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Ham, Daniel J. and Börsch, Anastasyia and Chojnowska, Kathrin and Lin, Shuo and Leuchtmann, Aurel B. and Ham, Alexander S. and Thürkauf, Marco and Delezie, Julien and Furrer, Regula and Burri, Dominik and Sinnreich, Michael and Handschin, Christoph and Tintignac, Lionel A. and Zavolan, Mihaela and Mittal, Nitish and Rüegg, Markus A.. (2021) Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle.

Kaiser, Marco S. and Milan, Giulia and Lin, Shuo and Oliveri, Filippo and Chojnowska, Kathrin and Tintignac, Lionel A. and Mittal, Nitish and Zimmerli, Christian E. and Glass, David J. and Zavolan, Mihaela and Ham, Daniel J. and Rüegg, Markus A.. (2021) Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis. bioRxiv. pp. 1-39.

Yes

Reinhard, Judith R. and Porrello, Emanuela and Lin, Shuo and Pelczar, Pawel and Previtali, Stefano C. and Rüegg, Markus A.. (2023) Nerve pathology is prevented by linker proteins in mouse models for LAMA2-related muscular dystrophy. PNAS Nexus, 2 (4). pgad083.

Thürkauf, Marco and Lin, Shuo and Oliveri, Filippo and Grimm, Dirk and Platt, Randall J. and Rüegg, Markus A.. (2023) Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9. Nature communications, 14 (1). p. 6116.

Ham, Daniel J. and Börsch, Anastasiya and Chojnowska, Kathrin and Lin, Shuo and Leuchtmann, Aurel B. and Ham, Alexander S. and Thürkauf, Marco and Delezie, Julien and Furrer, Regula and Burri, Dominik and Sinnreich, Michael and Handschin, Christoph and Tintignac, Lionel A. and Zavolan, Mihaela and Mittal, Nitish and Rüegg, Markus A.. (2022) Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. Nature Communications, 13. p. 2025.

Blandino-Rosano, Manuel and Scheys, Joshua O. and Werneck-de-Castro, Joao Pedro and Louzada, Ruy A. and Almaça, Joana and Leibowitz, Gil and Rüegg, Markus A. and Hall, Michael N. and Bernal-Mizrachi, Ernesto. (2022) Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling. American Journal of Physiology, Endocrinology and Metabolism, 323 (2). E133-E144.

Kaiser, Marco S. and Milan, Giulia and Ham, Daniel J. and Lin, Shuo and Oliveri, Filippo and Chojnowska, Kathrin and Tintignac, Lionel A. and Mittal, Nitish and Zimmerli, Christian E. and Glass, David J. and Zavolan, Mihaela and Rüegg, Markus A.. (2022) Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis. Communications biology, 5 (1). p. 1141.

Börsch, Anastasiya and Ham, Daniel J. and Mittal, Nitish and Tintignac, Lionel A. and Migliavacca, Eugenia and Feige, Jérôme N. and Rüegg, Markus A. and Zavolan, Mihaela. (2021) Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia. Communications Biology, 4 (1). p. 194.

Previtali, Stefano C. and Cohn, Ronald D. and Ruegg, Markus A.. (2021) Editorial: Current Insights Into LAMA2 Disease. Frontiers in molecular neuroscience, 14. p. 780635.

Ding, Xiaolei and Willenborg, Sebastian and Bloch, Wilhelm and Wickström, Sara A. and Wagle, Prerana and Brodesser, Susanne and Roers, Axel and Jais, Alexander and Brüning, Jens C. and Hall, Michael N. and Rüegg, Markus A. and Eming, Sabine A.. (2020) Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. Journal of Allergy and Clinical Immunology, 145 (1). pp. 283-300.E8.

Ham, Alexander S. and Chojnowska, Kathrin and Tintignac, Lionel A. and Lin, Shuo and Schmidt, Alexander and Ham, Daniel J. and Sinnreich, Michael and Rüegg, Markus A.. (2020) mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice. Journal of Cachexia, Sarcopenia and Muscle, 11 (1). pp. 259-273.

Pereira, Jorge A. and Gerber, Joanne and Ghidinelli, Monica and Gerber, Daniel and Tortola, Luigi and Ommer, Andrea and Bachofner, Sven and Santarella, Francesco and Tinelli, Elisa and Lin, Shuo and Rüegg, Markus A. and Kopf, Manfred and Toyka, Klaus V. and Suter, Ueli. (2020) Mice carrying an analogous heterozygous Dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy. Human Molecular Genetics, 29 (8). pp. 1253-1273.

Ham, Daniel J. and Börsch, Anastasiya and Lin, Shuo and Thürkauf, Marco and Weihrauch, Martin and Reinhard, Judith R. and Delezie, Julien and Battilana, Fabienne and Wang, Xueyong and Kaiser, Marco S. and Guridi, Maitea and Sinnreich, Michael and Rich, Mark M. and Mittal, Nitish and Tintignac, Lionel A. and Handschin, Christoph and Zavolan, Mihaela and Rüegg, Markus A.. (2020) The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia. Nature Communications, 11 (1). p. 4510.

Castets, Perrine and Ham, Daniel J. and Rüegg, Markus A.. (2020) The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player? Frontiers in molecular neuroscience, 13. p. 162.

Rion, Nathalie and Castets, Perrine and Lin, Shuo and Enderle, Leonie and Reinhard, Judith R. and Eickhorst, Christopher and Rüegg, Markus A.. (2019) mTOR controls embryonic and adult myogenesis via mTORC1. Development, 146 (7). pp. 1-15.

Donadon, Irving and Bussani, Erica and Riccardi, Federico and Licastro, Danilo and Romano, Giulia and Pianigiani, Giulia and Pinotti, Mirko and Kostantinova, Pavlina and Evers, Melvin and Lin, Shuo and Rüegg, Markus A. and Pagani, Franco. (2019) Rescue of spinal muscular atrophy mouse models with AAV9-Exon-specific U1 snRNA. Nucleic acids research, 47 (14). pp. 7618-7632.

Delezie, Julien and Weihrauch, Martin and Maier, Geraldine and Tejero, Rocío and Ham, Daniel J. and Gill, Jonathan F. and Karrer-Cardel, Bettina and Rüegg, Markus A. and Tabares, Lucía and Handschin, Christoph. (2019) BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. Proceedings of the National Academy of Sciences (PNAS), 116 (32). pp. 16111-16120.

