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Items where contributor is "Pieters, Jean"

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2015

BoseDasgupta, Somdeb and Moes, Suzette and Jenoe, Paul and Pieters, Jean. (2015) Cytokine-Induced Macropinocytosis in Macrophages is regulated by 14-3-3ζ through its Interaction with Serine-Phosphorylated Coronin 1. The FEBS journal, Vol. 282, H. 7. S. 1167-1181.

Jayachandran, Rajesh and Pieters, Jean. (2015) Regulation of immune cell homeostasis and function by coronin 1. International immunopharmacology, Vol. 28, no. 2. S. 825-828.

2014

van der Woude, A. D. and Stoop, E. J. and Stiess, M. and Wang, S. and Ummels, R. and van Stempvoort, G. and Piersma, S. R. and Cascioferro, A. and Jiménez, C. R. and Houben, E. N. and Luirink, J. and Pieters, J. and van der Sar, A. M. and Bitter, W.. (2014) Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector. Cellular microbiology, Vol. 16, H. 2 , S. 280–295.

Lima, W. C. and Vinet, A. and Pieters, J. and Cosson, P.. (2014) Role of PKD2 in Rheotaxis in Dictyostelium. PLoS one, Vol. 9, H. 2. S. 1-9.

Vinet, A. and Fieder, T. and Froquet, R. and Dardel, A. and Cosson, P. and Pieters, J.. (2014) Initiation of multicellular differentation in Dictyostelium discoideum regulated by coronin A. Molecular biology of the cell, Vol. 25, H. 5. S. 688-701.

Jayachandran, R. and Liu, X. and Bosedasgupta, S. and Müller, P. and Zhang, C. and Moshous, D. and Studer, V. and Schneider, J. and Genoud, C. and Fossoud, C. and Gambino, F. and Khelfaoui, M. and Müller, C. and Bartholdi, D. and Rossez, H. and Stiess, M. and Houbaert, X. and Jaussi, R. and Frey, D. and Kammerer, R. A. and Deupi, X. and de Villartay, J.-P. and Lüthi, A. and Humeau, Y. and Pieters, J.. (2014) Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling. PLoS Biology, Vol. 12, H. 3 , e1001820. S. 1-21.

Bosedasgupta, S. and Pieters, J.. (2014) Inflammatory Stimuli Reprogram Macrophage Phagocytosis to Macropinocytosis for the Rapid Elimination of Pathogens. PLoS pathogens, Vol. 10, H. 1. S. 1-18.

von Burg, Nicole and Chappaz, Stéphane and Baerenwaldt, Anne and Horvath, Edit and Bose Dasgupta, Somdeb and Ashok, Devika and Pieters, Jean and Tacchini-Cottier, Fabienne and Rolink, Antonius and Acha-Orbea, Hans and Finke, Daniela. (2014) Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses. Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, H. 35. S. 12835-12840.

BoseDasgupta, Somdeb and Pieters, Jean. (2014) Coronin 1 trimerization is essential to protect pathogenic mycobacteria within macrophages from lysosomal delivery. FEBS letters, Vol. 588, H. 21. S. 3898-3905.

BoseDasgupta, Somdeb and Pieters, Jean. (2014) Striking the Right Balance Determines TB or Not TB. Frontiers in immunology, Vol. 5. S. 455.

BoseDasgupta Somdeb, Pieters Jean. (2014) How to clear a pathogen during inflammation: switching from phagocytosis to macropinocytosis through coronin 1 phosphorylation. Inflammation and cell signaling, Vol. 1, Nr. 4 , e199.

Gruber, Andreas R. and Martin, Georges and Müller, Philipp and Schmidt, Alexander and Gruber, Andreas J. and Gumienny, Rafal and Mittal, Nitish and Jayachandran, Rajesh and Pieters, Jean and Keller, Walter. (2014) Global 3' UTR shortening has a limited effect on protein abundance in proliferating T cells. Nature communications, 5 (5465).

