Items where Author is "Prudêncio, Miguel"

2019

Arez, Francisca and Rebelo, Sofia P. and Fontinha, Diana and Simão, Daniel and Martins, Tatiana R. and Machado, Marta and Fischli, Christoph and Oeuvray, Claude and Badolo, Lassina and Carrondo, Manuel J. T. and Rottmann, Matthias and Spangenberg, Thomas and Brito, Catarina and Greco, Beatrice and Prudêncio, Miguel and Alves, Paula M.. (2019) Flexible 3D cell-based platforms for the discovery and profiling of novel drugs targeting plasmodium hepatic infection. ACS infectious diseases, 5 (11). pp. 1831-1842.

Kumar, Malkeet and Okombo, John and Mambwe, Dickson and Taylor, Dale and Lawrence, Nina and Reader, Janette and van der Watt, Mariëtte and Fontinha, Diana and Sanches-Vaz, Margarida and Bezuidenhout, Belinda C. and Lauterbach, Sonja B. and Liebenberg, Dale and Birkholtz, Lyn-Marie and Coetzer, Theresa L. and Prudêncio, Miguel and Egan, Timothy J. and Wittlin, Sergio and Chibale, Kelly. (2019) Multistage antiplasmodium activity of astemizole analogues and inhibition of hemozoin formation as a contributor to their mode of action. ACS infectious diseases, 5 (2). pp. 303-315.

Mayoka, Godfrey and Njoroge, Mathew and Okombo, John and Gibhard, Liezl and Sanches-Vaz, Margarida and Fontinha, Diana and Birkholtz, Lyn-Marie and Reader, Janette and van der Watt, Mariëtte and Coetzer, Theresa L. and Lauterbach, Sonja and Churchyard, Alisje and Bezuidenhout, Belinda and Egan, Timothy J. and Yeates, Clive Leonard and Wittlin, Sergio and Prudêncio, Miguel and Chibale, Kelly. (2019) Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria. Journal of medicinal chemistry, 62 (2). pp. 1022-1035.

2017

Singh, Kawaljit and Okombo, John and Brunschwig, Christel and Ndubi, Ferdinand and Barnard, Linley and Wilkinson, Chad and Njogu, Peter M. and Njoroge, Mathew and Laing, Lizahn and Machado, Marta and Prudêncio, Miguel and Reader, Janette and Botha, Mariette and Nondaba, Sindisiwe and Birkholtz, Lyn-Marie and Lauterbach, Sonja and Churchyard, Alisje and Coetzer, Theresa L. and Burrows, Jeremy N. and Yeates, Clive and Denti, Paolo and Wiesner, Lubbe and Egan, Timothy J. and Wittlin, Sergio and Chibale, Kelly. (2017) Antimalarial pyrido[1,2-a]benzimidazoles : lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics, and in vivo oral efficacy in a mouse model. Journal of medicinal chemistry, 60 (4). pp. 1432-1448.