulin interactions demonstrate the wide-ranging applicability of nanomechanical transduction to detect biomolecular recognition.
Faculties and Departments:05 Faculty of Science > Departement Physik > Physik > Nanomechanik (Meyer)
UniBasel Contributors:Meyer, Ernst
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
ISSN:0036-8075
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:22 Mar 2012 14:27
Deposited On:22 Mar 2012 13:55

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