Items where Author is "Rottmann, M."

2023

Colina-Vegas, L. and da Cruz, B. Silva M. and de Souza Pereira, C. and Isis Barros, A. and Araújo Nobrega, J. and Navarro, M. and Rottmann, M. and D'Alessandro, S. and Basilico, N. and Azevedo Batista, A. and Moreira, D. R. M.. (2023) Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the plasmodium life cycle. Chemistry, 29 (55). e202301642.

2022

Lowe, M. A. and Cardenas, A. and Valentin, J. P. and Zhu, Z. and Abendroth, J. and Castro, J. L. and Class, R. and Delaunois, A. and Fleurance, R. and Gerets, H. and Gryshkova, V. and King, L. and Lorimer, D. D. and MacCoss, M. and Rowley, J. H. and Rosseels, M. L. and Royer, L. and Taylor, R. D. and Wong, M. and Zaccheo, O. and Chavan, V. P. and Ghule, G. A. and Tapkir, B. K. and Burrows, J. N. and Duffey, M. and Rottmann, M. and Wittlin, S. and Angulo-Barturen, I. and Jiménez-Díaz, M. B. and Striepen, J. and Fairhurst, K. J. and Yeo, T. and Fidock, D. A. and Cowman, A. F. and Favuzza, P. and Crespo-Fernandez, B. and Gamo, F. J. and Goldberg, D. E. and Soldati-Favre, D. and Laleu, B. and de Haro, T.. (2022) Discovery and characterization of potent, efficacious, orally available antimalarial plasmepsin X inhibitors and preclinical safety assessment of UCB7362. Journal of medicinal chemistry, 65 (20). pp. 14121-14143.

Wicha, S. G. and Walz, A. and Cherkaoui-Rbati, M. H. and Bundgaard, N. and Kuritz, K. and Gumpp, C. and Gobeau, N. and Möhrle, J. and Rottmann, M. and Demarta-Gatsi, C.. (2022) New in vitro interaction-parasite reduction ratio assay for early derisk in clinical development of antimalarial combinations. Antimicrob Agents Chemother, 66 (11). e0055622.

Radohery, G. F. R. and Walz, A. and Gumpp, C. and Cherkaoui-Rbati, M. H. and Gobeau, N. and Gower, J. and Davenport, M. P. and Rottmann, M. and McCarthy, J. S. and Möhrle, J. J. and Rebelo, M. and Demarta-Gatsi, C. and Khoury, D. S.. (2022) Parasite viability as a measure of in vivo drug activity in preclinical and early clinical antimalarial drug assessment. Antimicrob Agents Chemother, 66 (7). e0011422.

Hirsch, A. K. H. and Diamanti, E. and Hamed, M. M. and Lacour, A. and Bravo, P. and Illarionov, B. and Fischer, M. and Rottmann, M. and Witschel, M.. (2022) Targeting the IspD enzyme in the MEP pathway: identification of a novel fragment class. ChemMedChem, 17. e202100679.

Khandelwal, A. and Arez, F. and Alves, P. M. and Badolo, L. and Brito, C. and Fischli, C. and Fontinha, D. and Oeuvray, C. and Prudêncio, M. and Rottmann, M. and Wilkins, J. and Yalkinoglu, Ö. and Bagchus, W. M. and Spangenberg, T.. (2022) Translation of liver stage activity of M5717, a; Plasmodium; elongation factor 2 inhibitor: from bench to bedside. Malar J, 21. p. 151.

2021

Ropponen, H. K. and Diamanti, E. and Siemens, A. and Illarionov, B. and Haupenthal, J. and Fischer, M. and Rottmann, M. and Witschel, M. and Hirsch, A. K. H.. (2021) Assessment of the rules related to gaining activity against gram-negative bacteria. RSC Med Chem, 12 (4). pp. 593-601.

Ropponen, H. K. and Bader, C. D. and Diamanti, E. and Illarionov, B. and Rottmann, M. and Fischer, M. and Witschel, M. and Müller, R. and Hirsch, A. K. H.. (2021) Search for the active ingredients from a 2-aminothiazole DMSO stock solution with antimalarial activity. ChemMedChem, 16. pp. 2089-2093.

2013

Aureggi, V. and Ehmke, V. and Wieland, J. and Schweizer, W. B. and Bernet, B. and Bur, D. and Meyer, S. and Rottmann, M. and Freymond, C. and Brun, R. and Breit, B. and Diederich, F.. (2013) Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes. Chemistry : a European journal, Vol. 19, H. 1. pp. 155-164.

