Items where Author is "Heim, Markus H."

2022

Ng, Charlotte K. Y. and Dazert, Eva and Boldanova, Tuyana and Coto-Llerena, Mairene and Nuciforo, Sandro and Ercan, Caner and Suslov, Aleksei and Meier, Marie-Anne and Bock, Thomas and Schmidt, Alexander and Ketterer, Sylvia and Wang, Xueya and Wieland, Stefan and Matter, Matthias S. and Colombi, Marco and Piscuoglio, Salvatore and Terracciano, Luigi M. and Hall, Michael N. and Heim, Markus H.. (2022) Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages. Nature Communications, 13. p. 2436.

Suter, Polina and Dazert, Eva and Kuipers, Jack and Ng, Charlotte K. Y. and Boldanova, Tuyana and Hall, Michael N. and Heim, Markus H. and Beerenwinkel, Niko. (2022) Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture model. PLoS computational biology, 18 (9). e1009767.

Park, Sujin and Mossmann, Dirk and Chen, Qian and Wang, Xueya and Dazert, Eva and Colombi, Marco and Schmidt, Alexander and Ryback, Brendan and Ng, Charlotte K. Y. and Terracciano, Luigi M. and Heim, Markus H. and Hall, Michael N.. (2022) Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. Molecular Cell, 82 (22). pp. 4246-4261.e11.

7 March 2021

Ng, Charlotte K. Y. and Dazert, Eva and Boldanova, Tujana and Coto-Llerena, Mairene and Nuciforo, Sandro and Ercan, Caner and Suslov, Aleksei and Meier, Marie-Anne and Bock, Thomas and Schmidt, Alexander and Ketterer, Sylvia and Wang, Xueya and Wieland , Stefan and Matter, Matthias S. and Colombi, Marco and Piscuoglio, Salvatore and Terracciano, Luigi and Hall, Michael N. and Heim, Markus H.. (2021) Proteogenomic characterization of hepatocellular carcinoma.

2021

Gao, Ruize and Buechel, David and Kalathur, Ravi K. R. and Morini, Marco F. and Coto-Llerena, Mairene and Ercan, Caner and Piscuoglio, Salvatore and Chen, Qian and Blumer, Tanja and Wang, Xueya and Dazert, Eva and Heim, Markus H. and Hall, Michael N. and Tang, Fengyuan and Christofori, Gerhard. (2021) USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis. Oncogenesis, 10 (7). p. 52.

2019

Tang, Fengyuan and Gao, Ruize and Jeevan-Raj, Beena and Wyss, Christof B. and Kalathur, Ravi K. R. and Piscuoglio, Salvatore and Ng, Charlotte K. Y. and Hindupur, Sravanth K. and Nuciforo, Sandro and Dazert, Eva and Bock, Thomas and Song, Shuang and Buechel, David and Morini, Marco F. and Hergovich, Alexander and Matthias, Patrick and Lim, Dae-Sik and Terracciano, Luigi M. and Heim, Markus H. and Hall, Michael N. and Christofori, Gerhard. (2019) LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function. Nature Communications, 10 (1). p. 5755.

2018

Paradiso, Viola and Garofoli, Andrea and Tosti, Nadia and Lanzafame, Manuela and Perrina, Valeria and Quagliata, Luca and Matter, Matthias S. and Wieland, Stefan and Heim, Markus H. and Piscuoglio, Salvatore and Ng, Charlotte K. Y. and Terracciano, Luigi M.. (2018) Diagnostic Targeted Sequencing Panel for Hepatocellular Carcinoma Genomic Screening. The Journal of molecular diagnostics : JMD, 20 (6). pp. 836-848.

Nuciforo, Sandro and Fofana, Isabel and Matter, Matthias S. and Blumer, Tanja and Calabrese, Diego and Boldanova, Tujana and Piscuoglio, Salvatore and Wieland, Stefan and Ringnalda, Femke and Schwank, Gerald and Terracciano, Luigi M. and Ng, Charlotte K. Y. and Heim, Markus H.. (2018) Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies. Cell reports, 24 (5). pp. 1363-1376.