Castets, Perrine and Rion, Nathalie and Théodore, Marine and Falcetta, Denis and Lin, Shuo and Reischl, Markus and Wild, Franziska and Guérard, Laurent and Eickhorst, Christopher and Brockhoff, Marielle and Guridi, Maitea and Ibebunjo, Chikwendu and Cruz, Joseph and Sinnreich, Michael and Rudolf, Rüdiger and Glass, David J. and Rüegg, Markus A.. (2019) mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4. Nature communications, 10 (1). p. 3187.

Rion, Nathalie and Castets, Perrine and Lin, Shuo and Enderle, Leonie and Reinhard, Judith R. and Rüegg, Markus A.. (2019) mTORC2 affects the maintenance of the muscle stem cell pool. Skeletal Muscle, 9 (1). p. 30.

Boido, Marina and De Amicis, Elena and Valsecchi, Valeria and Trevisan, Marco and Ala, Ugo and Ruegg, Markus A. and Hettwer, Stefan and Vercelli, Alessandro. (2018) Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy. Frontiers in cellular neuroscience, 12. p. 17.

van Putten, Maaike and Aartsma-Rus, Annemieke and Grounds, Miranda D. and Kornegay, Joe N. and Mayhew, Anna and Gillingwater, Thomas H. and Takeda, Shin'ichi and Rüegg, Markus A. and De Luca, Annamaria and Nagaraju, Kanneboyina and Willmann, Raffaella. (2018) Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, The Netherlands. Journal of Neuromuscular Diseases, 5 (1). pp. 29-34.

Zainul, Zarin and Heikkinen, Anne and Koivisto, Hennariikka and Rautalahti, Iina and Kallio, Mika and Lin, Shuo and Härönen, Heli and Norman, Oula and Rüegg, Markus A. and Tanila, Heikki and Pihlajaniemi, Taina. (2018) Collagen XIII Is Required for Neuromuscular Synapse Regeneration and Functional Recovery after Peripheral Nerve Injury. The Journal of neuroscience, 38 (17). pp. 4243-4258.

Yurchenco, Peter D. and McKee, Karen K. and Reinhard, Judith R. and Rüegg, Markus A.. (2018) Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies. Matrix biology : journal of the International Society for Matrix Biology, 71-72. pp. 174-187.

Martin, Sally K. and Fitter, Stephen and El Khawanky, Nadia and Grose, Randall H. and Walkley, Carl R. and Purton, Louise E. and Ruegg, Markus A. and Hall, Michael N. and Gronthos, Stan and Zannettino, Andrew C. W.. (2018) mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis. Scientific Reports, 8 (1). p. 14501.

Brockhoff, Marielle and Rion, Nathalie and Chojnowska, Kathrin and Wiktorowicz, Tatiana and Eickhorst, Christopher and Erne, Beat and Frank, Stephan and Angelini, Corrado and Furling, Denis and Rüegg, Markus A. and Sinnreich, Michael and Castets, Perrine. (2017) Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I. Journal of Clinical Investigation, 127 (2). pp. 549-563.

McKee, Karen K. and Crosson, Stephanie C. and Meinen, Sarina and Reinhard, Judith R. and Rüegg, Markus A. and Yurchenco, Peter D.. (2017) Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype. Journal of Clinical Investigation, 127 (3). pp. 1075-1089.

Rion, Nathalie and Rüegg, Markus A.. (2017) LncRNA-encoded peptides: More than translational noise? Cell Research, 27 (5). pp. 604-605.

Willmann, Raffaella and Gordish-Dressman, Heather and Meinen, Sarina and Rüegg, Markus A. and Yu, Qing and Nagaraju, Kanneboyina and Kumar, Ayar and Girgenrath, Mahasweta and Coffey, Caroline B. M. and Cruz, Vivian and Van Ry, Pam M. and Bogdanik, Laurent and Lutz, Cathleen and Rutkowski, Anne and Burkin, Dean J.. (2017) Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy. Journal of Neuromuscular Diseases, 4 (2). pp. 115-126.

Fitter, Stephen and Matthews, Mary P. and Martin, Sally K. and Xie, Jianling and Ooi, Soo Siang and Walkley, Carl R. and Codrington, John D. and Ruegg, Markus A. and Hall, Michael N. and Proud, Christopher G. and Gronthos, Stan and Zannettino, Andrew C. W.. (2017) mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Molecular and Cellular Biology, 37 (7). e00668-16.

Reinhard, Judith R. and Lin, Shuo and McKee, Karen K. and Meinen, Sarina and Crosson, Stephanie C. and Sury, Maurizio and Hobbs, Samantha and Maier, Geraldine and Yurchenco, Peter D. and Rüegg, Markus A.. (2017) Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice. Science Translational Medicine, 9 (396). eaal4649.

Hoffman, E. P.. (2017) Facilitating orphan drug development: Proceedings of the TREAT-NMD International Conference, December 2015, Washington, DC, USA. Neuromuscular Disorders, 27 (7). pp. 693-701.

Kleinert, Maximilian and Parker, Benjamin L. and Fritzen, Andreas M. and Knudsen, Jonas R. and Jensen, Thomas E. and Kjøbsted, Rasmus and Sylow, Lykke and Ruegg, Markus and James, David E. and Richter, Erik A.. (2017) Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. Journal of Physiology, 595 (14). pp. 4845-4855.

Hodson, Nathan and McGlory, Chris and Oikawa, Sara Y. and Jeromson, Stewart and Song, Zhe and Ruegg, Markus A. and Hamilton, D. Lee and Phillips, Stuart M. and Philp, Andrew. (2017) Differential localisation and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise. American Journal of Physiology - Cell Physiology, 313 (6). C604-C611.

Bozadjieva, Nadejda and Blandino-Rosano, Manuel and Chase, Jennifer and Dai, Xiao-Qing and Cummings, Kelsey and Gimeno, Jennifer and Dean, Danielle and Powers, Alvin C. and Gittes, George K. and Rüegg, Markus A. and Hall, Michael N. and MacDonald, Patrick E. and Bernal-Mizrachi, Ernesto. (2017) Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion. The Journal of Clinical Investigation, 127 (12). pp. 4379-4393.

Karakatsani, Andromachi and Marichal, Nicolás and Urban, Severino and Kalamakis, Georgios and Ghanem, Alexander and Schick, Anna and Zhang, Yina and Conzelmann, Karl-Klaus and Rüegg, Markus A. and Berninger, Benedikt and Ruiz de Almodovar, Carmen and Gascón, Sergio and Kröger, Stephan. (2017) Neuronal LRP4 regulates synapse formation in the developing CNS. Development, 144 (24). pp. 4604-4615.

