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Leichte kognitive Beeinträchtigung mit Vorzeichen rascher Verschlechterung = Mild cognitive impairment with predictors of rapid decline

Förstl, H. and Bickel, H. and Frölich, L. and Gertz, H. J. and Kurz, A. and Marksteiner, J. and Monsch, A. U. and Pantel, J. and Schmidt, R. and Schönknecht, P.. (2008) Leichte kognitive Beeinträchtigung mit Vorzeichen rascher Verschlechterung = Mild cognitive impairment with predictors of rapid decline. Deutsche medizinische Wochenschrift, Jg. 133, H. 9. pp. 431-436.

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Official URL: http://edoc.unibas.ch/dok/A5250773

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Abstract

Half the patients with mild cognitive impairment (MCI) will develop dementia over a four-year period. The scientific literature was searched and analysed for predictors of rapid decline (MCI-plus) in patients with MCI. The most important predictors of fast cognitive deterioration were found to be: old age, previous rapid decline, severity and multiplicity of cognitive deficits, somatic co-morbidity, vascular and Alzheimer-type changes in the brain, Alzheimer-type cerebrospinal fluid findings and apolipoprotein E4 polymorphism. Many patients with MCI suffer from anxiety, depression or apathy and subtle, but subjectively significant, difficulties in the activities of daily living. It is concluded that MCI-plus offers a window for medical and psychological prophylaxis and rehabilitation.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Geriatrie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Geriatrie
07 Faculty of Psychology > Departement Psychologie
UniBasel Contributors:Monsch, Andreas U
Item Type:Article, refereed
Article Subtype:Book Review
Bibsysno:Link to catalogue
Publisher:Georg Thieme Verlag
ISSN:0012-0472
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:22 Mar 2012 14:26
Deposited On:22 Mar 2012 13:53

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