Hindupur, Sravanth K. and Colombi, Marco and Fuhs, Stephen R. and Matter, Matthias S. and Guri, Yakir and Adam, Kevin and Cornu, Marion and Piscuoglio, Salvatore and Ng, Charlotte K. Y. and Betz, Charles and Liko, Dritan and Quagliata, Luca and Moes, Suzette and Jenoe, Paul and Terracciano, Luigi M. and Heim, Markus H. and Hunter, Tony and Hall, Michael N.. (2018) The protein histidine phosphatase LHPP is a tumour suppressor. Nature, 555. pp. 678-682.

2017

Gauthiez, Emeline and Habfast-Robertson, Ines and Rüeger, Sina and Kutalik, Zoltan and Aubert, Vincent and Berg, Thomas and Cerny, Andreas and Gorgievski, Meri and George, Jacob and Heim, Markus H. and Malinverni, Raffaele and Moradpour, Darius and Müllhaupt, Beat and Negro, Francesco and Semela, David and Semmo, Nasser and Villard, Jean and Bibert, Stéphanie and Bochud, Pierre-Yves and Swiss Hepatitis C. Cohort Study, . (2017) A systematic review and meta‐analysis of HCV clearance. Liver International, 37 (10). pp. 1431-1445.

Campana, B. and Calabrese, Diego and Matter, M. S. and Terracciano, L. M. and Wieland, Stefan F. and Heim, Markus H.. (2017) In vivo analysis at the cellular level reveals similar steatosis induction in both hepatitis C virus genotype 1 and 3 infections. Journal of Viral Hepatitis, 25 (3). pp. 262-271.

Rey, Silvia and Quintavalle, Cristina and Burmeister, Katharina and Calabrese, Diego and Schlageter, Manuel and Quagliata, Luca and Cathomas, Gieri and Diebold, Joachim and Molinolo, Alfredo and Heim, Markus H. and Terracciano, Luigi M. and Matter, Matthias S.. (2017) Liver damage and senescence increases in patients developing hepatocellular carcinoma. Journal of gastroenterology and hepatology, 32 (8). pp. 1480-1486.

Blumer, Tanja and Coto-Llerena, Mairene and Duong, Francois H. T. and Heim, Markus H.. (2017) SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)–induced gene expression in vivo. Journal of Biological Chemistry, 292 (43). pp. 17928-17938.

Boldanova, Tujana and Suslov, Aleksei and Heim, Markus H. and Necsulea, Anamaria. (2017) Transcriptional response to hepatitis C virus infection and interferon-alpha treatment in the human liver. EMBO Molecular Medicine, 9 (6). pp. 816-834.

Guri, Yakir and Colombi, Marco and Dazert, Eva and Hindupur, Sravanth K. and Roszik, Jason and Moes, Suzette and Jenoe, Paul and Heim, Markus H. and Riezman, Isabelle and Riezman, Howard and Hall, Michael N.. (2017) mTORC2 Promotes Tumorigenesis via Lipid Synthesis. Cancer Cell, 32 (6). pp. 807-832.

Van Renne, Nicolaas and Roca Suarez, Armando Andres and Duong, Francois H. T. and Gondeau, Claire and Calabrese, Diego and Fontaine, Nelly and Ababsa, Amina and Bandiera, Simonetta and Croonenborghs, Tom and Pochet, Nathalie and De Blasi, Vito and Pessaux, Patrick and Piardi, Tullio and Sommacale, Daniele and Ono, Atsushi and Chayama, Kazuaki and Fujita, Masashi and Nakagawa, Hidewaki and Hoshida, Yujin and Zeisel, Mirjam B. and Heim, Markus H. and Baumert, Thomas F. and Lupberger, Joachim. (2017) miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis. Gut, 67 (5). pp. 953-962.

