Items where Author is "Rageot, Denise"

2020

Borsari, Chiara and Keles, Erhan and Rageot, Denise and Treyer, Andrea and Bohnacker, Thomas and Bissegger, Lukas and De Pascale, Martina and Melone, Anna and Sriramaratnam, Rohitha and Beaufils, Florent and Hamburger, Matthias and Hebeisen, Paul and Löscher, Wolfgang and Fabbro, Doriano and Hillmann, Petra and Wymann, Matthias P.. (2020) 4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a potent, orally available, and brain-penetrant mTOR inhibitor for the treatment of neurological disorders. Journal of Medicinal Chemistry, 63 (22). pp. 13595-13617.

2017

Beaufils, Florent and Cmiljanovic, Natasa and Cmiljanovic, Vladimir and Bohnacker, Thomas and Melone, Anna and Marone, Romina and Jackson, Eileen and Zhang, Xuxiao and Sele, Alexander and Borsari, Chiara and Mestan, Jurgen and Hebeisen, Paul and Hillmann, Petra and Giese, Bernd and Zvelebil, Marketa and Fabbro, Doriano and Williams, Roger L. and Rageot, Denise and Wymann, Matthias P.. (2017) 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. Journal of Medicinal Chemistry, 60 (17). pp. 7524-7538.

Bohnacker, Thomas and Prota, Andrea E. and Beaufils, Florent and Burke, John E. and Melone, Anna and Inglis, Alison J. and Rageot, Denise and Sele, Alexander M. and Cmiljanovic, Vladimir and Cmiljanovic, Natasa and Bargsten, Katja and Aher, Amol and Akhmanova, Anna and Fernando Diaz, J. and Fabbro, Doriano and Zvelebil, Marketa and Williams, Roger L. and Steinmetz, Michel O. and Wymann, Matthias P.. (2017) Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nature communications, 8. p. 14683.

2016

Sele, Alexander M. and Rageot, Denise and Bohnacker, Thomas and Beaufils, Florent and Prota, Andrea E. and Steinmetz, Michel O. and Wymann, Matthias P.. (2016) Novel 4-(pyrimidin-2-yl)morpholines targeting the colchicine-binding site of tubulin. Cancer Research, 76 (14). p. 1364.

Beaufils, Florent and Rageot, Denise and Melone, Anna and Sele, Alexander and Lang, Marc and Mestan, Juergen and Ettlin, Robert A. and Hillmann, Petra and Cmiljanovic, Vladimir and Walter, Carolin and Singer, Elisabeth and Nguyen, Hoa H. P. and Hebeisen, Paul and Fabbro, Dorian and Wymann, Matthias P.. (2016) Pharmacological characterization of the selective, orally bioavailable, potent mTORC1/2 inhibitor PQR620. Cancer Research, 76 (14). 393A.

Beaufils, Florent and Rageot, Denise and Melone, Anna and Lang, Marc and Mestan, Jürgen and Cmiljanovic, Vladimir and Hillmann, Petra and Hebeisen, Paul and Fabbro, Doriano and Wymann, Matthias P.. (2016) Structure-activity relationship studies, synthesis, and biological evaluation of PQR620, a highly potent and selective mTORC1/2 inhibitor. Cancer Research, 76 (14). p. 1336.

2015

Bohnacker, Thomas and Beaufils, Florent and Prota, Andrea E. and Burke, John E. and Melone, Anna and Inglis, Alison J. and Fusco, Ludovico and Cmiljanovic, Vladimir and Cmiljanovic, Natasa and Rageot, Denise and Bargsten, Katja and Saez-Calvo, Gonzalo and Pertz, Olivier and Aher, Amol B. and Akhmanova, Anna and Diaz, Fernando J. and Fabbro, Doriano and Zvelebil, Marketa and Williams, Roger L. and Steinmetz, Michel O. and Wymann, Matthias P.. (2015) BKM120-mediated G2 arrest: Structural and functional segregation of off-target action and PI3K inhibition. Cancer Research, 75 (15). p. 671.

2012

Rageot, Denise and Pfaltz, Andreas. (2012) Chiral Proline-Based P,O and P,N Ligands for Iridium-Catalyzed Asymmetric Hydrogenation. Helvetica Chimica Acta, 95 (11). pp. 2176-2193.

Rageot, Denise. Chiral proline-based ligands for iridium-catalyzed asymmetric hydrogenation. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Ganic, Adnan and Rageot, Denise and Tröndlin, Lars and Pfaltz, Andreas. (2012) Recent Advances in Iridium-Catalyzed Asymmetric Hydrogenation : New Catalysts, Substrates and Applications in Total Synthesis. Chimia, 66 (4). pp. 187-191.

2011

Rageot, Denise and Woodmansee, David H. and Pugin, Benoît and Pfaltz, Andreas. (2011) Proline Based P,O Iridium Complexes as Highly Selective Catalysts in the Asymmetric Hydrogenation of Trisubstituted Alkenes. Angewandte Chemie International Edition, 50 (41). pp. 9598-9601.