Items where Author is "Taylor, Dale"

2020

Mueller, Rudolf and Reddy, Virsinha and Nchinda, Aloysius T. and Mebrahtu, Fanuel and Taylor, Dale and Lawrence, Nina and Tanner, Lloyd and Barnabe, Marine and Eyermann, Charles J. and Zou, Bin and Kondreddi, Ravinder R. and Lakshminarayana, Suresh B. and Rottmann, Matthias and Street, Leslie J. and Chibale, Kelly. (2020) Lerisetron analogues with antimalarial properties: synthesis, structure-activity relationship studies, and biological assessment. ACS Omega, 5 (12). pp. 6967-6982.

2019

Kumar, Malkeet and Okombo, John and Mambwe, Dickson and Taylor, Dale and Lawrence, Nina and Reader, Janette and van der Watt, Mariëtte and Fontinha, Diana and Sanches-Vaz, Margarida and Bezuidenhout, Belinda C. and Lauterbach, Sonja B. and Liebenberg, Dale and Birkholtz, Lyn-Marie and Coetzer, Theresa L. and Prudêncio, Miguel and Egan, Timothy J. and Wittlin, Sergio and Chibale, Kelly. (2019) Multistage antiplasmodium activity of astemizole analogues and inhibition of hemozoin formation as a contributor to their mode of action. ACS infectious diseases, 5 (2). pp. 303-315.

2018

Le Manach, Claire and Paquet, Tanya and Wicht, Kathryn and Nchinda, Aloysius T. and Brunschwig, Christel and Njoroge, Mathew and Gibhard, Liezl and Taylor, Dale and Lawrence, Nina and Wittlin, Sergio and Eyermann, Charles J. and Basarab, Gregory S. and Duffy, James and Fish, Paul V. and Street, Leslie J. and Chibale, Kelly. (2018) Antimalarial lead-optimization studies on a 2,6-imidazopyridine series within a constrained chemical space to circumvent atypical dose-response curves against multidrug resistant parasite strains. Journal of medicinal chemistry, 61 (20). pp. 9371-9385.

Nchinda, Aloysius T. and Le Manach, Claire and Paquet, Tanya and Gonzàlez Cabrera, Diego and Wicht, Kathryn J. and Brunschwig, Christel and Njoroge, Mathew and Abay, Efrem and Taylor, Dale and Lawrence, Nina and Wittlin, Sergio and Jiménez-Díaz, María-Belén and Santos Martínez, María and Ferrer, Santiago and Angulo-Barturen, Iñigo and Lafuente-Monasterio, Maria Jose and Duffy, James and Burrows, Jeremy and Street, Leslie J. and Chibale, Kelly. (2018) Identification of fast-acting 2,6-disubstituted imidazopyridines that are efficacious in the In Vivo humanized Plasmodium falciparum nodscidil2rgamma (null) mouse model of malaria. Journal of medicinal chemistry, 61 (9). pp. 4213-4227.

Gibhard, Liezl and Njoroge, Mathew and Paquet, Tanya and Brunschwig, Christel and Taylor, Dale and Lawrence, Nina and Abay, Efrem and Wittlin, Sergio and Wiesner, Lubbe and Street, Leslie J. and Chibale, Kelly and Basarab, Gregory S.. (2018) Investigating sulfoxide to sulfone conversion as a prodrug strategy for a PI4K inhibitor in a humanized mouse model of malaria. Antimicrobial agents and chemotherapy, 62 (12). e00261-18.

Brunschwig, Christel and Lawrence, Nina and Taylor, Dale and Abay, Efrem and Njoroge, Mathew and Basarab, Gregory S. and Le Manach, Claire and Paquet, Tanya and Cabrera, Diego Gonzàlez and Nchinda, Aloysius T. and de Kock, Carmen and Wiesner, Lubbe and Denti, Paolo and Waterson, David and Blasco, Benjamin and Leroy, Didier and Witty, Michael J. and Donini, Cristina and Duffy, James and Wittlin, Sergio and White, Karen L. and Charman, Susan A. and Jiménez-Díaz, Maria Belén and Angulo-Barturen, Iñigo and Herreros, Esperanza and Gamo, Francisco Javier and Rochford, Rosemary and Mancama, Dalu and Coetzer, Theresa L. and van der Watt, Mariëtte E. and Reader, Janette and Birkholtz, Lyn-Marie and Marsh, Kennan C. and Solapure, Suresh M. and Burke, John E. and McPhail, Jacob A. and Vanaerschot, Manu and Fidock, David A. and Fish, Paul V. and Siegl, Peter and Smith, Dennis A. and Wirjanata, Grennady and Noviyanti, Rintis and Price, Ric N. and Marfurt, Jutta and Silue, Kigbafori D. and Street, Leslie J. and Chibale, Kelly. (2018) UCT943, a next generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria. Antimicrobial agents and chemotherapy, 62 (9). e00012-e00018.