2 February 2016

Dazert, Eva and Colombi, Marco and Boldanova, Tujana and Moes, Suzette and Adametz, David and Quagliata, Luca and Roth, Volker and Terracciano, Luigi and Heim, Markus H. and Jenoe, Paul and Hall, Michael N.. (2016) Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient. Proceedings of the National Academy of Sciences of the United States of America, 113 (5). pp. 1381-1386.

2016

Ulveling, Damien and Le Clerc, Sigrid and Cobat, Aurélie and Labib, Taoufik and Noirel, Josselin and Laville, Vincent and Coulonges, Cédric and Carpentier, Wassila and Nalpas, Bertrand and Heim, Markus H. and Poynard, Thierry and Cerny, Andreas and Pol, Stanislas and Bochud, Pierre-Yves and Dabis, François and Theodorou, Ioannis and Lévy, Yves and Salmon, Dominique and Abel, Laurent and Dominguez, Stéphanie and Zagury, Jean-François and Swiss Hepatitis C. Cohort Study Group, . (2016) A new 3p25 locus is associated with liver fibrosis progression in human immunodeficiency virus/hepatitis C virus-coinfected patients. Hepatology, 64 (5). pp. 1462-1472.

Planas-Paz, Lara and Orsini, Vanessa and Boulter, Luke and Calabrese, Diego and Pikiolek, Monika and Nigsch, Florian and Xie, Yang and Roma, Guglielmo and Donovan, Adriana and Marti, Patricia and Beckmann, Nicolau and Dill, Michael T. and Carbone, Walter and Bergling, Sebastian and Isken, Andrea and Mueller, Matthias and Kinzel, Bernd and Yang, Yi and Mao, Xiaohong and Nicholson, Thomas B. and Zamponi, Raffaella and Capodieci, Paola and Valdez, Reginald and Rivera, Daniel and Loew, Andreas and Ukomadu, Chinweike and Terracciano, Luigi M. and Bouwmeester, Tewis and Cong, Feng and Heim, Markus H. and Forbes, Stuart J. and Ruffner, Heinz and Tchorz, Jan S.. (2016) Corrigendum: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nature Cell Biology , 18 (11). p. 1260.

Makowska, Zuzanna and Boldanova, Tujana and Adametz, David and Quagliata, Luca and Vogt, Julia E. and Dill, Michael T. and Matter, Mathias S. and Roth, Volker and Terracciano, Luigi and Heim, Markus H.. (2016) Gene expression analysis of biopsy samples reveals critical limitations of transcriptome-based molecular classifications of hepatocellular carcinoma. The Journal of Pathology : Clinical Research , 2 (2). pp. 80-92.

Andreozzi, Mariacarla and Quintavalle, Cristina and Benz, David and Quagliata, Luca and Matter, Matthias and Calabrese, Diego and Tosti, Nadia and Ruiz, Christian and Trapani, Francesca and Tornillo, Luigi and Fusco, Alfredo and Heim, Markus H. and Ng, Charlotte K. Y. and Pallante, Pierlorenzo and Terracciano, Luigi M. and Piscuoglio, Salvatore. (2016) HMGA1 Expression in Human Hepatocellular Carcinoma Correlates with Poor Prognosis and Promotes Tumor Growth and Migration in in vitro Models. Neoplasia, 18 (12). pp. 724-731.

Themanns, Madeleine and Mueller, Kristina M. and Kessler, Sonja M. and Golob-Schwarzl, Nicole and Mohr, Thomas and Kaltenecker, Doris and Bourgeais, Jerome and Paier-Pourani, Jamile and Friedbichler, Katrin and Schneller, Doris and Schlederer, Michaela and Zebedin-Brandl, Eva and Terracciano, Luigi M. and Han, Xiaonan and Kenner, Lukas and Wagner, Kay-Uwe and Mikulits, Wolfgang and Kozlov, Andrey V. and Heim, Markus H. and Gouilleux, Fabrice and Haybaeck, Johannes and Moriggl, Richard. (2016) Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice. Scientific Reports, 6. p. 34719.

