Items where Author is "Ernst, Beat"
Number of items: 89. 2021Gao, Chao and Stavenhagen, Kathrin and Eckmair, Barbara and McKitrick, Tanya R. and Mehta, Akul Y. and Matsumoto, Yasuyuki and McQuillan, Alyssa M. and Hanes, Melinda S. and Eris, Deniz and Baker, Kelly J. and Jia, Nan and Wei, Mohui and Heimburg-Molinaro, Jamie and Ernst, Beat and Cummings, Richard D.. (2021) Differential recognition of oligomannose isomers by glycan-binding proteins involved in innate and adaptive immunity. Science Advances, 7 (24). eabf6834. Tomašič, Tihomir and Rabbani, Said and Jakob, Roman P. and Reisner, Andreas and Jakopin, Žiga and Maier, Timm and Ernst, Beat and Anderluh, Marko. (2021) Does targeting Arg98 of FimH lead to high affinity antagonists? European Journal of Medicinal Chemistry, 211. p. 113093. Cramer, Jonathan and Aliu, Butrint and Jiang, Xiaohua and Sharpe, Timothy and Pang, Lijuan and Hadorn, Adrian and Rabbani, Said and Ernst, Beat. (2021) Poly-l-lysine Glycoconjugates Inhibit DC-SIGN-mediated Attachment of Pandemic Viruses. ChemMedChem, 16 (15). pp. 2345-2353. Lal, Kanhaya and Bermeo, Rafael and Cramer, Jonathan and Vasile, Francesca and Ernst, Beat and Imberty, Anne and Bernardi, Anna and Varrot, Annabelle and Belvisi, Laura. (2021) Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia cenocepacia*. Chemistry - A European Journal, 27 (40). pp. 10341-10348. Cramer, Jonathan and Lakkaichi, Adem and Aliu, Butrint and Jakob, Roman P. and Klein, Sebastian and Cattaneo, Ivan and Jiang, Xiaohua and Rabbani, Said and Schwardt, Oliver and Zimmer, Gert and Ciancaglini, Matias and Abreu Mota, Tiago and Maier, Timm and Ernst, Beat. (2021) Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2. Journal of the American Chemical Society, 143 (42). pp. 17465-17478. 2020Cramer, Jonathan and Jiang, Xiaohua and Schönemann, Wojciech and Silbermann, Marleen and Zihlmann, Pascal and Siegrist, Stefan and Fiege, Brigitte and Jakob, Roman Peter and Rabbani, Said and Maier, Timm and Ernst, Beat. (2020) Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding. RSC Chemical Biology, 1 (4). pp. 281-287. 2019Dias, Catarina and Matos, Ana M. and Blasquez-Sanchez, Maria T. and Calado, Patricia and Martins, Alice and Daetwyler, Philipp and Ernst, Beat and Macedo, M. Paula and Colabufo, Nicola and Rauter, Amelia. (2019) 2-Deoxyglycosylation towards more effective and bioavailable neuroprotective molecules inspired by nature. Pure and applied chemistry, 91 (7). pp. 1209-1221. Sauer, Maximilian M. and Jakob, Roman P. and Luber, Thomas and Canonica, Fabia and Navarra, Giulio and Ernst, Beat and Unverzagt, Carlo and Maier, Timm and Glockshuber, Rudi. (2019) Binding of the bacterial adhesin FimH to its natural, multivalent high-mannose type glycan targets. Journal of the American Chemical Society, 141 (2). pp. 936-944. Frei, Priska and Silbermann, Marleen and Mühlethaler, Tobias and Jiang, Xiaohua and Schwardt, Oliver and Hevey, Rachel and Ernst, Beat. (2019) Comparison of Affinity Ranking by Target-directed Dynamic Combinatorial Chemistry and Surface Plasmon Resonance. Arkivoc, part iv. pp. 143-167. de Matos, Ana M. and Martins, Alice and Man, Teresa and Evans, David and Walter, Magnus and