Reinhard, Judith R. and Kriz, Alexander and Galic, Milos and Angliker, Nico and Rajalu, Mathieu and Vogt, Kaspar E. and Rüegg, Markus A.. (2016) The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nature Communications, 7. p. 11613.

Guridi, Maitea and Kupr, Barbara and Romanino, Klaas and Lin, Shuo and Falcetta, Denis and Tintignac, Lionel and Rüegg, Markus A.. (2016) Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism. Skeletal Muscle, 6 (13). pp. 1-14.

Schell, Christoph and Kretz, Oliver and Liang, Wei and Kiefer, Betina and Schneider, Simon and Sellung, Dominik and Bork, Tillmann and Leiber, Christian and Rüegg, Markus A. and Mallidis, Con and Schlatt, Stefan and Mayerhofer, Artur and Huber, Tobias B. and Grahammer, Florian. (2016) The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility. American Journal of Pathology, 186 (2). pp. 324-336.

Ruegsegger, Céline and Stucki, David M. and Steiner, Silvio and Angliker, Nico and Radecke, Julika and Keller, Eva and Zuber, Benoît and Rüegg, Markus A. and Saxena, Smita. (2016) Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology. Neuron, 89 (1). pp. 129-146.

Shende, Pankaj and Xu, Lifen and Morandi, Christian and Pentassuglia, Laura and Heim, Philippe and Lebboukh, Sonia and Berthonneche, Corinne and Pedrazzini, Thierry and Kaufmann, Beat A. and Hall, Michael N. and Rüegg, Markus A. and Brink, Marijke. (2016) Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy. Cardiovascular Research, 109 (1). pp. 103-114.

Kleinert, Maximilian and Parker, Benjamin L. and Chaudhuri, Rima and Fazakerley, Daniel J. and Serup, Annette and Thomas, Kristen C. and Krycer, James R. and Sylow, Lykke and Fritzen, Andreas M. and Hoffman, Nolan J. and Jeppesen, Jacob and Schjerling, Peter and Rüegg, Markus A. and Kiens, Bente and James, David E. and Richter, Erik A.. (2016) mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3. Molecular Metabolism, 5 (8). pp. 646-655.

Ding, Xiaolei and Bloch, Wilhelm and Iden, Sandra and Rüegg, Markus A. and Hall, Michael N. and Leptin, Maria and Partridge, Linda and Eming, Sabine A.. (2016) mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nature Communications, 7. p. 13226.

Castets, Perrine and Frank, Stephan and Sinnreich, Michael and Rüegg, Markus A.. (2016) "Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders. Journal of Neuromuscular Diseases, 3 (2). pp. 127-155.

Aimi, Fabio and Georgiopoulou, Stavroula and Kalus, Ina and Lehner, Fabienne and Hegglin, Alica and Limani, Përparim and Gomes de Lima, Vinicius and Rüegg, Markus A. and Hall, Michael N. and Lindenblatt, Nicole and Haas, Elvira and Battegay, Edouard J. and Humar, Rok. (2015) Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult. Scientific Reports, 5. p. 17705.

Guridi, Maitea and Tintignac, Lionel A. and Lin, Shuo and Kupr, Barbara and Castets, Perrine and Rüegg, Markus A.. (2015) Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21. Science Signaling, 8 (402). ra113.

Angliker, Nico and Burri, Michael and Zaichuk, Mariana and Fritschy, Jean-Marc and Rüegg, Markus A.. (2015) mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. European Journal of Neuroscience, 42 (8). pp. 2595-2612.

Zhang, Yina and Lin, Shuo and Karakatsani, Andromachi and Rüegg, Markus A. and Kröger, Stephan. (2015) Differential regulation of AChR clustering in the polar and equatorial region of murine muscle spindles. European Journal of Neuroscience, 41 (1). pp. 69-78.

Lopez, Rubén J. and Mosca, Barbara and Treves, Susan and Maj, Marcin and Bergamelli, Leda and Calderon, Juan C. and Bentzinger, C. Florian and Romanino, Klaas and Hall, Michael N. and Rüegg, Markus A. and Delbono, Osvaldo and Caputo, Carlo and Zorzato, Francesco. (2015) Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Biochemical Journal, 466 (1). pp. 123-135.

Venkatesh, A. and Ma, S. and Le, Y. Z. and Hall, M. N. and Rüegg, M. A. and Punzo, C.. (2015) Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. Journal of Clinical Investigation, 125 (4). pp. 1446-1458.

Carr, T. D. and Feehan, R. P. and Hall, M. N. and Rüegg, M. A. and Shantz, L. M.. (2015) Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors. Carcinogenesis, 36 (4). pp. 487-497.

Martin, Sally K. and Fitter, Stephen and Dutta, Ankit K. and Matthews, Mary P. and Walkley, Carl R. and Hall, Michael N. and Ruegg, Markus A. and Gronthos, Stan and Zannettino, Andrew C. W.. (2015) Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation. Stem Cells, 33 (4). pp. 1359-1365.

Ma, S. and Venkatesh, A. and Langellotto, F. and Le, Y. Z. and Hall, M. N. and Rüegg, M. A. and Punzo, C.. (2015) Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival. Experimental Eye Research, 135. pp. 1-13.

Tintignac, Lionel A. and Brenner, Hans-Rudolf and Rüegg, Markus A.. (2015) Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting. Physiological Reviews, 95 (3). pp. 809-852.

Domi, Teuta and Porrello, Emanuela and Velardo, Daniele and Capotondo, Alessia and Biffi, Alessandra and Tonlorenzi, Rossana and Amadio, Stefano and Ambrosi, Alessandro and Miyagoe-Suzuki, Yuko and Takeda, Shin'ichi and Ruegg, Markus A. and Previtali, Stefano Carlo. (2015) Mesoangioblast delivery of miniagrin ameliorates murine model of merosin-deficient congenital muscular dystrophy type 1A. Skeletal Muscle, 5 (30). pp. 1-17.

Willmann, Raffaella and De Luca, Annamaria and Nagaraju, Kanneboyina and Rüegg, Markus A.. (2015) Best Practices and Standard Protocols as a Tool to Enhance Translation for Neuromuscular Disorders. Journal of Neuromuscular Diseases, 2 (2). pp. 113-117.

Chen, J. and Tu, X. and Esen, E. and Joeng, K. S. and Lin, C. and Arbeit, J. M. and Rüegg, M. A. and Hall, M. N. and Ma, L. and Long, F.. (2014) WNT7B promotes bone formation in part through mTORC1. PLoS Genetics, 10 (1). e1004145.