Bernsmeier, Christine and Dill, Michael T. and Provenzano, Angela and Makowska, Zuzanna and Krol, Ilona and Muscogiuri, Giovanna and Semela, David and Tornillo, Luigi and Marra, Fabio and Heim, Markus H. and Duong, François H. T.. (2016) Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation. Laboratory Investigation, 96 (9). pp. 972-980.

Bandiera, Simonetta and Pernot, Sophie and El Saghire, Hussein and Durand, Sarah C. and Thumann, Christine and Crouchet, Emilie and Ye, Tao and Fofana, Isabel and Oudot, Marine A. and Barths, Jochen and Schuster, Catherine and Pessaux, Patrick and Heim, Markus H. and Baumert, Thomas F. and Zeisel, Mirjam B.. (2016) Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis. Journal of virology, 90 (14). pp. 6387-6400.

Planas-Paz, Lara and Orsini, Vanessa and Boulter, Luke and Calabrese, Diego and Pikiolek, Monika and Nigsch, Florian and Xie, Yang and Roma, Guglielmo and Donovan, Adriana and Marti, Patricia and Beckmann, Nicolau and Dill, Michael T. and Carbone, Walter and Bergling, Sebastian and Isken, Andrea and Mueller, Matthias and Kinzel, Bernd and Yang, Yi and Mao, Xiaohong and Nicholson, Thomas B. and Zamponi, Raffaella and Capodieci, Paola and Valdez, Reginald and Rivera, Daniel and Loew, Andreas and Ukomadu, Chinweike and Terracciano, Luigi M. and Bouwmeester, Tewis and Cong, Feng and Heim, Markus H. and Forbes, Stuart J. and Ruffner, Heinz and Tchorz, Jan S.. (2016) The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nature Cell Biology , 18 (5). pp. 467-479.

2015

Jansen, Louis and de Niet, Annikki and Makowska, Zuzanna and Dill, Michael T. and van Dort, Karel A. and Terpstra, Valeska and Bart Takkenberg, R. and Janssen, Harry L. A. and Heim, Markus H. and Kootstra, Neeltje A. and Reesink, Hendrik W.. (2015) An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B. Liver International, 35 (7). pp. 1824-1832.

Mailly, Laurent and Xiao, Fei and Lupberger, Joachim and Wilson, Garrick K. and Aubert, Philippe and Duong, François H. T. and Calabrese, Diego and Leboeuf, Céline and Fofana, Isabel and Thumann, Christine and Bandiera, Simonetta and Lütgehetmann, Marc and Volz, Tassilo and Davis, Christopher and Harris, Helen J. and Mee, Christopher J. and Girardi, Erika and Chane-Woon-Ming, Béatrice and Ericsson, Maria and Fletcher, Nicola and Bartenschlager, Ralf and Pessaux, Patrick and Vercauteren, Koen and Meuleman, Philip and Villa, Pascal and Kaderali, Lars and Pfeffer, Sébastien and Heim, Markus H. and Neunlist, Michel and Zeisel, Mirjam B. and Dandri, Maura and McKeating, Jane A. and Robinet, Eric and Baumert, Thomas F.. (2015) Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody. Nature Biotechnology, 33 (5). pp. 549-554.

Pfaender, Stephanie and Cavalleri, Jessika M. V. and Walter, Stephanie and Doerrbecker, Juliane and Campana, Benedetta and Brown, Richard J. P. and Burbelo, Peter D. and Postel, Alexander and Hahn, Kerstin and Anggakusuma, and Riebesehl, Nina and Baumgärtner, Wolfgang and Becher, Paul and Heim, Markus H. and Pietschmann, Thomas and Feige, Karsten and Steinmann, Eike. (2015) Clinical course of infection and viral tissue tropism of hepatitis C virus-like nonprimate hepaciviruses in horses. Hepatology, 61 (2). pp. 447-459.