2013

Tchang, Vincent Sam Yong and Mekker, Andrea and Siegmund, Kerstin and Karrer, Urs and Pieters, Jean. (2013) Diverging role for coronin 1 in antiviral CD4(+) and CD8(+) T cell responses. Molecular immunology, Vol. 56, H. 4. S. 683-692.

Siegmund, Kerstin and Lee, Woo-Yong and Tchang, Vincent S. and Stiess, Michael and Terracciano, Luigi and Kubes, Paul and Pieters, Jean. (2013) Coronin 1 is dispensable for leukocyte recruitment and liver injury in concanavalin A-induced hepatitis. Immunology letters, Vol. 153, No. 1-2. S. 62-70.

Pieters, Jean and Müller, Philipp and Jayachandran, Rajesh. (2013) On guard: coronin proteins in innate and adaptive immunity. Nature reviews. Immunology, Vol. 13, H. 7. S. 510-518.

Pieters, Jean and McKinney, John. (2013) Preface to Pathogenesis of Mycobacterium tuberculosis and its interaction with the host organism. Current topics in microbiology and immunology, Vol. 374 , S. V-VI.

2012

Jayachandran, Rajesh and Scherr, Nicole and Pieters, Jean. (2012) Elimination of intracellularly residing Mycobacterium tuberculosis through targeting of host and bacterial signaling mechanisms. Expert review of anti-infective therapy, Vol. 10, H. 9. S. 1007-1022.

Westritschnig, K. and Bosedasgupta, S. and Tchang, V. and Siegmund, K. and Pieters, J.. (2012) Antigen processing and presentation by dendritic cells is independent of coronin 1. Molecular immunology, Vol. 53, H. 4. S. 379-386.

Janssen, S. and Jayachandran, R. and Khathi, L. and Zinsstag, J. and Grobusch, M. P. and Pieters, J.. (2012) Exploring prospects of novel drugs for tuberculosis. Drug design, development and therapy, Vol. 6. S. 217-224.

Jayachandran, R. and Bosedasgupta, S. and Pieters, J.. (2012) Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis. Current topics in microbiology and immunology, Vol. 374. S. 189-209.

2011

Mueller, Philipp and Liu, Xiaolong and Pieters, Jean. (2011) Migration and homeostasis of naive T cells depends on coronin 1-mediated prosurvival signals and not on coronin 1-dependent filamentous actin modulation. Journal of Immunology, 186 (7). pp. 4039-4050.

2010

Mueller, P. and Scherr, N. and Jayachandran, R. and Pieters, J.. (2010) Subversion of host immune responses by Macobacterium tuberculosis. In: Host-pathogen interactions. New York, S. 145-152.

Cheng, Yong and Pieters, Jean. (2010) Novel proteasome inhibitors as potential drugs to combat tuberculosis. Journal of Molecular Cell Biology, 2 (4). pp. 173-175.

2009

Bottova, I. and Hehl, A. B. and Stefanic, S. and Fabrias, G. and Casas, J. and Schraner, E. and Pieters, J. and Sonda, S.. (2009) Host cell P-glycoprotein is essential for cholesterol uptake and replication of Toxoplasma gondii. Journal of biological chemistry, Vol. 284, H. 26. S. 17438-17448.

Combaluzier, Benoit and Mueller, Philipp and Massner, Jan and Finke, Daniela and Pieters, Jean. (2009) Coronin 1 is essential for IgM-mediated Ca2+ mobilization in B cells but dispensable for the generation of immune responses in vivo. Journal of immunology, Vol. 182, H. 4. S. 1954-1961.

Combaluzier, B. and Pieters, J.. (2009) Chemotaxis and phagocytosis in neutrophils is independent of coronin 1. Journal of immunology, Vol. 182, H. 5. S. 2745-2752.

Scherr, N. and Muller, P. and Perisa, D. and Combaluzier, B. and Jenö, P. and Pieters, J.. (2009) Survival of pathogenic mycobacteria in macrophages is mediated through autophosphorylation of protein kinase G. Journal of bacteriology, 191 (14). pp. 4546-4554.