2012

Witschel, M. and Rottmann, M. and Kaiser, M. and Brun, R.. (2012) Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. PLoS neglected tropical diseases, Vol. 6, H. 10 , e1805.

Mäser, P. and Wittlin, S. and Rottmann, M. and Wenzler, T. and Kaiser, M. and Brun, R.. (2012) Antiparasitic agents : new drugs on the horizon. Current opinion in pharmacology, Vol. 12, H. 5. pp. 562-566.

Mugasa, J. and Qi, W. and Rusch, S. and Rottmann, M. and Beck, H. P.. (2012) Genetic diversity of expressed Plasmodium falciparum var genes from Tanzanian children with severe malaria. Malaria journal, Vol. 11 , 230.

Mombelli, P. and Witschel, M. C. and van Zijl, A. W. and Geist, J. G. and Rottmann, M. and Freymond, C. and Röhl, F. and Kaiser, M. and Illarionova, V. and Fischer, M. and Siepe, I. and Schweizer, W. B. and Brun, R. and Diederich, F.. (2012) Identification of 1,3-diiminoisoindoline carbohydrazides as potential antimalarial candidates. ChemMedChem, Vol. 7, H. 1. pp. 151-158.

Nagle, A. and Wu, T. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Liu, B. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Chuan, T. and Alper, P. B. and Fischli, C. and Brun, R. and Lakshminarayana, S. B. and Rottmann, M. and Diagana, T. T. and Winzeler, E. A. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2012) Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. Journal of medicinal chemistry, 55 (9). pp. 4244-4273.

Gemma, S. and Camodeca, C. and Sanna, Coccone and Joshi, B. P. and Bernetti, M. and Moretti, V. and Brogi, S. and Bonache, M. C. and Savini, L. and Taramelli, D. and Basilico, N. and Parapini, S. and Rottmann, M. and Brun, R. and Lamponi, S. and Caccia, S. and Guiso, G. and Summer, R. and Martin, R. and Saponara, S. and Gorelli, B. and Novellino, E. and Campiani, G. and Butini, S.. (2012) Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials : further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. Journal of medicinal chemistry, 55 (15). pp. 6948-6967.

van Pelt-Koops, J. C. and Pett, H. E. and Graumans, W. and Vegte-Bolmer, Mv and van Gemert, G. J. and Rottmann, M. and Yeung, B. K. and Diagana, T. T. and Sauerwein, R. W.. (2012) The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector. Antimicrobial agents and chemotherapy, Vol. 56, H. 7. pp. 3544-3548.

Ehmke, V. and Quinsaat, J. E. and Rivera-Fuentes, P. and Heindl, C. and Freymond, C. and Rottmann, M. and Brun, R. and Schirmeister, T. and Diederich, F.. (2012) Tuning and predicting biological affinity : aryl nitriles as cysteine protease inhibitors. Organic & biomolecular chemistry, Vol. 10, H. 30. pp. 5764-5768.

2011

Schiaffo, C. E. and Rottmann, M. and Wittlin, S. and Dussault, P. H.. (2011) 3-alkoxy-1,2-dioxolanes : synthesis and evaluation as potential antimalarial agents. ACS medicinal chemistry letters, Vol. 2, H. 4. pp. 316-319.

Chadwick, J. and Amewu, R. K. and Marti, F. and Bousejra-El Garah F., and Sharma, R. and Berry, N. G. and Stocks, P. A. and Burrell-Saward H., and Wittlin, S. and Rottmann, M. and Brun, R. and Taramelli, D. and Parapini, S. and Ward, S. A. and O'Neill P. M., . (2011) Antimalarial mannoxanes : hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 8. pp. 1357-1361.

Meister, S. and Plouffe, D. M. and Kuhen, K. L. and Bonamy, G. M. and Wu, T. and Barnes, S. W. and Bopp, S. E. and Borboa, R. and Bright, A. T. and Che, J. and Cohen, S. and Dharia, N. V. and Gagaring, K. and Gettayacamin, M. and Gordon, P. and Groessl, T. and Kato, N. and Lee, M. C. and McNamara, C. W. and Fidock, D. A. and Nagle, A. and Nam, T. G. and Richmond, W. and Roland, J. and Rottmann, M. and Zhou, B. and Froissard, P. and Glynne, R. J. and Mazier, D. and Sattabongkot, J. and Schultz, P. G. and Tuntland, T. and Walker, J. R. and Zhou, Y. and Chatterjee, A. and Diagana, T. T. and Winzeler, E. A.. (2011) Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science, Vol. 334, H. 6061. pp. 1372-1377.