Oliveira, Maria Conceição and López, Óscar and Fernandez-Bolaños, José G. and Dätwyler, Philipp and Ernst, Beat and Macedo, M. Paula and Contino, Marialessandra and Colabufo, Nicola A. and Rauter, Amélia P.. (2019) Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H; 2; O; 2; - and Aβ; 1-42; -Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells. Pharmaceuticals (Basel, Switzerland), 12 (2). p. 98. Frei, Priska and Hevey, Rachel and Ernst, Beat. (2019) Dynamic Combinatorial Chemistry: A New Methodology Comes of Age. Chemistry (Weinheim an der Bergstrasse, Germany), 25 (1). pp. 60-73. Cramer, Jonathan and Sager, Christoph P. and Ernst, Beat. (2019) Hydroxyl Groups in Synthetic and Natural-Product-Derived Therapeutics: A Perspective on a Common Functional Group. Journal of medicinal chemistry, 62 (20). pp. 8915-8930. Schönemann, Wojciech and Cramer, Jonathan and Mühlethaler, Tobias and Fiege, Brigitte and Silbermann, Marleen and Rabbani, Said and Dätwyler, Philipp and Zihlmann, Pascal and Jakob, Roman P. and Sager, Christoph P. and Smiesko, Martin and Schwardt, Oliver and Maier, Timm and Ernst, Beat. (2019) Improvement of Aglycone π-Stacking Yields Nano- to Subnanomolar FimH Antagonists. ChemMedChem, 14 (7). pp. 749-757. 2 February 2018Rabbani, Said and Fiege, Brigitte and Eris, Deniz and Silbermann, Marleen and Jakob, Roman Peter and Navarra, Giulio and Maier, Timm and Ernst, Beat. (2018) Conformational Switch of the Bacterial Adhesin FimH in the Absence of the Regulatory Domain: Engineering a Minimalistic Allosteric System. Journal of Biological Chemistry, 293 (5). pp. 1835-1849. 2018Zihlmann, Pascal and Silbermann, Marleen and Sharpe, Timothy and Jiang, Xiaohua and Mühlethaler, Tobias and Jakob, Roman P. and Rabbani, Said and Sager, Christoph P. and Frei, Priska and Pang, Lijuan and Maier, Timm and Ernst, Beat. (2018) KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists. Chemistry (Weinheim an der Bergstrasse, Germany), 24. pp. 1-10. Guo, Tianlin and Dätwyler, Philipp and Demina, Ekaterina and Richards, Michele R. and Ge, Peng and Zou, Chunxia and Zheng, Ruixiang and Fougerat, Anne and Pshezhetsky, Alexey V. and Ernst, Beat and Cairo, Christopher W.. (2018) Selective Inhibitors of Human Neuraminidase 3. Journal of medicinal chemistry, 61 (5). pp. 1990-2008. Sager, Christoph P. and Fiege, Brigitte and Zihlmann, Pascal and Vannam, Raghu and Rabbani, Said and Jakob, Roman P. and Preston, Roland C. and Zalewski, Adam and Maier, Timm and Peczuh, Mark W. and Ernst, Beat. (2018) The price of flexibility - a case study on septanoses as pyranose mimetics. Chemical Science, 9 (3). pp. 646-654. 2017Aeschbacher, Thomas and Zierke, Mirko and Smieško, Martin and Collot, Mayeul and Mallet, Jean-Maurice and Ernst, Beat and Allain, Frédéric H.