Terczyńska-Dyla, Ewa and Bibert, Stephanie and Duong, Francois H. T. and Krol, Ilona and Jørgensen, Sanne and Collinet, Emilie and Kutalik, Zoltán and Aubert, Vincent and Cerny, Andreas and Kaiser, Laurent and Malinverni, Raffaele and Mangia, Alessandra and Moradpour, Darius and Müllhaupt, Beat and Negro, Francesco and Santoro, Rosanna and Semela, David and Semmo, Nasser and Swiss Hepatitis C. Cohort Study Group, and Heim, Markus H. and Bochud, Pierre-Yves and Hartmann, Rune. (2015) Corrigendum: Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes. Nature Communications, 6. p. 7280.

Rothweiler, Sonja and Dill, Michael T. and Terracciano, Luigi and Makowska, Zuzanna and Quagliata, Luca and Hlushchuk, Ruslan and Djonov, Valentin and Heim, Markus H. and Semela, David. (2015) Generation of a murine hepatic angiosarcoma cell line and reproducible mouse tumor model. Laboratory Investigation, 95 (3). pp. 351-362.

Anggakusuma, Institute of Experimental Virology and Twincore Centre for Experimental, and Clinical Infection Research, Hannover and Germany., and Romero-Brey, Inés and Berger, Carola and Colpitts, Che C. and Boldanova, Tujana and Engelmann, Michael and Todt, Daniel and Perin, Paula Monteiro and Behrendt, Patrick and Vondran, Florian W. R. and Xu, Shuting and Goffinet, Christine and Schang, Luis M. and Heim, Markus H. and Bartenschlager, Ralf and Pietschmann, Thomas and Steinmann, Eike. (2015) Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation. Hepatology, 62 (3). pp. 702-714.

Bernsmeier, Christine and Weisskopf, Diego M. and Pflueger, Marlon O. and Mosimann, Jan and Campana, Benedetta and Terracciano, Luigi and Beglinger, Christoph and Heim, Markus H. and Cajochen, Christian. (2015) Sleep Disruption and Daytime Sleepiness Correlating with Disease Severity and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: A Comparison with Healthy Controls. PLoS ONE, 10 (11). e0143293.

Marti, Patricia and Stein, Claudia and Blumer, Tanja and Abraham, Yann and Dill, Michael T. and Pikiolek, Monika and Orsini, Vanessa and Jurisic, Giorgia and Megel, Philippe and Makowska, Zuzanna and Agarinis, Claudia and Tornillo, Luigi and Bouwmeester, Tewis and Ruffner, Heinz and Bauer, Andreas and Parker, Christian N. and Schmelzle, Tobias and Terracciano, Luigi M. and Heim, Markus H. and Tchorz, Jan S.. (2015) YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors. Hepatology (Baltimore, Md.), 62 (5). pp. 1497-1510.

2014

Bernsmeier, Christine and Calabrese, Diego and Heim, Markus H. and Duong, H. T. F.. (2014) Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1α and dephosphorylation of FoxO1. Journal of Viral Hepatitis, 21 (1). pp. 9-18.

Duong, Francois H. T. and Trincucci, Gaia and Boldanova, Tujana and Calabrese, Diego and Campana, Benedetta and Krol, Ilona and Durand, Sarah C. and Heydmann, Laura and Zeisel, Mirjam B. and Baumert, Thomas F. and Heim, Markus H.. (2014) IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies. Journal of Experimental Medicine, 211 (5). pp. 857-868.

Heim, Markus H. and Thimme, Robert. (2014) Innate and adaptive immune responses in HCV infections. Journal of hepatology, 61 (1 Suppl). S14-S25.

Quagliata, Luca and Matter, Matthias S. and Piscuoglio, Salvatore and Arabi, Leila and Ruiz, Christian and Procino, Alfredo and Kovac, Michal and Moretti, Francesca and Makowska, Zuzanna and Boldanova, Tujana and Andersen, Jesper B. and Hammerle, Monika and Tornillo, Luigi and Heim, Markus H. and Diederichs, Sven and Cillo, Clemente and Terracciano, Luigi M.. (2014) Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. Hepatology, 59 (3). pp. 911-923.

de Bruyn Ouboter, Dirk and Schuster, Thomas B. and Shanker, Vijay and Heim, Markus H. and Meier, Wolfgang. (2014) Multicompartment micelle-structured peptide nanoparticles: a new biocompatible gene- and drug-delivery tool. Journal of Biomedical Materials Research Part A, 102 (4). pp. 1155-1163.

