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Analyzing refractive index changes and differential bending in microcantilever arrays

Huber, Francois and Lang, Hans Peter and Hegner, Martin and Despont, Michel and Drechsler, Ute and Gerber, Christoph. (2008) Analyzing refractive index changes and differential bending in microcantilever arrays. Review of Scientific Instruments, 79 (8). 086110.

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Official URL: http://edoc.unibas.ch/dok/A5251976

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Abstract

A new microcantilever array design is investigated comprising eight flexible microcantilevers introducing two solid bars, enabling to subtract contributions from differences in refractive index in an optical laser read out system. Changes in the refractive index do not contribute undesirably to bending signals at picomolar to micromolar DNA or protein concentrations. However, measurements of samples with high salt concentrations or serum are affected, requiring corrections for refractive index artifacts. Moreover, to obtain a deeper understanding Of molecular stress formation, the differential curvature of cantilevers is analyzed by positioning the laser spots along the surface of the levers during pH experiments.
Faculties and Departments:05 Faculty of Science > Departement Physik > Physik > Nanomechanik (Meyer)
UniBasel Contributors:Lang, Hans Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:AIP Publishing
ISSN:0034-6748
e-ISSN:1089-7623
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:16 Feb 2017 07:23
Deposited On:22 Mar 2012 13:55

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