-T. and Schubert, Mario. (2017) A Secondary Structural Element in a Wide Range of Fucosylated Glycoepitopes. Chemistry - A European Journal, 23 (48). pp. 11598-11610. Navarra, Giulio and Zihlmann, Pascal and Jakob, Roman P. and Stangier, Katia and Preston, Roland C. and Rabbani, Said and Smiesko, Martin and Wagner, Bea and Maier, Timm and Ernst, Beat. (2017) Carbohydrate-Lectin Interactions - An Unexpected Contribution to Affinity. ChemBioChem, 18 (6). pp. 539-544. Pang, Lijuan and Bezençon, Jacqueline and Kleeb, Simon and Rabbani, Said and Sigl, Anja and Smiesko, Martin and Sager, Christoph P. and Eris, Deniz and Schwardt, Oliver and Ernst, Beat. (2017) FimH antagonists - solubility vs. permeability. In: Carbohydrate Chemistry. London, pp. 248-273. Rabbani, Said and Krammer, Eva-Maria and Goedele, Roos and Zalewski, Adam and Preston, Roland and Eid, Sameh and Zihlmann, Pascal and Prévost, Martine and Lensink, Marc F. and Thompson, Andrew and Ernst, Beat and Bouckaert, Julie. (2017) Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding. IU Cr J, 4 (1). pp. 7-23. Herrendorff, Ruben and Hänggi, Pascal and Pfister, Hélène and Yang, Fan and Demeestere, Delphine and Hunziker, Fabienne and Frey, Samuel and Schaeren-Wiemers, Nicole and Steck, Andreas J. and Ernst, Beat. (2017) Selective in vivo removal of pathogenic anti-MAG autoantibodies, an antigen-specific treatment option for anti-MAG neuropathy. Proceedings of the National Academy of Sciences, 114 (18). E3689-E3698. Frei, Priska and Pang, Lijuan and Silbermann, Marleen and Eriş, Deniz and Mühlethaler, Tobias and Schwardt, Oliver and Ernst, Beat. (2017) Target-directed Dynamic Combinatorial Chemistry: A Study on Potentials and Pitfalls as Exemplified on a Bacterial Target. Chemistry - A European Journal, 23 (48). pp. 11570-11577. Mayer, Katharina and Eris, Deniz and Schwardt, Oliver and Sager, Christoph P. and Rabbani, Said and Kleeb, Simon and Ernst, Beat. (2017) Urinary Tract Infection: Which Conformation of the Bacterial Lectin FimH Is Therapeutically Relevant? Journal of Medicinal Chemistry, 60 (13). pp. 5646-5662. Sager, Christoph P. and Eriş, Deniz and Smieško, Martin and Hevey, Rachel and Ernst, Beat. (2017) What contributes to an effective mannose recognition domain? Beilstein Journal of Organic Chemistry, 13. pp. 2584-2595. February 2016Preston, Roland C. and Jakob, Roman P. and Binder, Florian P. C. and Sager, Christoph P. and Ernst, Beat and Maier, Timm. (2016) E-selectin ligand complexes adopt an extended high-affinity conformation. Journal of Molecular Cell Biology, 8 (1). pp. 62-72. 2016Teppner, Marieke and Boess, Franziska and Ernst, Beat and Pähler, Axel. (2016) Biomarkers of Flutamide-Bioactivation and Oxidative Stress In Vitro and In Vivo. Drug Metabolism and Disposition, 44 (4). pp. 560-169. Sauer, Maximilian M. and Jakob, Roman P. and Eras, Jonathan and Baday, Sefer and Eris, Deniz and Navarra, Giulio and Bernèche, Simon and Ernst, Beat and Maier, Timm and Glockshuber, Rudi. (2016) Catch-bond mechanism of the bacterial adhesin FimH. Nature communications, 7. p. 10738. Kleeb, Simon and Jiang, Xiaohua and Frei, Priska and Sigl, Anja and Bezençon, Jacqueline and Bamberger, Karen and Schwardt, Oliver and Ernst, Beat. (2016) FimH Antagonists: Phosphate Prodrugs Improve Oral Bioavailability. Journal of Medicinal Chemistry, 59 (7). pp. 3163-3182. Wipf, Mathias and Stoop, Ralph L. and Navarra, Giulio and Rabbani, Said and Ernst, Beat and Bedner, Kristine and Schonenberger, Christian and Calame, Michel. (2016) Label-Free FimH Protein Interaction Analysis Using Silicon Nanoribbon BioFETs. ACS Sensors, 1 (6). pp. 