Houben, E. N. G. and Walburger, A. and Ferrari, G. and Nguyen, L. and Thompson, C. J. and Miess, C. and Vogel, G. and Mueller, B. and Pieters, J.. (2009) Differential expression of a virulence factor in pathogenic and non-pathogenic mycobacteria. Molecular microbiology, Vol. 72, H. 1. S. 41-52.

Nguyen, L. and Pieters, J.. (2009) Mycobacterial subversion of chemotherapeutic reagents and host defense tactics : challenges in tuberculosis drug development. Annual review of pharmacology and toxicology, Vol. 49. S. 427-453.

Scherr, N. and Jayachandran, R. and Mueller, P. and Pieters, J.. (2009) Interference of Mycobacterium tuberculosis with macrophage responses. Indian Journal of Experimental Biology, Vol. 47, H. 6. S. 401-406.

Scherr, N. and Pieters, J.. (2009) The Eukaryotic-like Serine/Threonine Kinase Family in Mycobacteria. In: Mycobacterium. Norfolk, S. 171-192.

Jayachandran, R. and Scherr, N. and Pieters, J.. (2009) Analyzing the interaction of pathogens with the host immune system. Immunology letters, Vol. 122, No. 2. S. 112-114.

2008

Jayachandran, R. and Gatfield, J. and Massner, J. and Albrecht, I. and Zanolari, B. and Pieters, J.. (2008) RNA interference in J774 macrophages reveals a role for coronin 1 in mycobacterial trafficking but not in actin-dependent processes. Molecular biology of the cell, Vol. 19, H. 3. S. 1241-1251.

Pieters, J.. (2008) Manipulation of the Macrophage Response by Pathogenic Mycobacteria. In: Handbook of tuberculosis, [Vol. 1]: Molecular Biology and Biochemistry. Weinheim, S. 423.

Pieters, J.. (2008) Coronin 1 in innate immunity. Subcellular biochemistry, Vol. 48. S. 116-123.

Pieters, J.. (2008) Mycobacterium tuberculosis and the macrophage : maintaining a balance. Cell Host & Microbe, Vol. 3, H. 6. S. 399-407.

Pieters, J.. (2008) The role of signal transduction pathways in the survival of Mycobacterium tuberculosis inside macrophages. Cell Host & Microbe, H. 3. S. 399-407.

Mueller, P. and Massner, J. and Jayachandran, R. and Combaluzier, B. and Albrecht, I. and Gatfield, J. and Blum, C. and Ceredig, R. and Rodewald, H. R. and Rolink, A. G. and Pieters, J.. (2008) Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering. Nature Immunology, Vol. 9, H. 4. S. 424-431.

2007

Majlessi, L. and Combaluzier, B. and Albrecht, I. and Garcia, J. E. and Nouze, C. and Pieters, J. and Leclerc, C.. (2007) Inhibition of phagosome maturation by mycobacteria does not interfere with presentation of mycobacterial antigens by MHC molecules. Journal of immunology, Vol. 179, H. 3. S. 1825-1833.

Nguyen, L. and Scherr, N. and Gatfield, J. and Walburger, A. and Pieters, J. and Thompson, C. J.. (2007) Antigen 84, an effector of pleiomorphism in Mycobacterium smegmatis. Journal of bacteriology, 189 (21). pp. 7896-7910.

Sundaramurthy, V. and Pieters, J.. (2007) Interactions of pathogenic mycobacteria with host macrophages. Microbes and infection, Vol. 9, H. 14-15. S. 1671-1679.

Scherr, N. and Honnappa, S. and Kunz, G. and Mueller, P. and Jayachandran, R. and Winkler, F. and Pieters, J. and Steinmetz, M. O.. (2007) Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, H. 29. S. 12151-12156.

Mueller, P. and Quintana, A. and Griesemer, D. and Hoth, M. and Pieters, J.. (2007) Disruption of the cortical actin cytoskeleton does not affect store operated Ca2+ channels in human T-cells. FEBS letters, Vol. 581, H. 18. S. 3557-3562.