Wu, T. and Nagle, A. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Goh, A. and Lakshminarayana, S. B. and Wu, J. and Ang, H. Q. and Zeng, P. and Kang, M. L. and Tan, W. and Tan, M. and Ye, N. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Fischli, C. and Brun, R. and Rottmann, M. and Dartois, V. and Keller, T. and Diagana, T. and Winzeler, E. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2011) Imidazolopiperazines: hit to lead optimization of new antimalarial agents. Journal of medicinal chemistry, 54 (14). pp. 5116-5130.

Tripathi, A. and Puddick, J. and Prinsep, M. R. and Rottmann, M. and Chan, K. P. and Chen, D. Y. and Tan, L. T.. (2011) Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula. Phytochemistry : an international journal of plant biochemistry, Vol. 72, H. 18. pp. 2369-2375.

Ehmke, V. and Heindl, C. and Rottmann, M. and Freymond, C. and Schweizer, W. B. and Brun, R. and Stich, A. and Schirmeister, T. and Diederich, F.. (2011) Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 273-278.

2010

Kalmbach, Y. and Rottmann, M. and Kombila, M. and Kremsner, P. G. and Beck, H. P. and Kun, J. F.. (2010) Differential var gene expression in children with malaria and antidromic effects on host gene expression. Journal of Infectious Diseases, Vol. 202, no. 2. pp. 313-317.

Tripathi, A. and Puddick, J. and Prinsep, M. R. and Rottmann, M. and Tan, L. T.. (2010) Lagunamides A and B : cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. Journal of natural products, Vol. 73, H. 11. pp. 1810-1814.

Nzila, A. and Rottmann, M. and Chitnumsub, P. and Kiara, S. M. and Kamchonwongpaisan, S. and Maneeruttanarungroj, C. and Taweechai, S. and Yeung, B. K. and Goh, A. and Lakshminarayana, S. B. and Zou, B. and Wong, J. and Ma, N. L. and Weaver, M. and Keller, T. H. and Dartois, V. and Wittlin, S. and Brun, R. and Yuthavong, Y. and Diagana, T. T.. (2010) Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrobial agents and chemotherapy : AAC, Vol. 54, H. 6. pp. 2603-2610.

Rottmann, M. and McNamara, C. and Yeung, B. K. and Lee, M. C. and Zou, B. and Russell, B. and Seitz, P. and Plouffe, D. M. and Dharia, N. V. and Tan, J. and Cohen, S. B. and Spencer, K. R. and Gonzalez-Paez G. E., and Lakshminarayana, S. B. and Goh, A. and Suwanarusk, R. and Jegla, T. and Schmitt, E. K. and Beck, H. P. and Brun, R. and Nosten, F. and Renia, L. and Dartois, V. and Keller, T. H. and Fidock, D. A. and Winzeler, E. A. and Diagana, T. T.. (2010) Spiroindolones, a potent compound class for the treatment of malaria. Science, Vol. 329, no. 5996. pp. 1175-1180.

Yeung, B. K. and Zou, B. and Rottmann, M. and Lakshminarayana, S. B. and Ang, S. H. and Leong, S. Y. and Tan, J. and Wong, J. and Keller-Maerki S., and Fischli, C. and Goh, A. and Schmitt, E. K. and Krastel, P. and Francotte, E. and Kuhen, K. and Plouffe, D. and Henson, K. and Wagner, T. and Winzeler, E. A. and Petersen, F. and Brun, R. and Dartois, V. and Diagana, T. T. and Keller, T. H.. (2010) Spirotetrahydro beta-carbolines (spiroindolones) : a new class of potent and orally efficacious compounds for the treatment of malaria. Journal of Medicinal Chemistry, 53 (14). pp. 5155-5164.

2009

Chavain, N. and Davioud-Charvet E., and Trivelli, X. and Mbeki, L. and Rottmann, M. and Brun, R. and Biot, C.. (2009) Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 17 (23). pp. 8048-8059.

Gemma, S. and Campiani, G. and Butini, S. and Joshi, B. P. and Kukreja, G. and Coccone, S. S. and Bernetti, M. and Persico, M. and Nacci, V. and Fiorini, I. and Novellino, E. and Taramelli, D. and Basilico, N. and Parapini, S. and Yardley, V. and Croft, S. and Keller-Maerki S., and Rottmann, M. and Brun, R. and Coletta, M. and Marini, S. and Guiso, G. and Caccia, S. and Fattorusso, C.. (2009) Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. Journal of Medicinal Chemistry, 52 (2). pp. 502-513.