2016

Le Manach, Claire and Nchinda, Aloysius T. and Paquet, Tanya and Gonzàlez Cabrera, Diego and Younis, Yassir and Han, Ze and Bashyam, Sridevi and Zabiulla, Mohammed and Taylor, Dale and Lawrence, Nina and White, Karen L. and Charman, Susan A. and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Botha, Mariëtte E. and Nondaba, Sindisiswe H. and Reader, Janette and Birkholtz, Lyn-Marie and Jiménez-Díaz, María Belén and Martínez, María Santos and Ferrer, Santiago and Angulo-Barturen, Iñigo and Meister, Stephan and Antonova-Koch, Yevgeniya and Winzeler, Elizabeth A. and Street, Leslie J. and Chibale, Kelly. (2016) Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life cycle. Journal of medicinal chemistry, 59 (21). pp. 9890-9905.

2015

Le Manach, Claire and Paquet, Tanya and Brunschwig, Christel and Njoroge, Mathew and Han, Ze and Gonzàlez Cabrera, Diego and Bashyam, Sridevi and Dhinakaran, Rajkumar and Taylor, Dale and Reader, Janette and Botha, Mariette and Churchyard, Alisje and Lauterbach, Sonja and Coetzer, Theresa L. and Birkholtz, Lyn-Marie and Meister, Stephan and Winzeler, Elizabeth A. and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Jiménez-Díaz, María-Belén and Santos Martínez, María and Ferrer, Santiago and Angulo-Barturen, Iñigo and Street, Leslie J. and Chibale, Kelly. (2015) A novel pyrazolopyridine with in vivo activity in Plasmodium berghei- and Plasmodium falciparum-infected mouse models from structure-activity relationship studies around the core of recently identified antimalarial imidazopyridazines. Journal of medicinal chemistry, 58 (21). pp. 8713-8722.

Gonzàlez Cabrera, Diego and Douelle, Frederic and Le Manach, Claire and Han, Ze and Paquet, Tanya and Taylor, Dale and Njoroge, Mathew and Lawrence, Nina and Wiesner, Lubbe and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Street, Leslie J. and Chibale, Kelly. (2015) Structure-activity relationship studies of orally active antimalarial 2,4-diamino-thienopyrimidines. Journal of medicinal chemistry, 58 (18). pp. 7572-7579.

2014

González Cabrera, Diego and Le Manach, Claire and Douelle, Frederic and Younis, Yassir and Feng, Tzu-Shean and Paquet, Tanya and Nchinda, Aloysius T. and Street, Leslie J. and Taylor, Dale and de Kock, Carmen and Wiesner, Lubbe and Duffy, Sandra and White, Karen L. and Zabiulla, K. Mohammed and Sambandan, Yuvaraj and Bashyam, Sridevi and Waterson, David and Witty, Michael J. and Charman, Susan A. and Avery, Vicky M. and Wittlin, Sergio and Chibale, Kelly. (2014) 2,4-diaminothienopyrimidines as orally active antimalarial agents. Journal of medicinal chemistry, 57 (3). pp. 1014-1022.

Le Manach, Claire and Gonzàlez Cabrera, Diego and Douelle, Frederic and Nchinda, Aloysius T. and Younis, Yassir and Taylor, Dale and Wiesner, Lubbe and White, Karen L. and Ryan, Eileen and March, Corinne and Duffy, Sandra and Avery, Vicky M. and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Charman, Susan A. and Street, Leslie J. and Chibale, Kelly. (2014) Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library : part 1. Journal of medicinal chemistry, 57 (6). pp. 2789-2798.

Le Manach, Claire and Paquet, Tanya and Gonzàlez Cabrera, Diego and Younis, Yassir and Taylor, Dale and Wiesner, Lubbe and Lawrence, Nina and Schwager, Sylva and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Street, Leslie J. and Chibale, Kelly. (2014) Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library : part 2. Journal of medicinal chemistry, 57 (21). pp. 8839-8848.