Jayachandran, R. and Sundaramurthy, V. and Combaluzier, B. and Mueller, P. and Korf, H. and Huygen, K. and Miyazaki, T. and Albrecht, I. and Massner, J. and Pieters, J.. (2007) Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell, Vol. 130, H. 1. S. 37-50.

2006

Albrecht, I. and Gatfield, J. and Mini, T. and Jeno, P. and Pieters, J.. (2006) Essential role for cholesterol in the delivery of exogenous antigens to the MHC class I-presentation pathway. International immunology, Vol. 18, H. 5. S. 755-765.

Houben, E. N. G. and Nguyen, L. and Pieters, J.. (2006) Interaction of pathogenic mycobacteria with the host immune system. Current opinion in microbiology, Vol. 9, H. 1. S. 76-85.

Mueller, P. and Pieters, J.. (2006) Modulation of macrophage antimicrobial mechanisms by pathogenic mycobacteria. Immunobiology, Vol. 211, H. 6-8. S. 549-556.

Floto, R. A. and MacAry, P. A. and Boname, J. M. and Mien, T. S. and Kampmann, B. and Hair, J. R. and Huey, O. S. and Houben, E. N. G. and Pieters, J. and Day, C. and Oehlmann, W. and Singh, M. and Smith, K. G. C. and Lehner, P. J.. (2006) Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5. Science, Vol. 314, no. 5798. S. 454-458.

Nguyen, Liem and Pieters, Jean. (2006) Battle for survival : interplay between pathogenic mycobacteria and the host immune system. Discovery Medicine, Vol. 6, H. 32. S. 82-86.

2005

Kammerer, R. A. and Kostrewa, D. and Progias, P. and Honnappa, S. and Avila, D. and Lustig, A. and Winkler, F. K. and Pieters, J. and Steinmetz, M. O.. (2005) A conserved trimerization motif controls the topology of short coiled coils. Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, H. 39. S. 13891-13896.

Morris, R. P. and Nguyen, L. and Gatfield, J. and Visconti, K. and Nguyen, K. and Schnappinger, D. and Ehrt, S. and Liu, Y. and Heifets, L. and Pieters, J. and Schoolnik, G. and Thompson, C. J.. (2005) Ancestral antibiotic resistance in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, H. 34. S. 12200-12205.

Nguyen, L. and Walburger, A. and Houben, E. and Koul, A. and Muller, S. and Morbitzer, M. and Klebl, B. and Ferrari, G. and Pieters, J.. (2005) Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG. Journal of bacteriology, 187 (16). pp. 5852-5856.

Gatfield, J. and Albrecht, I. and Zanolari, B. and Steinmetz, M. O. and Pieters, J.. (2005) Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules. Molecular biology of the cell, Vol. 16, H. 6. S. 2786-2798.

Nguyen, L. and Pieters, J.. (2005) The Trojan horse : survival tactics of pathogenic mycobacteria in macrophages. Trends in cell biology, Vol. 15, H. 5. S. 269-276.

Sonda, S. and Sala, G. and Ghidoni, R. and Hemphill, A. and Pieters, J.. (2005) Inhibitory effect of aureobasidin A on Toxoplasma gondii. Antimicrobial Agents and Chemotherapy, Vol. 49, H. 5. S. 1794-1801.

2004

Walburger, A. and Koul, A. and Ferrari, G. and Nguyen, L. and Prescianotto-Baschong, C. and Huygen, K. and Klebl, B. and Thompson, C. and Bacher, G. and Pieters, J.. (2004) Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science, Vol. 304, no. 5678. S. 1800-1804.

2003

Engering, A. and Kuhn, L. and Fluitsma, D. and Hoefsmit, E. and Pieters, J.. (2003) Differential post-translational modification of CD63 molecules during maturation of human dendritic cells. European journal of biochemistry, Vol. 270, H. 11. S. 2412-2420.

Gatfield, J. and Pieters, J.. (2003) Molecular mechanisms of host-pathogen interaction : entry and survival of mycobacteria in macrophages. Advances in immunology, Vol. 81. S. 45-96.