Lebrun-Julien, F. and Bachmann, L. and Norrmén, C. and Trötzmüller, M. and Köfeler, H. and Rüegg, M. A. and Hall, M. N. and Suter, U.. (2014) Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination. Journal of Neuroscience, 34 (25). pp. 8432-8448.

Grahammer, F. and Haenisch, N. and Steinhardt, F. and Sander, L. and Roerden, M. and Arnold, F. and Cordts, T. and Wanner, N. and Reichardt, W. and Kerjaschki, D. and Ruegg, M. A. and Hall, M. N. and Moulin, P. and Busch, H. and Boerries, M. and Walz, G. and Artunc, F. and Huber, T. B.. (2014) mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proceedings of the National Academy of Sciences of the United States of America, 111 (27). E2817-E2826.

Zhang, Lianjun and Tschumi, Benjamin O. and Corgnac, Stéphanie and Rüegg, Markus A. and Hall, Michael N. and Mach, Jean-Pierre and Romero, Pedro and Donda, Alena. (2014) Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function. Journal of Immunology, 193 (4). pp. 1759-1765.

Chou, Po-Chien and Oh, Won Jun and Wu, Chang-Chih and Moloughney, Joseph and Rüegg, Markus A. and Hall, Michael N. and Jacinto, Estela and Werlen, Guy. (2014) Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development. Journal of Immunology, 193 (3). pp. 1162-1170.

Norrmén, C. and Figlia, G. and Lebrun-Julien, F. and Pereira, J. A. and Trötzmüller, M. and Köfeler, H. C. and Rantanen, V. and Wessig, C. and van Deijk, A. F. and Smit, A. B. and Verheijen, M. G. and Rüegg, M. A. and Hall, M. N. and Suter, U.. (2014) mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells. Cell Reports , 9 (2). pp. 646-660.

Hettwer, Stefan and Lin, Shuo and Kucsera, Stefan and Haubitz, Monika and Oliveri, Filippo and Fariello, Ruggero G. and Ruegg, Markus A. and Vrijbloed, Jan W.. (2014) Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction. PLoS ONE, 9 (2). e88739.

Miloslavski, Rachel and Cohen, Elad and Avraham, Adam and Iluz, Yifat and Hayouka, Zvi and Kasir, Judith and Mudhasani, Rajini and Jones, Stephen N. and Cybulski, Nadine and Rüegg, Markus A. and Larsson, Ola and Gandin, Valentina and Rajakumar, Arjuna and Topisirovic, Ivan and Meyuhas, Oded. (2014) Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. Journal of Molecular Cell Biology, 6 (3). pp. 255-266.

Kleinert, Maximilian and Sylow, Lykke and Fazakerley, Daniel J. and Krycer, James R. and Thomas, Kristen C. and Oxbøll, Anne-Julie and Jordy, Andreas B. and Jensen, Thomas E. and Yang, Guang and Schjerling, Peter and Kiens, Bente and James, David E. and Ruegg, Markus A. and Richter, Erik A.. (2014) Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo. Molecular Metabolism, 3 (6). pp. 630-641.

Steiner, Esther and Enzmann, Gaby U. and Lyck, Ruth and Lin, Shuo and Rüegg, Markus A. and Kröger, Stephan and Engelhardt, Britta. (2014) The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions. Cell and Tissue Research, 358 (2). pp. 465-479.

Bentzinger, C. Florian and Lin, Shuo and Romanino, Klaas and Castets, Perrine and Guridi, Maitea and Summermatter, Serge and Handschin, Christoph and Tintignac, Lionel A. and Hall, Michael N. and Rüegg, Markus A.. (2013) Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal Muscle, 3 (1). p. 6.

Thomanetz, Venus and Angliker, Nico and Cloëtta, Dimitri and Lustenberger, Regula M. and Schweighauser, Manuel and Oliveri, Filippo and Suzuki, Noboru and Rüegg, Markus A.. (2013) Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology. The journal of cell biology, Vol. 201, H. 2. pp. 293-308.

Cloëtta, Dimitri and Thomanetz, Venus and Baranek, Constanze and Lustenberger, Regula M. and Lin, Shuo and Oliveri, Filippo and Atanasoski, Suzana and Rüegg, Markus A.. (2013) Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis. Journal of neuroscience, Vol. 33, H. 18. pp. 7799-7810.

Castets, Perrine and Lin, Shuo and Rion, Nathalie and Di Fulvio, Sabrina and Romanino, Klaas and Guridi, Maitea and Frank, Stephan and Tintignac, Lionel A. and Sinnreich, Michael and Ruegg, Markus A.. (2013) Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy. Cell metabolism, 17 (5). pp. 731-744.

Song, Jian and Lokmic, Zerina and Lämmermann, Tim and Rolf, Julia and Wu, Chuan and Zhang, Xueli and Hallmann, Rupert and Hannocks, Melanie-Jane and Horn, Nathalie and Ruegg, Markus A. and Sonnenberg, Arnoud and Georges-Labouesse, Elisabeth and Winkler, Thomas H. and Kearney, John F. and Cardell, Susanna and Sorokin, Lydia. (2013) Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proceedings of the National Academy of Sciences of the United States of America, 110 (31). pp. 2915-E2924.

Castets, Perrine and Rüegg, Markus A.. (2013) MTORC1 determines autophagy through ULK1 regulation in skeletal muscle. Autophagy, 9 (9). pp. 1435-1437.

Angliker, Nico and Rüegg, Markus A.. (2013) In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons. Bioarchitecture, 3 (4). pp. 113-118.

Hagiwara, Asami and Cornu, Marion and Cybulski, Nadine and Polak, Pazit and Betz, Charles and Trapani, Francesca and Terracciano, Luigi and Heim, Markus H. and Rüegg, Markus A. and Hall, Michael N.. (2012) Hepatic mTORC2 activates glycolysis and lipogenesis through akt, glucokinase, and SREBP1c. Cell Metabolism, 15 (5). pp. 725-738.

Punga, Anna Rostedt and Ruegg, Markus A.. (2012) Signaling and aging at the neuromuscular synapse : lessons learnt from neuromuscular diseases. Current Opinion in Pharmacology, 12 (3). pp. 340-346.

Blättler, Sharon M. and Cunningham, John T. and Verdeguer, Francisco and Chim, Helen and Haas, Wilhelm and Liu, Huifei and Romanino, Klaas and Rüegg, Markus A. and Gygi, Steven P. and Shi, Yang and Puigserver, Pere. (2012) Yin yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metabolism, 15 (4). pp. 505-517.