781-788. Schönemann, Wojciech and Kleeb, Simon and Dätwyler, Philipp and Schwardt, Oliver and Ernst, Beat. (2016) Prodruggability of Carbohydrates - Oral FimH Antagonists. Canadian Journal of Chemistry, 94 (11). pp. 909-919. Teppner, Marieke and Zell, Manfred and Husser, Christophe and Ernst, Beat and Pähler, Axel. (2016) Quantitative profiling of prostaglandins as oxidative stress biomarkers in vitro and in vivo by negative ion online solid phase extraction - Liquid chromatography-tandem mass spectrometry. Analytical Biochemistry, 498. pp. 68-77. Pröpster, Johannes M. and Yang, Fan and Rabbani, Said and Ernst, Beat and Allain, Frédéric H.-T. and Schubert, Mario. (2016) Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8. Proceedings of the National Academy of Sciences of the United States of America, 113 (29). pp. 4170-4179. Eris, Deniz and Preston, Roland C. and Scharenberg, Meike and Hulliger, Fabian and Abgottspon, Daniela and Pang, Lijuan and Jiang, Xiaohua and Schwardt, Oliver and Ernst, Beat. (2016) The Conformational Variability of FimH: Which Conformation Represents the Therapeutic Target? ChemBioChem, 17 (11). pp. 1012-1020. 26 May 2015Marelli, Udaya Kiran and Bezençon, Jacqueline and Puig, Eduard and Ernst, Beat and Kessler, Horst. (2015) Enantiomeric cyclic peptides with different Caco-2 permeability suggest carrier-mediated transport. Chemistry - A European Journal, 21 (22). pp. 8023-8027. May 2015Pröpster, Johannes M. and Yang, Fan and Ernst, Beat and Allain, Frédéric H.-T. and Schubert, Mario. (2015) Functional Siglec lectin domains from soluble expression in the cytoplasm of Escherichia coli. Protein Expression and Purification, 109. pp. 14-22. 2015Cowan, Noemi and Dätwyler, Philipp and Ernst, Beat and Wang, Chunkai and Vennerstrom, Jonathan L. and Spangenberg, Thomas and Keiser, Jennifer. (2015) Activities of N,N'-Diarylurea MMV665852 analogs against Schistosoma mansoni. Antimicrobial Agents and Chemotherapy, 59 (4). pp. 1935-1941. Kleeb, Simon and Pang, Lijuan and Mayer, Katharina and Eris, Deniz and Sigl, Anja and Preston, Roland C. and Zihlmann, Pascal and Sharpe, Timothy and Jakob, Roman P. and Abgottspon, Daniela and Hutter, Aline S. and Scharenberg, Meike and Jiang, Xiaohua and Navarra, Giulio and Rabbani, Said and Smiesko, Martin and Lüdin, Nathalie and Bezençon, Jacqueline and Schwardt, Oliver and Maier, Timm and Ernst, Beat. (2015) FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile. Journal of Medicinal Chemistry, 58 (5). pp. 2221-2239. Schwardt, Oliver and Kelm, Soerge and Ernst, Beat. (2015) SIGLEC-4 (MAG) Antagonists: From the Natural Carbohydrate Epitope to Glycomimetics. Topics in Current Chemistry, 367. pp. 151-200. Fiege, Brigitte and Rabbani, Said and Preston, Roland C. and Jakob, Roman P. and Zihlmann, Pascal and Schwardt, Oliver and Jiang, Xiaohua and Maier, Timm and Ernst, Beat. (2015) The Tyrosine Gate of the Bacterial Lectin FimH : a Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. ChemBioChem, 16 (8). pp. 1235-1246. 