Hoggart, Clive J. and Venturini, Giulia and Mangino, Massimo and Gomez, Felicia and Ascari, Giulia and Zhao, Jing Hua and Teumer, Alexander and Winkler, Thomas W. and Tšernikova, Natalia and Luan, Jian'an and Mihailov, Evelin and Ehret, Georg B. and Zhang, Weihua and Lamparter, David and Esko, Tõnu and Macé, Aurelien and Rüeger, Sina and Bochud, Pierre-Yves and Barcella, Matteo and Dauvilliers, Yves and Benyamin, Beben and Evans, David M. and Hayward, Caroline and Lopez, Mary F. and Franke, Lude and Russo, Alessia and Heid, Iris M. and Salvi, Erika and Vendantam, Sailaja and Arking, Dan E. and Boerwinkle, Eric and Chambers, John C. and Fiorito, Giovanni and Grallert, Harald and Guarrera, Simonetta and Homuth, Georg and Huffman, Jennifer E. and Porteous, David and Generation Scotland Consortium, and LifeLines Cohort study, and Giant Consortium, and Moradpour, Darius and Iranzo, Alex and Hebebrand, Johannes and Kemp, John P. and Lammers, Gert J. and Aubert, Vincent and Heim, Markus H. and Martin, Nicholas G. and Montgomery, Grant W. and Peraita-Adrados, Rosa and Santamaria, Joan and Negro, Francesco and Schmidt, Carsten O. and Scott, Robert A. and Spector, Tim D. and Strauch, Konstantin and Völzke, Henry and Wareham, Nicholas J. and Yuan, Wei and Bell, Jordana T. and Chakravarti, Aravinda and Kooner, Jaspal S. and Peters, Annette and Matullo, Giuseppe and Wallaschofski, Henri and Whitfield, John B. and Paccaud, Fred and Vollenweider, Peter and Bergmann, Sven and Beckmann, Jacques S. and Tafti, Mehdi and Hastie, Nicholas D. and Cusi, Daniele and Bochud, Murielle and Frayling, Timothy M. and Metspalu, Andres and Jarvelin, Marjo-Riitta and Scherag, André and Smith, George Davey and Borecki, Ingrid B. and Rousson, Valentin and Hirschhorn, Joel N. and Rivolta, Carlo and Loos, Ruth J. F. and Kutalik, Zoltán. (2014) Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. PLoS Genetics, 10 (7). e1004508.

Dill, Michael T. and Makowska, Zuzanna and Trincucci, Gaia and Gruber, Andreas J. and Vogt, Julia E. and Filipowicz, Magdalena and Calabrese, Diego and Krol, Ilona and Lau, Daryl T. and Terracciano, Luigi and van Nimwegen, Erik and Roth, Volker and Heim, Markus H.. (2014) Pegylated IFN-α regulates hepatic gene expression through transient Jak/STAT activation. Journal of Clinical Investigation, Vol. 124, H. 4. pp. 1568-1581.

Terczyńska-Dyla, Ewa and Bibert, Stephanie and Duong, Francois H. T. and Krol, Ilona and Jørgensen, Sanne and Collinet, Emilie and Kutalik, Zoltán and Aubert, Vincent and Cerny, Andreas and Kaiser, Laurent and Malinverni, Raffaele and Mangia, Alessandra and Moradpour, Darius and Müllhaupt, Beat and Negro, Francesco and Santoro, Rosanna and Semela, David and Semmo, Nasser and Swiss Hepatitis C. Cohort Study Group, and Heim, Markus H. and Bochud, Pierre-Yves and Hartmann, Rune. (2014) Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes. Nature Communications, 5. p. 5699.