Meinen, Sarina and Lin, Shuo and Rüegg, Markus A. and Punga, Anna Rostedt. (2012) Fatigue and Muscle Atrophy in a Mouse Model of Myasthenia Gravis Is Paralleled by Loss of Sarcolemmal nNOS. PLoS ONE, Vol. 7, H. 8 , e44148.

Blättler, Sharon M. and Verdeguer, Francisco and Liesa, Marc and Cunningham, John T. and Vogel, Rutger O. and Chim, Helen and Liu, Huifei and Romanino, Klaas and Shirihai, Orian S. and Vazquez, Francisca and Rüegg, Markus A. and Shi, Yang and Puigserver, Pere. (2012) Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Molecular and cellular biology, 32 (16). pp. 3333-3346.

Meinen, Sarina and Lin, Shuo and Ruegg, Markus A.. (2012) Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A). Skeletal muscle, Vol. 2, H. 1. p. 18.

Steiner, Esther and Enzmann, Gaby U. and Lin, Shuo and Ghavampour, Sharang and Hannocks, Melanie-Jane and Zuber, Benoît and Rüegg, Markus A. and Sorokin, Lydia and Engelhardt, Britta. (2012) Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. Glia, 60 (11). pp. 1646-1659.

Inoki, K. and Mori, H. and Wang, J. and Suzuki, T. and Hong, S. and Yoshida, S. and Blattner, S. M. and Ikenoue, T. and Ruegg, M. A. and Hall, M. N. and Kwiatkowski, D. J. and Rastaldi, M. P. and Huber, T. B. and Kretzler, M. and Holzman, L. B. and Wiggins, R. C. and Guan, K. -L.. (2011) mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. Journal of Clinical Investigation, 121 (6). pp. 2181-2196.

Godel, M. and Hartleben, B. and Herbach, N. and Liu, S. and Zschiedrich, S. and Lu, S. and Debreczeni-Mor, A. and Lindenmeyer, M. T. and Rastaldi, M. -P. and Hartleben, G. and Wiech, T. and Fornoni, A. and Nelson, R. G. and Kretzler, M. and Wanke, R. and Pavenstadt, H. and Kerjaschki, D. and Cohen, C. D. and Hall, M. N. and Ruegg, M. A. and Inoki, K. and Walz, G. and Huber, T. B.. (2011) Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. Journal of Clinical Investigation, 121 (6). pp. 2197-2209.

Shende, P. and Plaisance, I. and Morandi, C. and Pellieux, C. and Berthonneche, C. and Zorzato, F. and Krishnan, J. and Lerch, R. and Hall, M. N. and Ruegg, M. A. and Pedrazzini, T. and Brink, M.. (2011) Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. Circulation, 123 (10). pp. 1073-1082.

Punga, A. R. and Lin, S. and Oliveri, F. and Meinen, S. and Ruegg, M. A.. (2011) Muscle-selective synaptic disassembly and reorganization in MuSK antibody positive MG mice. Experimental Neurology, 230 (2). pp. 207-217.

Punga, A. R. and Maj, M. and Lin, S. and Meinen, S. and Ruegg, M. A.. (2011) MuSK levels differ between adult skeletal muscles and influence postsynaptic plasticity. The European journal of neuroscience, Vol. 33, H. 5. pp. 890-898.

Meinen, Sarina and Lin, Shuo and Thurnherr, Raphael and Erb, Michael and Meier, Thomas and Rüegg, Markus A.. (2011) Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO Molecular Medicine, 3 (8). pp. 465-479.

Rieker, Claus and Dev, Kumlesh K. and Lehnhoff, Katja and Barbieri, Samuel and Ksiazek, Iwona and Kauffmann, Sabine and Danner, Simone and Schell, Heinrich and Boden, Cindy and Ruegg, Markus A. and Kahle, Philipp J. and van der Putten, Herman and Shimshek, Derya R.. (2011) Neuropathology in mice expressing mouse alpha-synuclein. PLoS ONE, Vol. 6, H. 9 , e24834.

Romanino, Klaas and Mazelin, Laetitia and Albert, Verena and Conjard-Duplany, Agnès and Lin, Shuo and Bentzinger, C. Florian and Handschin, Christoph and Puigserver, Pere and Zorzato, Francesco and Schaeffer, Laurent and Gangloff, Yann-Gaël and Rüegg, Markus A.. (2011) Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 51. pp. 20808-20813.

Rüegg, Markus A. and Glass, David J.. (2010) Molecular mechanisms and treatment options for muscle wasting eiseases. Annual Review of Pharmacology and Toxicology, 51. pp. 373-395.

Escher, Claudia and Lochmüller, Hanns and Fischer, Dirk and Frank, Stephan and Reimann, Jens and Walter, Maggie C. and Ehrat, Markus and Ruegg, Markus A. and Gygax, Daniel. (2010) Reverse protein arrays as novel approach for protein quantification in muscular dystrophies. Neuromuscular disorders, 20. pp. 302-309.

Cybulski, N. and Polak, P. and Auwerx, J. and Ruegg, M. A. and Hall, M. N.. (2009) mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proceedings of the National Academy of Sciences of the United States of America, 106 (24). pp. 9902-9907.

Patursky-Polischuk, I. and Stolovich-Rain, M. and Hausner-Hanochi, M. and Kasir, J. and Cybulski, N. and Avruch, J. and Ruegg, M. A. and Hall, M. N. and Meyuhas, O.. (2009) The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Molecular and cellular biology, Vol. 29, H. 3. pp. 640-649.

Huze, C. and Bauche, S. and Richard, P. and Chevessier, F. and Goillot, E. and Gaudon, K. and Ben Ammar, A. and Chaboud, A. and Grosjean, I. and Lecuyer, H. -A. and Bernard, V. and Rouche, A. and Alexandri, N. and Kuntzer, T. and Fardeau, M. and Fournier, E. and Brancaccio, A. and Ruegg, M. A. and Koenig, J. and Eymard, B. and Schaeffer, L. and Hantai, D.. (2009) Identification of an agrin mutation that causes congenital myasthenia and affects synapse function. American Journal of Human Genetics, 85 (2). pp. 155-167.

Erb, M. and Meinen, S. and Barzaghi, P. and Sumanovski, L. T. and Courdier-Fruh, I. and Ruegg, M. A. and Meier, T.. (2009) Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-α2 deficiency. Journal of pharmacology and experimental therapeutics, 331 (3). pp. 787-795.