2014Tomasic, Tihomir and Rabbani, Said and Gobec, Martina and Mlinaric Rascan, Irena and Podlipnik, Crtomir and Ernst, Beat and Anderluh, Marko. (2014) Branched α-D-mannopyranosides : a new class of potent FimH antagonists. MedChemComm , 5 (8). pp. 1247-1253. Preston, Roland C. and Rabbani, Said and Binder, Florian P. C. and Moes, Suzette and Magnani, John L. and Ernst, Beat. (2014) Implications of the E-selectin S128R mutation for drug discovery. Glycobiology, 24 (7). pp. 592-601. Bezençon, Jacqueline and Wittwer, Matthias B. and Cutting, Brian and Smieško, Martin and Wagner, Bjoern and Kansy, Manfred and Ernst, Beat. (2014) pKa determination by 1H NMR spectroscopy - an old methodology revisited. Journal of Pharmaceutical and Biomedical Analysis, 93. pp. 147-155. 2013Eid, Sameh and Zalewski, Adam and Smiesko, Martin and Ernst, Beat and Vedani, Angelo. (2013) A molecular-modeling toolbox aimed at bridging the gap between medicinal chemistry and computational sciences. International Journal of Molecular Sciences, 14 (1). pp. 684-700. Ernst, Beat and Sigl, Anja. (2013) FimH-Antagonisten: Eine neue Option für die Therapie von Harnwegsinfektionen. Swiss Medical Forum, 13 (50). pp. 1045-1046. Scharenberg, Meike and Jiang, Xiaohua and Pang, Lijuan and Navarra, Giulio and Rabbani, Said and Binder, Florian and Schwardt, Oliver and Ernst, Beat. (2013) Kinetic properties of carbohydrate–lectin interactions: FimH antagonists. ChemMedChem, 9 (1). pp. 78-83. Egger, Jonas and Weckerle, Céline and Cutting, Brian and Schwardt, Oliver and Rabbani, Said and Lemme, Katrin and Ernst, Beat. (2013) Nanomolar E-selectin antagonists with prolonged half-lives by a fragment-based approach. Journal of the American Chemical Society, 135 (26). pp. 9820-9828. Zierke, Mirko and Smiesko, Martin and Rabbani, Said and Aeschbacher, Thomas and Cutting, Brian and Allain, Frédéric H.-T. and Schubert, Mario and Ernst, Beat. (2013) Stabilization of branched oligosaccharides : Lewisx benefits from a non-conventional C-H...O hydrogen bond. Journal of the American Chemical Society, 135 (36). pp. 13464-13472. 2012Müller, Gerhard and Ernst, Beat. (2012) Alpine Drug Discovery Summit : 10th Swiss Course on Medicinal Chemistry. ChemMedChem, 7 (12). pp. 2237-2240. Jiang, Xiaohua and Abgottspon, Daniela and Kleeb, Simon and Rabbani, Said and Scharenberg, Meike and Wittwer, Matthias and Haug, Martina and Schwardt, Oliver and Ernst, Beat. (2012) Anti-adhesion therapy for urinary tract infections - a balanced PK/PD-profile proved to be key for success. Journal of Medicinal Chemistry, 55 (10). pp. 4700-4713. Titz, Alexander and Marra, Alberto and Cutting, Brian and Smiesko, Martin and Papandreou, George and Dondoni, Alessandro and Ernst, Beat. (2012) Conformational constraints : nature does it best with Sialyl Lewisx. European Journal of Organic Chemistry, 2012 (28). pp. 5534-5539. Gratieri, Taís and Wagner, Beatrice and Kalaria, Dhaval and Ernst, Beat and Kalia, Yogeshvar N.. (2012) Cutaneous iontophoretic delivery of CGP69669A, a silalyl Lewisx mimetic, in vitro. Experimental Dermatology, 21 (3). pp. 226-228. Pang, Lijuan and Kleeb, Simon and Lemme, Katrin and Rabbani, Said and Scharenberg, Meike and Zalewski, Adam and Schädler, Florentina and Schwardt, Oliver and Ernst, Beat. (2012) FimH Antagonists: Structure-Activity and Structure-Property Relationships for Biphenyl