Pieters, J. and Ploegh, H.. (2003) Chemical warfare and mycobacterial defense. Science, 302, No. 5652. S. 1900-1902.

Dory, D. and Echchannaoui, H. and Letiembre, M. and Ferracin, F. and Pieters, J. and Adachi, Y. and Akashi, S. and Zimmerli, W. and Landmann, R.. (2003) Generation and functional characterization of a clonal murine periportal Kupffer cell line from H-2Kb -tsA58 mice. Journal of leukocyte biology, Vol. 74, no. 1. S. 49-59.

Pieters, J.. (2003) Molecular mechanisms regulating membrane traffic in macrophages : lessons from the intracellular pathogen mycobacterium spp. In: Intracellular pathogens in membrane interactions and vacuole biogenesis. Dordrecht ; London, S. 170-178.

Pieters, J.. (2003) Regulation of membrane fusion processes in eukaryotic cells : what can we learn from pathogenic mycobacteria? In: Microbial subversion of host cells. Cambridge.

2002

Pieters, J. and Gatfield, J.. (2002) Hijacking the host : survival of pathogenic mycobacteria inside macrophages. Trends in microbiology, Vol. 10, H. 3. S. 142-146.

2001

Engering, A. and Pieters, J.. (2001) Association of distinct tetraspanins with MHC class ll molecules at different subcellular locations in human immature dendritic cells. International immunology, Vol. 13. S. 127-34.

Pieters, J.. (2001) Entry and survival of pathogenic mycobacteria in macrophages. Microbes and infection, 3 (3). pp. 249-255.

Pieters, J.. (2001) Evasion of host cell defense mechanisms by pathogenic bacteria. Current opinion in immunology, 13 (1). pp. 37-44.

2000

Gatfield, J. and Ferrari, G. and Pieters, J.. (2000) Immunity against Extracellular Pathogens. Protoplasma, Vol. 210. S. 99-107.

Gatfield, J. and Pieters, J.. (2000) Essential role for cholesterol in entry of mycobacteria into macrophages. Science, 288 (5471). pp. 1647-1650.

Pieters, J.. (2000) MHC class ll-restricted antigen processing and presentation. Advances in immunology, Vol. 75. S. 159-208.

1999

Eynon, E. E. and Schlax, C. and Pieters, J.. (1999) A Secreted form of the MHC Class ll Associated Invariant Chain Inhibiting T cell Activation. Journal of biological chemistry, Vol. 274. S. 26266-26271.

Ferrari, G. and Langen, H. and Naito, M. and Pieters, J.. (1999) A coat protein on phagosomes involved in the intracellular survival of mycobacteria. Cell, 97 (4). pp. 435-447.

Pieters, J.. (1999) Processing and presentation of phagocytosed antigens to the immune system. In: Phagocytosis: the host. Stamford, Conn., S. 379-406.

1998

Hasan, Z. and Pieters, J.. (1998) Subcellular fractionation by organelle electrophoresis : separation of phagosomes containing heat-killed yeast particles. Electrophoresis, 19 (7). pp. 1179-1184.

Engering, A. J. and Richters, C. D. and Fluitsma, D. M. and van Pelt, A. M. and Kamperdijk, E. W. and Hoefsmit, E. C. and Pieters, J.. (1998) MHC class II and invariant chain biosynthesis and transport during maturation of human precursor dendritic cells. International immunology, Vol. 10, no. 11. S. 1713-1723.

1997

Engering, A. J. and Cella, M. and Fluitsma, D. and Brockhaus, M. and Hoefsmit, E. C. and Lanzavecchia, A. and Pieters, J.. (1997) The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells. European Journal of Immunology, Vol. 27, H. 9. S. 2417-2425.

Ferrari, G. and Knight, A. M. and Watts, C. and Pieters, J.. (1997) Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules. The Journal of cell biology, Vol. 139, H. 6. S. 1433-1446.