Willmann, Raffaella and Possekel, Stefanie and Dubach-Powell, Judith and Meier, Thomas and Rüegg, Markus A.. (2009) Mammalian animal models for Duchenne muscular dystrophy. Neuromuscular Disorders, 19 (4). pp. 241-249.

Risson, Valérie and Mazelin, Laetitia and Roceri, Mila and Sanchez, Hervé and Moncollin, Vincent and Corneloup, Claudine and Richard-Bulteau, Hélène and Vignaud, Alban and Baas, Dominique and Defour, Aurélia and Freyssenet, Damien and Tanti, Jean-François and Le-Marchand-Brustel, Yannick and Ferrier, Bernard and Conjard-Duplany, Agnès and Romanino, Klaas and Bauché, Stéphanie and Hantaï, Daniel and Mueller, Matthias and Kozma, Sara C. and Thomas, George and Rüegg, Markus A. and Ferry, Arnaud and Pende, Mario and Bigard, Xavier and Koulmann, Nathalie and Schaeffer, Laurent and Gangloff, Yann-Gaël. (2009) Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. The Journal of cell biology, Vol. 187, H. 6. pp. 859-874.

Reiterer, V. and Maier, S. and Sitte, H. H. and Kriz, A. and Ruegg, M. A. and Hauri, H. P. and Freissmuth, M. and Farhan, H.. (2008) Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting. Journal of Neuroscience, 28 (47). pp. 12453-12464.

Lin, S. and Maj, M. and Bezakova, G. and Magyar, J. P. and Brenner, H. R. and Ruegg, M. A.. (2008) Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice. Proceedings of the National Academy of Sciences of the United States of America, 105 (32). pp. 11406-11411.

Lin, S. and Landmann, L. and Ruegg, M. A. and Brenner, H. R.. (2008) The role of nerve- versus muscle-derived factors in mammalian neuromuscular junction formation. Journal of neuroscience, Vol. 28, H. 13. pp. 3333-3340.

Polak, P. and Cybulski, N. and Feige, J. N. and Auwerx, J. and Ruegg, M. A. and Hall, M. N.. (2008) Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration. Cell Metabolism, Vol. 8, H. 5. pp. 399-410.

Bentzinger, C. F. and Romanino, K. and Cloetta, D. and Lin, S. and Mascarenhas, J. B. and Oliveri, F. and Xia, J. and Casanova, E. and Costa, C. F. and Brink, M. and Zorzato, F. and Hall, M. N. and Ruegg, M. A.. (2008) Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metabolism, 8 (5). pp. 411-424.

Hausser, Heinz-Juergen and Ruegg, Markus A. and Brenner, Rolf E. and Ksiazek, Iwona. (2007) Agrin is highly expressed by chondrocytes and is required for normal growth. Histochemistry and Cell Biology, 127 (4). pp. 363-374.

Plachta, N. and Annaheim, C. and Bissiere, S. and Lin, S. and Ruegg, M. and Hoving, S. and Muller, D. and Poirier, F. and Bibel, M. and Barde, Y. -A.. (2007) Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells. Nature neuroscience, Vol. 10, H. 6. pp. 712-719.

Meinen, S. and Barzaghi, P. and Lin, S. and Lochmuller, H. and Ruegg, M. A.. (2007) Linker molecules between laminins and dystroglycan ameliorate laminin-alpha2-deficient muscular dystrophy at all disease stages. The Journal of cell biology, Vol. 176, H. 7. pp. 979-993.

Ksiazek, Iwona and Burkhardt, Constanze and Lin, Shuo and Seddik, Riad and Maj, Marcin and Bezakova, Gabriela and Jucker, Mathias and Arber, Silvia and Caroni, Pico and Sanes, Joshua R. and Bettler, Bernhard and Ruegg, Markus A.. (2007) Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death. Journal of Neuroscience, 27 (27). pp. 7183-7195.

Camilleri, A. A. and Willmann, R. and Sadasivam, G. and Lin, S. and Ruegg, M. A. and Gesemann, M. and Fuhrer, C.. (2007) Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors. BMC Neuroscience, 8 (46). pp. 1-16.

Annies, M. and Bittcher, G. and Ramseger, R. and Loschinger, J. and Woll, S. and Porten, E. and Abraham, C. and Ruegg, M. A. and Kroger, S.. (2006) Clustering transmembrane-agrin induces filopodia-like processes on axons and dendrites. Molecular and cellular neuroscience, Vol. 31, H. 3. pp. 515-524.

Jokic, N. and Gonzalez de Aguilar, J. -L. and Dimou, L. and Lin, S. and Fergani, A. and Ruegg, M. A. and Schwab, M. E. and Dupuis, L. and Loeffler, J. -P.. (2006) The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model. EMBO reports, Vol. 7, H. 11. pp. 1162-1167.

Scotton, P. and Bleckmann, D. and Stebler, M. and Sciandra, F. and Brancaccio, A. and Meier, T. and Stetefeld, J. and Ruegg, M. A.. (2006) Activation of muscle-specific receptor tyrosine kinase and binding to dystroglycan are regulated by alternative mRNA splicing of agrin. Journal of Biological Chemistry, 281 (48). pp. 36835-36845.

Meinen, S. and Ruegg, M. A.. (2006) Congenital muscular dystrophy: mini-agrin delivers in mice. Gene Therapy, Vol. 13, H. 11. pp. 869-870.

Possekel, S. and Meier, T. and Ruegg, M. A.. (2006) Peripheral signaling pathways involved in muscle loss. In: Pharmacotherapy of Cachexia. Boca Raton, FL, USA, pp. 543-564.

Ruegg, M. A.. (2006) Commonalities and differences in muscular dystrophies : mechanisms and molecules involved in merosin-deficient congenital muscular dystrophy. In: Molecular mechanisms of muscular dystrophies. Georgetown, Tex., pp. 74-81.

Madhavan, R. and Zhao, X. T. and Ruegg, M. A. and Peng, H. B.. (2005) Tyrosine phosphatase regulation of MuSK-dependent acetylcholine receptor clustering. Molecular and cellular neuroscience, Vol. 28, H. 3. pp. 403-416.

Sadasivam, G. and Willmann, R. and Lin, S. and Erb-Vogtli, S. and Kong, X. C. and Ruegg, M. A. and Fuhrer, C.. (2005) Src-family kinases stabilize the neuromuscular synapse in vivo via protein interactions, phosphorylation, and cytoskeletal linkage of acetylcholine receptors. Journal of Neuroscience, 25 (45). pp. 10479-10493.