α-D-Mannopyranosides. ChemMedChem, 7 (8). pp. 1404-1422. Mesch, Stefanie and Lemme, Katrin and Wittwer, Matthias and Koliwer-Brandl, Hendrik and Schwardt, Oliver and Kelm, Sorge and Ernst, Beat. (2012) From a Library of MAG Antagonists to Nanomolar CD22 Ligands. ChemMedChem, 7 (1). pp. 134-143. Abgottspon, Daniela and Ernst, Beat. (2012) In vivo evaluation of FimH antagonists – a novel class of antimicrobials for the treatment of urinary tract infection. Chimia, 66 (4). pp. 166-169. Galan, M. Carmen and Tran, Anh Tuan and Bromfield, Karen and Rabbani, Said and Ernst, Beat. (2012) Ionic-liquid-based MS probes for the chemo-enzymatic synthesis of oligosaccharides. Organic and Biomolecular Chemistry, 10 (35). pp. 7091-7097. Schwizer, Daniel and Patton, John T. and Cutting, Brian and Smiesko, Martin and Wagner, Beatrice and Kato, Ako and Weckerle, Céline and Binder, Florian P. C. and Rabbani, Said and Schwardt, Oliver and Magnani, John L. and Ernst, Beat. (2012) Pre-organization of the core structure of E-selectin antagonists. Chemistry - A European Journal, 18 (5). pp. 1342-1351. Binder, Florian P. C. and Lemme, Katrin and Preston, Roland C. and Ernst, Beat. (2012) Sialyl Lewisx – a “Pre-organized Water Oligomer”? Angewandte Chemie International Edition, 51 (29). pp. 7327-7331. 2011Scharenberg, Meike and Abgottspon, Daniela and Cicek, Evelin and Jiang, Xiaohua and Schwardt, Oliver and Rabbani, Said and Ernst, Beat. (2011) A Flow Cytometry-based Assay for Screening FimH Antagonists. Assay and Drug Development Technologies, 9 (5). pp. 455-464. Rossato, G. and Ernst, Beat and Vedani, Angelo and Smiesko, Martin. (2011) AcquaAlta: a directional approach to the solvation of ligand-protein complexes. Journal of Chemical Information and Modeling, 51 (8). pp. 1867-1881. Ernst, Beat. (2011) Deal watch: Pfizer deal for selectin inhibitor highlights potential of glycomimetic drugs. Nature Reviews. Drug Discovery, 10. p. 890. Schwardt, Oliver and Rabbani, Said and Hartmann, Margrit and Abgottspon, Daniela and Wittwer, Matthias and Kleeb, Simon and Zalewski, Adam and Smiesko, Martin and Cutting, Brian and Ernst, Beat. (2011) Design, Synthesis and Biological Evaluation of Mannosyl Triazoles as FimH Antagonists. Bioorganic & Medicinal Chemistry, 19 (21). pp. 6454-6473. Binder, Florian and Ernst, Beat. (2011) E- and P-Selectin : Differences, Similarities and Implications for the Design of P-Selectin Antagonists. Chimia, 65 (4). pp. 210-213. von der Lieth, C. -W. and Freire, A. A. and Blank, D. and Campbell, M. P. and Ceroni, A. and Damerell, D. D. and Dell, A. and Dwek, R. A. and Ernst, Beat and Frank, M. and Geyer, H. and Geyer, R. and Harrison, M. J. and Henrick, K. and Herget, M. and Hull, W. E. and Ionides, J. and Joshi, H. and Kamerling, J. P. and Leeflang, B. R. and Lütteke, T. and Lundborg, M. and Maass, K. and Merry, A. and Ranzinger, R. and Rosen, J. and Royle, L. and Rudd, P. M. and Schloissnig, S. and Stenutz, R. and Vrancken, W. F. and Widmalm, G. and Haslam, S. M.. (2011) EUROCarbDB: An open-access platform for glycoinformatics. Glycobiology, 21 (4). pp. 493-502. Stefanescu, R. and Born, R. and Moise, A. and Ernst, Beat. (2011) Epitope structure of the carbohydrate recognition domain of asialoglycoprotein receptor to a monoclonal antibody revealed by high resolution proteolytic excision mass spectrometry. Journal of the American Society for Mass Spectrometry, 22 (1). pp. 148-157. Zeng, Y. and Rademacher, C. and Nycholat, C. M. and Futakawa, S. and Lemme, K. and Ernst, Beat and Paulson, J. C.. (2011) High affinity sialoside ligands of myelin associated glycoprotein. Bioorganic and Medicinal Chemistry Letters, 21 (17). pp. 5045-5049. 