Hasan, Z. and Schlax, C. and Kuhn, L. and Lefkovits, I. and Young, D. and Thole, J. and Pieters, J.. (1997) Isolation and characterization of the mycobacterial phagosome : segregation from the endosomal/lysosomal pathway. Molecular microbiology, Vol. 24, H. 3. S. 545-553.

Pieters, J.. (1997) MHC class ll-restricted antigen processing and presentation. Current opinion in immunology, Vol. 9. S. 89-96.

Cella, M. and Engering, A. and Pinet, V. and Pieters, J. and Lanzavecchia, A.. (1997) Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature, 388 (6644). pp. 782-787.

Engering, A. and Lefkovits, I. and Pieters, J.. (1997) Analysis of subcellular organelles involved in major histocompatibility complex (MHC) class II-restricted antigen presentation by electrophoresis. Electrophoresis, Vol. 18, H. 14. S. 2523-2530.

Pieters, J.. (1997) MHC class ll compartments : specialized organelles of the endocytic pathway in antigen presenting cells. Biological chemistry, Vol. 378. S. 751-758.

Engering, A. J. and Cella, M. and Fluitsma, D. M. and Hoefsmit, E. C. and Lanzavecchia, A. and Pieters, J.. (1997) Mannose receptor mediated antigen uptake and presentation in human dendritic cells. Advances in experimental medicine and biology, 417. S. 183-187.

1994

Tulp, A. and Verwoerd, D. and Dobberstein, B. and Ploegh, HL. and Pieters, J.. (1994) Isolation and characterization of the intracellular MHC class II compartment. Nature, Vol. 369. S. 120-126.

1993

Tulp, A. and Verwoerd, D. and Pieters, J.. (1993) Application of an improved density gradient electrophoresis apparatus to the separation of proteins, cells and subcellular organelles. Electrophoresis, Vol. 14, H. 12. S. 1295-1301.

Pieters, J. and Bakke, O. and Dobberstein, B.. (1993) The MHC class ll-associated Invariant chain contains two endosomal sorting signals within its cytoplasmic tail. Journal of cell science, Vol. 106. S. 831-846.

1991

Pieters, J. and Horstmann, H. and Bakke, O. and Griffiths, G. and Lipp, J.. (1991) Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain. The Journal of cell biology, Vol. 115, H. 5. S. 1213-1223.

1990

Pieters, J. and Lindhout, T. and Willems, G.. (1990) Heparin-stimulated inhibition of factor lXa generation and factor lXa neutralization in plasma. Blood, Vol. 76. S. 549-554.

1989

Pieters, J. and Lindhout, T. and Hemker, H. C.. (1989) In situ-generated thrombin is the only enzyme that effectively activates factor VIII and factor V in thromboplastin-activated plasma. Blood, Vol. 74, H. 3. S. 1021-1024.

Hemker, H. C. and Beguin, S. and Pieters, J. and Lindhout, T.. (1989) The ex vivo correlate of the antithrombotic action of heparin. Annals of the New York Academy of Sciences, Vol. 556. S. 146-157.

1988

Maurer-Fogy, I. and Reutelingsperger, C. P. and Pieters, J. and Bodo, G. and Stratowa, C. and Hauptmann, R.. (1988) Cloning and expression of cDNA for human vascular anticoagulant, a Ca2+-dependent phospholipid-binding protein. European journal of biochemistry, Vol. 174, H. 4. S. 585-592.

Pieters, J. and Willems, G. and Hemker, H. C. and Lindhout, T.. (1988) Inhibition of faxtor lXa and factor Xa by antithrombin lll/heparin during factor X activation. Journal of biological chemistry, Vol. 263. S. 15313-15318.

Pieters, J. and Lindhout, T.. (1988) The limited importance of factor Xa inhibition to the anticoagulant property of heparin in thromboplastin-activated plasma. Blood, Vol. 72, H. 6. S. 2048-2052.

1987

Pieters, J. and Franssen, J. and Visch, C. and Lindhout, T.. (1987) Neutralization of heparin by prothrombin activation products. Thrombosis Research, Vol. 45, H. 5. S. 573-580.