Quagliata, Luca and Andreozzi, Mariacarla and Kovac, Michal and Tornillo, Luigi and Makowska, Zuzanna and Moretti, Francesca and Heim, Markus H. and Heinimann, Karl and Piscuoglio, Salvatore and Terracciano, Luigi Maria. (2014) SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules. European Journal of Cancer, 50 (4). pp. 731-738.

Wieland, Stefan and Makowska, Zuzanna and Campana, Benedetta and Calabrese, Diego and Dill, Michael T. and Chung, Josan and Chisari, Francis V. and Heim, Markus H.. (2014) Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver. Hepatology, 59 (6). pp. 2121-2130.

Lucifora, Julie and Xia, Yuchen and Reisinger, Florian and Zhang, Ke and Stadler, Daniela and Cheng, Xiaoming and Sprinzl, Martin F. and Koppensteiner, Herwig and Makowska, Zuzanna and Volz, Tassilo and Remouchamps, Caroline and Chou, Wen-Min and Thasler, Wolfgang E. and Hüser, Norbert and Durantel, David and Liang, T. Jake and Münk, Carsten and Heim, Markus H. and Browning, Jeffrey L. and Dejardin, Emmanuel and Dandri, Maura and Schindler, Michael and Heikenwalder, Mathias and Protzer, Ulrike. (2014) Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science, 343 (6176). pp. 1221-1228.

Balmer, Maria L. and Slack, Emma and de Gottardi, Andrea and Lawson, Melissa A. E. and Hapfelmeier, Siegfried and Miele, Luca and Grieco, Antonio and Van Vlierberghe, Hans and Fahrner, René and Patuto, Nicola and Bernsmeier, Christine and Ronchi, Francesca and Wyss, Madeleine and Stroka, Deborah and Dickgreber, Nina and Heim, Markus H. and McCoy, Kathy D. and Macpherson, Andrew J.. (2014) The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota. Science Translational Medicine, 6 (237). 237ra66.

Lange, Christian M. and Gouttenoire, Jérôme and Duong, François H. T. and Morikawa, Kenichi and Heim, Markus H. and Moradpour, Darius. (2014) Vitamin D receptor and Jak-STAT signaling crosstalk results in calcitriol-mediated increase of hepatocellular response to IFN-α. Journal of Immunology, 192 (12). pp. 6037-6044.

Thimme, Robert and Heim, Markus H. and Baumert, Thomas F. and Nassal, M. and Moradpour, Darius. (2014) [Hepatitis B and C: From molecular virology to new antiviral therapies (part 1)]. Deutsche Medizinische Wochenschrift, 139 (13). pp. 655-659.

2012

Hagiwara, Asami and Cornu, Marion and Cybulski, Nadine and Polak, Pazit and Betz, Charles and Trapani, Francesca and Terracciano, Luigi and Heim, Markus H. and Rüegg, Markus A. and Hall, Michael N.. (2012) Hepatic mTORC2 activates glycolysis and lipogenesis through akt, glucokinase, and SREBP1c. Cell Metabolism, 15 (5). pp. 725-738.

2011

Mueller, Kristina M. and Kornfeld, Jan-Wilhelm and Friedbichler, Katrin and Blaas, Leander and Egger, Gerda and Esterbauer, Harald and Hasselblatt, Peter and Schlederer, Michaela and Haindl, Susanne and Wagner, Kay-Uwe and Engblom, David and Haemmerle, Guenter and Kratky, Dagmar and Sexl, Veronika and Kenner, Lukas and Kozlov, Andrey V. and Terracciano, Luigi and Zechner, Rudolf and Schuetz, Guenther and Casanova, Emilio and Pospisilik, J. Andrew and Heim, Markus H. and Moriggl, Richard. (2011) Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology, Vol. 54, H. 4. pp. 1398-1409.