2010Ernst, Beat. (2010) Brisante Infos im "Zuckerguss". Chemische Rundschau, 63 (10 (5.10.10)). pp. 35-37. Dutzler, R. and Ernst, Beat and Hediger, M. A. and Keppler, D. and Mohr, P. and Neidhart, W. and Märki, H. P.. (2010) Channels and transporters. Chimia, 64. pp. 662-668. Schwardt, Oliver and Koliwer-Brandl, Hendrik and Zimmerli, Raphael and Mesch, Stefanie and Rossato, Gianluca and Spreafico, Morena and Vedani, Angelo and Kelm, Sorge and Ernst, Beat. (2010) Design, synthesis, biological evaluation and modeling of a non-carbohydrate antagonist of the myelin-associated glycoprotein. Bioorganic & Medicinal Chemistry, 18 (20). pp. 7239-7251. Abgottspon, Daniela and Rölli, Gina and Hosch, Lucie and Steinhuber, Andrea and Jiang, Xiaohua and Schwardt, Oliver and Cutting, Brian and Smiesko, Martin and Jenal, Urs and Ernst, Beat and Trampuz, Andrej. (2010) Development of an aggregation assay to screen FimH antagonists. Journal of Microbiological Methods, 82 (3). pp. 249-255. Rabbani, Said and Jiang, Xiaohua and Schwardt, Oliver and Ernst, Beat. (2010) Expression of the Carbohydrate Recognition Domain of FimH and Development of a Competitive Binding Assay. Analytical Biochemistry , 407. pp. 188-195. Klein, Tobias and Abgottspon, Daniela and Wittwer, Matthias and Rabbani, Said and Herold, Janno and Jiang, Xiaohua and Kleeb, Simon and Lüthi, Christine and Scharenberg, Meike and Bezençcon, Jacqueline and Gubler, Erich and Pang, Lijuan and Smiesko, Martin and Cutting, Brian and Schwardt, Oliver and Ernst, Beat. (2010) FimH Antagonists for the Oral Treatment of Urinary Tract Infections : From Design and Synthesis to In Vitro and In Vivo Evaluation. Journal of Medicinal Chemistry, 53 (24). pp. 8627-8641. Ernst, Beat and Schwardt, Oliver and Mesch, Stefanie and Wittwer, Matthias and Rossato, Gianluca and Vedani, Angelo. (2010) From the ganglioside GQ1ba to glycomimetic antagonists of the myelin-associated glycoprotein (MAG). Chimia, 64 (1-2). pp. 17-22. Chang, J. and Patton, J. T. and Sarkar, A. and Ernst, Beat and Magnani, J. L. and Frenette, P. S.. (2010) GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice. Blood, 116 (10). pp. 1779-1786. Perchuc, A. M. and Menin, L. and Favreau, P. and Bühler, B. and Bulet, P. and Schöni, R. and Wilmer, M. and Ernst, Beat and Stöcklin, R.. (2010) Isolation and characterization of two new Lys49 PLA2s with heparin neutralizing properties from Bothrops moojeni snake venom. Toxicon, 55 (6). pp. 1080-1092. Mesch, Stefanie and Lemme, Katrin and Koliwer-Brandl, Hendrik and Strasser, Daniel and Schwardt, Oliver and Kelm, Sorge and Ernst, Beat. (2010) Kinetic and thermodynamic properties of MAG antagonists. Carbohydrate Research, 345 (10). pp. 1348-1359. Vögtli, Alexander and