Smirnov, S. P. and Barzaghi, P. and McKee, K. K. and Ruegg, M. A. and Yurchenco, P. D.. (2005) Conjugation of LG domains of agrins and perlecan to polymerizing laminin-2 promotes acetylcholine receptor clustering. Journal of Biological Chemistry, 280 (50). pp. 41449-41457.

Ruegg, M. A.. (2005) Organization of synaptic myonuclei by Syne proteins and their role during the formation of the nerve-muscle synapse. Proceedings of the National Academy of Sciences of the United States of America, 102 (16). pp. 5643-5644.

Mascarenhas, J. B. and Ruegg, M. A. and Sasaki, T. and Eble, J. A. and Engel, J. and Stetefeld, J.. (2005) Structure and laminin-binding specificity of the NtA domain expressed in eukaryotic cells. Matrix Biology, Vol. 23, H. 8. pp. 507-513.

Bentzinger, C. F. and Barzaghi, P. and Lin, S. and Ruegg, M. A.. (2005) Overexpression of mini-agrin in skeletal muscle increases muscle integrity and regenerative capacity in laminin-alpha2-deficient mice. FASEB Journal, 19 (8). pp. 934-942.

Stetefeld, J. and Ruegg, M. A.. (2005) Structural and functional diversity generated by alternative mRNA splicing. Trends in biochemical sciences, Vol. 30, H. 9. pp. 515-521.

Jacinto, E. and Loewith, R. and Schmidt, A. and Lin, S. and Ruegg, M. A. and Hall, A. and Hall, M. N.. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nature Cell Biology, Vol. 6, H. 11. pp. 1122-1128.

Kong, X. C. and Barzaghi, P. and Ruegg, M. A.. (2004) Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference. EMBO reports, Vol. 5, H. 2. pp. 183-188.

Ruegg, M. A. and McMahan, U. J.. (2004) Agrin. In: Encyclopedia of Neuroscience. Amsterdam.

Stetefeld, J. and Alexandrescu, A. T. and Maciejewski, M. W. and Jenny, M. and Rathgeb-Szabo, K. and Schulthess, T. and Landwehr, R. and Frank, S. and Ruegg, M. A. and Kammerer, R. A.. (2004) Modulation of agrin function by alternative splicing and Ca2+ binding. Structure: with folding and design, Vol. 12, H. 3. pp. 503-515.

Bezakova, G. and Ruegg, M. A.. (2003) New insights into the roles of agrin. Nature reviews. Molecular cell biology, Vol. 4, H. 4. pp. 295-308.

Mascarenhas, J. B. and Ruegg, M. A. and Winzen, U. and Halfter, W. and Engel, J. and Stetefeld, J.. (2003) Mapping of the laminin-binding site of the N-terminal agrin domain (NtA). The EMBO Journal, 22 (3). pp. 529-536.

Bartoccioni, E. and Marino, M. and Evoli, A. and Ruegg, M. A. and Scuderi, F. and Provenzano, C.. (2003) Identification of disease-specific autoantibodies in seronegative myasthenia gravis. Annals of the New York Academy of Sciences, 998. pp. 356-358.

Guo, L. T. and Zhang, X. U. and Kuang, W. and Xu, H. and Liu, L. A. and Vilquin, J. -T. and Miyagoe-Suzuki, Y. and Takeda, S. and Ruegg, M. A. and Wewer, U. M. and Engvall, E.. (2003) Laminin alpha2 deficiency and muscular dystrophy : genotype-phenotype correlation in mutant mice. Neuromuscular Disorders, Vol. 13, H. 3. pp. 207-215.

Eusebio, A. and Oliveri, F. and Barzaghi, P. and Ruegg, M. A.. (2003) Expression of mouse agrin in normal, denervated and dystrophic muscle. Neuromuscular Disorders, Vol. 13, H. 5. pp. 408-415.

Abicht, A. and Stucka, R. and Schmidt, C. and Briguet, A. and Hopfner, S. and Song, I. -H. and Pongratz, D. and Muller-Felber, W. and Ruegg, M. A. and Lochmuller, H.. (2002) A newly identified chromosomal microdeletion and an N-box mutation of the AChR epsilon gene cause a congenital myasthenic syndrome. Brain, 125 (5). pp. 1005-1013.

Bixby, J. L. and Baerwald-De la Torre, K. and Wang, C. and Rathjen, F. G. and Ruegg, M. A.. (2002) A neuronal inhibitory domain in the N-terminal half of agrin. Journal of Neurobiology, 50 (2). pp. 164-179.

Pun, S. and Sigrist, M. and Santos, A. F. and Ruegg, M. A. and Sanes, J. R. and Jessell, T. M. and Arber, S. and Caroni, P.. (2002) An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles. Neuron, Vol. 34, H. 3. pp. 357-370.

Moll, J. and Barzaghi, P. and Lin, S. and Bezakova, G. and Lochmuller, H. and Engvall, E. and Muller, U. and Ruegg, M. A.. (2001) An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy. Nature, 413 (6853). pp. 302-307.

Stetefeld, J. and Jenny, M. and Schulthess, T. and Landwehr, R. and Schumacher, B. and Frank, S. and Ruegg, M. A. and Engel, J. and Kammerer, R. A.. (2001) The laminin-binding domain of agrin is structurally related to N-TIMP-1. Nature Structural biology, Vol. 8, H. 8. pp. 705-709.

Neumann, Frank R. and Bittcher, Godela and Annies, Maik and Schumacher, Beat and Kroger, Stephan and Ruegg, Markus A.. (2001) An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein. Molecular and cellular neuroscience, 17 (1). pp. 208-225.

Alexandrescu, A. T. and Maciejewski, M. W. and Ruegg, M. A. and Engel, J. and Kammerer, R. A.. (2001) 1H, 13C and 15N backbone assignments for the C-terminal globular domain of agrin. Journal of Biomolecular NMR, 20 (3). pp. 295-296.

Ruegg, M. A.. (2001) Molecules involved in the formation of synaptic connections in muscle and brain. Matrix Biology, Vol. 20, H. 1. pp. 3-12.

Halfter, W. and Dong, S. and Schurer, B. and Osanger, A. and Schneider, W. and Ruegg, M. and Cole, G. J.. (2000) Composition, synthesis, and assembly of the embryonic chick retinal basal lamina. Developmental biology, Vol. 220, H. 2. pp. 111-128.

van der Putten, H. and Wiederhold, K. H. and Probst, A. and Barbieri, S. and Mistl, C. and Danner, S. and Kauffmann, S. and Hofele, K. and Spooren, W. P. and Ruegg, M. A. and Lin, S. and Caroni, P. and Sommer, B. and Tolnay, M. and Bilbe, G.. (2000) Neuropathology in mice expressing human alpha-synuclein. Journal of Neuroscience, 20 (16). pp. 6021-6029.