Trajkovski, Mirko and Hausser, Jean and Soutschek, Jürgen and Bhat, Bal and Akin, Akinc and Zavolan, Mihaela and Heim, Markus H. and Stoffel, Markus. (2011) MicroRNAs 103 and 107 regulate insulin sensitivity. Nature, Vol. 474, H. 7353. pp. 649-653.

2010

Bellecave, Pantxika and Sarasin-Filipowicz, Magdalena and Donzé, Olivier and Kennel, Audrey and Gouttenoire, Jérôme and Meylan, Etienne and Terracciano, Luigi and Tschopp, Jürg and Sarrazin, Christoph and Berg, Thomas and Moradpour, Darius and Heim, Markus H.. (2010) Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system. Hepatology, Vol. 51, H. 4. pp. 1127-1136.

Dufour, Jean-François and Hoppe, Hanno and Heim, Markus H. and Helbling, Beat and Maurhofer, Olivier and Szucs-Farkas, Zsolt and Kickuth, Ralph and Borner, Markus and Candinas, Daniel and Saar, Bettina. (2010) Continuous administration of sorafenib in combination with transarterial chemoembolization in patients with hepatocellular carcinoma : results of a phase I study. The oncologist, Vol. 15, H. 11. pp. 1198-1204.

Duong, Francois H. T. and Christen, Verena and Lin, Shanshan and Heim, Markus H.. (2010) Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair. Hepatology, Vol. 51, No. 3. pp. 741-751.

Ripoli, Maria and D'Aprile, Annamaria and Quarato, Giovanni and Sarasin-Filipowicz, Magdalena and Gouttenoire, Jérôme and Scrima, Rosella and Cela, Olga and Boffoli, Domenico and Heim, Markus H. and Moradpour, Darius and Capitanio, Nazzareno and Piccoli, Claudia. (2010) Hepatitis C virus-linked mitochondrial dysfunction promotes hypoxia-inducible factor 1 alpha-mediated glycolytic adaptation. Journal of virology, Vol. 84, H. 1. pp. 647-660.

Filipowicz, Magdalena and Bernsmeier, Christine and Terracciano, Luigi and Duong, Francois H. T. and Heim, Markus H.. (2010) S-adenosyl-methionine and betaine improve early virological response in chronic hepatitis C patients with previous nonresponse. PLoS ONE, Vol. 5, H. 11 , e15492.

Gonvers, Jean-Jacques and Heim, Markus H. and Cavassini, Matthias and Müllhaupt, Beat and Genné, Daniel and Bernasconi, Enos and Borovicka, Jan and Cerny, Andreas and Chave, Jean-Philippe and Chuard, Christian and Dufour, François and Dutoit, Valérie and Malinverni, Raffaelle and Monnat, Martine and Negro, Francesco and Troilliet, Nicolas and Oneta, Carl. (2010) Treatment of hepatitis C in HCV mono-infected and in HIV-HCV co-infected patients : an open-labelled comparison study. Swiss Medical Weekly, Vol. 140 , w13055.

2009

Sarasin-Filipowicz, Magdalena and Wang, Xueya and Yan, Ming and Duong, Francois H. T. and Poli, Valeria and Hilton, Douglas J. and Zhang, Dong-Er and Heim, Markus H.. (2009) Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Molecular and cellular biology : MCB : a publication of the American Society for Microbiology, Vol. 29. pp. 4841-4851.

Bernsmeier, Christine and Heim, Markus H.. (2009) Insulin resistance in chronic hepatitis C : mechanisms and clinical relevance. Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology, Vol. 139. pp. 678-684.

Tchorz, Jan S. and Kinter, Jochen and Müller, Matthias and Tornillo, Luigi and Heim, Markus H. and Bettler, Bernhard. (2009) Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice. Hepatology : official journal of the American Association for the Study of Liver Diseases, Vol. 50, No. 3. pp. 871-879.

2007

Christen, Verena and Treves, Susan and Duong, Francois H. T. and Heim, Markus H.. (2007) Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A. Hepatology, 46 (2). pp. 558-565.