Ernst, Beat. (2010) Moderne Pharmakokinetik : Transport durch Membranen. Weinheim. Demler, C. and Bühler, B. and Menin, L. and Stöcklin, R. and Wilmer, M. and Ernst, Beat and Perchuc, A. M.. (2010) Platelet-active substances in the venom of Bothrops moojeni snake : a novel evaluation method using whole blood aggregometry. Platelets, 21 (1). pp. 20-28. Rossato, Gianluca and Ernst, Beat and Smiesko, Martin and Spreafico, Morena and Vedani, Angelo. (2010) Probing small-molecule binding to cytochrome P450 2D6 and 2C9: an in silico protocol for generating toxicity alerts. ChemMedChem, 5 (12). pp. 2088-2101. Titz, Alexander and Patton, John and Smiesko, Martin and Radic, Zorana and Schwardt, Oliver and Magnani, John L. and Ernst, Beat. (2010) Probing the Carbohydrate Recognition Domain of E-Selectin : The Importance of the Acid Orientation in sLex Mimetics. Bioorganic & Medicinal Chemistry, 18 (1). pp. 19-27. 2009Stokmaier, Daniela and Khorev, Oleg and Böni, F. and Gentner, M. and Cutting, Brian and Born, Rita and Schwingruber, K. and Ernst, T. O. G. and Wittwer, Matthias and Ricklin, Daniel and Spreafico, Morena and Vedani, Angelo and Rabbani, Said and Schwardt, Oliver and Ernst, Beat. (2009) Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R). Bioorganic & Medicinal Chemistry, 17 (20). pp. 7254-7264. Ernst, Beat and Magnani, John. (2009) From carbohydrate leads to glycomimetic drugs. Nature Reviews. Drug Discovery, 8. pp. 661-677. Magnani, John L. and Ernst, Beat. (2009) Glycomimetic Drugs : A New Source of Therapeutic Opportunities. Discovery Medicine, 8 (43). pp. 247-252. Stöckli, Andreas and Studer, M. and Cutting, Brian and Ernst, Beat. (2009) Interpretation of 13C-NMR spectra by artificial neural network techniques (NeuroCarb). In: Bioinformatics for Glycobiology and Glycomics. Chichester, pp. 321-334. Spreafico, Morena and Ernst, Beat and Lill, Markus A. and Smiesko, Martin and Vedani, Angelo. (2009) Mixed-Model QSAR at the Glucocorticoid Receptor: Predicting the Binding Mode and Affinity of Psychotropic Drugs. ChemMedChem, 4 (1). pp. 100-109. Peristera, Ourania and Spreafico, Morena and Smiesko, Martin and Ernst, Beat and Vedani, Angelo.. (2009) Mixed-model QSAR at the human mineralocorticoid receptor : Predicting binding mode and affinity of anabolic steroids. Toxicology Letters, 189 (3). pp. 219-224. Su, Z. and Wagner, Bea and Cocinero, E. J. and Ernst, Beat and Simons, J.. (2009) The intrinsic conformation of a Lewis antigen : The Lewisx trisaccharide. Chemical Physics Letters, 477 (4-6). pp. 365-368. 2003K. Lichtsteiner, Salome and Vögtli, Alexander and Weber, Christina and Burkhart, Helmar and Rizzotti, Sven and Folkers, Gerd and Khov-Tran, Van Van and Neier, Reinhard and Ernst, Beat. (2003) Pharmasquare (Pharma²). Chimia, 57 (3). pp. 116-120. K. Lichtsteiner, Salome and Utelli, Anna-Barbara and Vögtli, Alexander and Weber, Christina and Burkhart, Helmar and Rizzotti, Sven and Folkers, Gerd and Khov-Tran, Van Van and Bourry, Anne and Neier, Reinhard and Ernst, Beat. (2003) pharma²- Blended Learning-Konzept für pharmazeutische Wissenschaften. In: Shaping innovations - elearning as a catalyst for a new teaching and learning culture?. St. Gallen. |