Meier, T. and Ruegg, M. A.. (2000) The Role of Dystroglycan and Its Ligands in Physiology and Disease. News in physiological sciences, Vol. 15. pp. 255-259.

Briguet, A. and Ruegg, M. A.. (2000) The Ets transcription factor GABP is required for postsynaptic differentiation in vivo. Journal of neuroscience, Vol. 20, H. 16. pp. 5989-5996.

Sommer, B. and Barbieri, S. and Hofele, K. and Wiederhold, K. and Probst, A. and Mistl, C. and Danner, S. and Kauffmann, S. and Spooren, W. and Tolnay, M. and Bilbe, G. and Kafmann, S. and Caromi, P. and Ruegg, M. A.. (2000) Mouse models of alpha-synucleinopathy and Lewy pathology. Experimental gerontology, Vol. 35, no. 9-10. pp. 1389-1403.

Kammerer, R. A. and Schulthess, T. and Landwehr, R. and Schumacher, B. and Lustig, A. and Yurchenco, P. D. and Ruegg, M. A. and Engel, J. and Denzer, A. J.. (1999) Interaction of agrin with laminin requires a coiled-coil conformation of the agrin-binding site within the laminin gamma1 chain. The EMBO Journal, 18 (23). pp. 6762-6770.

Meier, T. and Marangi, P. A. and Moll, J. and Hauser, D. M. and Brenner, H. R. and Ruegg, M. A.. (1998) A minigene of neural agrin encoding the laminin-binding and acetylcholine receptor-aggregating domains is sufficient to induce postsynaptic differentiation in muscle fibres. The European journal of neuroscience, Vol. 10, H. 10. pp. 3141-3152.

Meier, T. and Ruegg, M. A. and Wallace, B. G.. (1998) Muscle-specific agrin isoforms reduce phosphorylation of AChR gamma and delta subunits in cultured muscle cells. Molecular and cellular neuroscience, Vol. 11, H. 4. pp. 206-216.

Nawrotzki, R. and Loh, N. Y. and Ruegg, M. A. and Davies, K. E. and Blake, D. J.. (1998) Characterisation of alpha-dystrobrevin in muscle. Journal of Cell Science, 111 (17). pp. 2595-2605.

Gesemann, M. and Brancaccio, A. and Schumacher, B. and Ruegg, M. A.. (1998) Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue. Journal of Biological Chemistry, 273 (1). pp. 600-605.

Sieb, J. P. and Dorfler, P. and Tzartos, S. and Wewer, U. M. and Ruegg, M. A. and Meyer, D. and Baumann, I. and Lindemuth, R. and Jakschik, J. and Ries, F.. (1998) Congenital myasthenic syndromes in two kinships with end-plate acetylcholine receptor and utrophin deficiency. Neurology, 50 (1). pp. 54-61.

Denzer, A. J. and Schulthess, T. and Fauser, C. and Schumacher, B. and Kammerer, R. A. and Engel, J. and Ruegg, M. A.. (1998) Electron microscopic structure of agrin and mapping of its binding site in laminin-1. The EMBO Journal, 17 (2). pp. 335-343.

Ruegg, M. A. and Bixby, J. L.. (1998) Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction. Trends in Neurosciences, 21 (1). pp. 22-27.

Groffen, A. J. and Ruegg, M. A. and Dijkman, H. and van de Velden, T. J. and Buskens, C. A. and van den Born, J. and Assmann, K. J. and Monnens, L. A. and Veerkamp, J. H. and van den Heuvel, L. P.. (1998) Agrin is a major heparan sulfate proteoglycan in the human glomerular basement membrane. Journal of Histochemistry and Cytochemistry, 46 (1). pp. 19-27.

Campagna, J. A. and Ruegg, M. A. and Bixby, J. L.. (1997) Evidence that agrin directly influences presynaptic differentiation at neuromuscular junctions in vitro. The European journal of neuroscience, Vol. 9, H. 11. pp. 2269-2283.

Meier, T. and Hauser, D. M. and Chiquet, M. and Landmann, L. and Ruegg, M. A. and Brenner, H. R.. (1997) Neural agrin induces ectopic postsynaptic specializations in innervated muscle fibers. Journal of neuroscience, 17 (17). pp. 6534-6544.

Denzer, A. J. and Hauser, D. M. and Gesemann, M. and Ruegg, M. A.. (1997) Synaptic differentiation : the role of agrin in the formation and maintenance of the neuromuscular junction. Cell and Tissue Research, 290 (2). pp. 357-365.

Denzer, A. J. and Brandenberger, R. and Gesemann, M. and Chiquet, M. and Ruegg, M. A.. (1997) Agrin binds to the nerve-muscle basal lamina via laminin. The Journal of cell biology, Vol. 137, H. 3. pp. 671-683.

Gesemann, M. and Cavalli, V. and Denzer, A. J. and Brancaccio, A. and Schumacher, B. and Ruegg, M. A.. (1996) Alternative splicing of agrin alters its binding to heparin, dystroglycan, and the putative agrin receptor. Neuron, Vol. 16, H. 4. pp. 755-767.

Jones, G. and Herczeg, A. and Ruegg, M. A. and Lichtsteiner, M. and Kroger, S. and Brenner, H. R.. (1996) Substrate-bound agrin induces expression of acetylcholine receptor epsilon-subunit gene in cultured mammalian muscle cells. Proceedings of the National Academy of Sciences of the United States of America, 93 (12). pp. 5985-5990.

Yamada, H. and Denzer, A. J. and Hori, H. and Tanaka, T. and Anderson, L. V. and Fujita, S. and Fukuta-Ohi, H. and Shimizu, T. and Ruegg, M. A. and Matsumura, K.. (1996) Dystroglycan is a dual receptor for agrin and laminin-2 in Schwann cell membrane. Journal of Biological Chemistry, 271 (38). pp. 23418-23423.

Ruegg, M. A.. (1996) Agrin, laminin beta 2 (s-laminin) and ARIA : their role in neuromuscular development. Current Opinion in Neurobiology, Vol. 6, H. 1. pp. 97-103.

Meier, T. and Gesemann, M. and Cavalli, V. and Ruegg, M. A. and Wallace, B. G.. (1996) AChR phosphorylation and aggregation induced by an agrin fragment that lacks the binding domain for alpha-dystroglycan. The EMBO Journal, 15 (11). pp. 2625-2631.

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