Items where Author is "Knapp, Stefan"

2016

Picaud, Sarah and Leonards, Katharina and Lambert, Jean-Philippe and Dovey, Oliver and Wells, Christopher and Fedorov, Oleg and Monteiro, Octovia and Fujisawa, Takao and Wang, Chen-Yi and Lingard, Hannah and Tallant, Cynthia and Nikbin, Nikzad and Guetzoyan, Lucie and Ingham, Richard and Ley, Steven V. and Brennan, Paul and Muller, Susanne and Samsonova, Anastasia and Gingras, Anne-Claude and Schwaller, Juerg and Vassiliou, George and Knapp, Stefan and Filippakopoulos, Panagis. (2016) Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. Science advances, 2 (10). e1600760.

2015

Picaud, Sarah and Fedorov, Oleg and Thanasopoulou, Angeliki and Leonards, Katharina and Jones, Katherine and Meier, Julia and Olzscha, Heidi and Monteiro, Octovia and Martin, Sarah and Philpott, Martin and Tumber, Anthony and Filippakopoulos, Panagis and Yapp, Clarence and Wells, Christopher and Che, Ka Hing and Bannister, Andrew and Robson, Samuel and Kumar, Umesh and Parr, Nigel and Lee, Kevin and Lugo, Dave and Jeffrey, Philip and Taylor, Simon and Vecellio, Matteo L. and Bountra, Chas and Brennan, Paul E. and O'Mahony, Alison and Velichko, Sharlene and Müller, Susanne and Hay, Duncan and Daniels, Danette L. and Urh, Marjeta and La Thangue, Nicholas B. and Kouzarides, Tony and Prinjha, Rab and Schwaller, Jürg and Knapp, Stefan. (2015) Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy. Cancer research, 75 (23). pp. 5106-5119.

2013

Picaud, Sarah and Da Costa, David and Thanasopoulou, Angeliki and Filippakopoulos, Panagis and Fish, Paul V. and Philpott, Martin and Fedorov, Oleg and Brennan, Paul and Bunnage, Mark E. and Owen, Dafydd R. and Bradner, James E. and Taniere, Philippe and O'Sullivan, Brendan and Müller, Susanne and Schwaller, Juerg and Stankovic, Tatjana and Knapp, Stefan. (2013) PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains. Cancer Research, 73 (11). pp. 3336-3346.

2012

Huber, Kilian and Brault, Laurent and Fedorov, Oleg and Gasser, Christelle and Filippakopoulos, Panagis and Bullock, Alex N. and Fabbro, Doriano and Trappe, Jörg and Schwaller, Jürg and Knapp, Stefan and Bracher, Franz. (2012) 7,8-dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. Journal of Medicinal Chemistry, 55 (1). pp. 403-413.

Brault, Laurent and Menter, Thomas and Obermann, Ellen C. and Knapp, Stefan and Thommen, Sarah and Schwaller, Jürg and Tzankov, Alexandar. (2012) PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma. British journal of cancer, 107 (3). pp. 491-500.

Adams, Cassandra J. and Pike, Ashley C. W. and Maniam, Sandra and Sharpe, Timothy D. and Coutts, Amanda S. and Knapp, Stefan and La Thangue, Nicholas B. and Bullock, Alex N.. (2012) The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure. Proceedings of the National Academy of Sciences, 109 (10). pp. 3778-3783.

2011

Miduturu, Chandrasekhar V. and Deng, Xianming and Kwiatkowski, Nicholas and Yang, Wannian and Brault, Laurent and Filippakopoulos, Panagis and Chung, Eunah and Yang, Qingkai and Schwaller, Juerg and Knapp, Stefan and King, Randall W. and Lee, Jiing-Dwan and Herrgard, Sanna and Zarrinkar, Patrick and Gray, Nathanael S.. (2011) High-throughput kinase profiling : a more efficient approach toward the discovery of new kinase inhibitors. Chemistry & biology, Vol. 18, H. 7. pp. 868-879.

2010

Brault, Laurent and Gasser, Christelle and Bracher, Franz and Huber, Kilian and Knapp, Stefan and Schwaller, Jürg. (2010) PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica, Vol. 95, H. 6. pp. 1004-1015.

2009

Grundler, Rebekka and Brault, Laurent and Gasser, Christelle and Bullock, Alex N. and Dechow, Tobias and Woetzel, Sabine and Pogacic, Vanda and Villa, Antonello and Ehret, Sabine and Berridge, Georgina and Spoo, Anke and Dierks, Christine and Biondi, Andrea and Knapp, Stefan and Duyster, Justus and Schwaller, Juerg. (2009) Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. Journal of Experimental Medicine, 206 (9). pp. 1957-1970.