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Items where contributor is "Huwyler, Jörg"

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2016

Kettiger, Helene and Québatte, Gabriela and Perrone, Barbara and Huwyler, Jörg. (2016) Interactions between silica nanoparticles and phospholipid membranes. Biochimica et biophysica acta, 1858 (9). pp. 2163-2170.

Preisig, Daniel and Roth, Roger and Tognola, Sandy and Varum, Felipe J. O. and Bravo, Roberto and Cetinkaya, Yalcin and Huwyler, Jörg and Puchkov, Maxim. (2016) Mucoadhesive microparticles for local treatment of gastrointestinal diseases. European journal of pharmaceutics and biopharmaceutics, 105. pp. 156-165.

Buck, Jonas and Huwyler, Jörg and Kühl, Peter and Dischinger, Angela. (2016) Pediatric Dispersible Tablets: a Modular Approach for Rapid Prototyping. Pharmaceutical research, 33 (8). pp. 2043-2055.

Witzigmann, Dominik and Quagliata, Luca and Schenk, Susanne H. and Quintavalle, Cristina and Terracciano, Luigi M. and Huwyler, Jörg. (2016) Variable asialoglycoprotein-receptor 1 expression in liver disease: Implications for therapeutic intervention. Hepatology research , 46 (7). pp. 686-696.

Eberle, Veronika A. and Häring, Armella and Schoelkopf, Joachim and Gane, Patric A. C. and Huwyler, Jörg and Puchkov, Maxim. (2016) In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets. Drug development and industrial pharmacy, 42 (5). pp. 808-817.

Riede, Julia and Poller, Birk and Umehara, Ken-ichi and Huwyler, Jörg and Camenisch, Gian. (2016) New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data. European journal of pharmaceutical sciences, 86. pp. 96-102.

Mathaes, Roman and Mahler, Hanns-Christian and Buettiker, Jean-Pierre and Roehl, Holger and Lam, Philippe and Brown, Helen and Luemkemann, Joerg and Adler, Michael and Huwyler, Jörg and Streubel, Alexander and Mohl, Silke. (2016) The pharmaceutical vial capping process; Container closure systems, capping equipment, regulatory framework, and seal quality tests. European journal of pharmaceutics and biopharmaceutics, 99. pp. 54-64.

Ríos Quiroz, Anacelia and Lamerz, Jens and De Cunha, Thierry and Boillon, Adeline and Adler, Michael and Finkler, Christof and Huwyler, Jörg and Schmidt, Roland and Mahler, Hanns-Christian and Koulov, Atanas V.. (2016) Factors Governing the Precision of Subvisible Particle Measurement Methods - A Case Study with a Low-Concentration Therapeutic Protein Product in a Prefilled Syringe. Pharmaceutical research, 33 (2). pp. 450-461.

Mathaes, Roman and Mahler, Hanns-Christian and Roggo, Yves and Ovadia, Robert and Lam, Philippe and Stauch, Oliver and Vogt, Martin and Roehl, Holger and Huwyler, Joerg and Mohl, Silke and Streubel, Alexander. (2016) Impact of Vial Capping on Residual Seal Force and Container Closure Integrity. PDA Journal of Pharmaceutical Science and Technology, 70 (1). pp. 12-29.

Grossen, Philip and Québatte, Gabriela and Witzigmann, Dominik and Prescianotto-Baschong, Cristina and Dieu, Le-Ha and Huwyler, Jörg. (2016) Functionalized Solid-Sphere PEG-b-PCL Nanoparticles to Target Brain Capillary Endothelial Cells In Vitro. Journal of Nanomaterials, 2016. p. 7818501.

2015

Kettiger, Helene and Karaman, Didem Sen and Schiesser, Laura and Rosenholm, Jessica M. and Huwyler, Jörg. (2015) Comparative safety evaluation of silica-based particles. Toxicology in vitro, 30 (1). pp. 355-363.

Boll, Björn and Folzer, Emilien and Finkler, Christof and Huwyler, Jörg and Mahler, Hanns-Christian and Schmidt, Roland and Koulov, Atanas V.. (2015) Comparative Evaluation of Two Methods for Preparative Fractionation of Proteinaceous Subvisible Particles-Differential Centrifugation and FACS. Pharmaceutical research, 32 (12). pp. 3952-3964.

Folzer, Emilien and Khan, Tarik and Schmidt, Roland and Finkler, Christof and Huwyler, Jörg and Mahler, Hanns-Christian and Koulov, Atanas V.. (2015) Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator. Journal of pharmaceutical sciences, 104 (12). pp. 4034-4040.

Allmendinger, Andrea and Mueller, Robert and Huwyler, Jörg and Mahler, Hans-Christian and Fischer, Stefan. (2015) Sterile Filtration of Highly Concentrated Protein Formulations: Impact of Protein Concentration, Formulation Composition, and Filter Material. Journal of pharmaceutical sciences, 104 (10). pp. 3319-3329.

Kunze, Annett and Poller, Birk and Huwyler, Jörg and Camenisch, Gian. (2015) Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins. Drug Metabolism and Personalized Therapy, 30 (3). pp. 175-188.

Folzer, Emilien and Diepold, Katharina and Bomans, Katrin and Finkler, Christof and Schmidt, Roland and Bulau, Patrick and Huwyler, Jörg and Mahler, Hanns-Christian and Koulov, Atanas V.. (2015) Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule. Journal of pharmaceutical sciences, 104 (9). pp. 2824-2831.

Werk, Tobias and Huwyler, Jörg and Hafner, Mathias and Luemkemann, Jörg and Mahler, Hanns-Christian. (2015) An Impedance-Based Method to Determine Reconstitution Time for Freeze-Dried Pharmaceuticals. Journal of pharmaceutical sciences, 104 (9). pp. 2948-2955.

Allmendinger, Andrea and Mueller, Robert and Schwarb, Edward and Chipperfield, Mark and Huwyler, Jörg and Mahler, Hanns-Christian and Fischer, Stefan. (2015) Measuring Tissue Back-Pressure - In Vivo Injection Forces During Subcutaneous Injection. Pharmaceutical research, 32 (7). pp. 2229-2240.

Preisig, Daniel and Weingartner, Michael and Varum, Felipe J. O. and Bravo, Roberto and Alles, Rainer and Huwyler, Jörg and Puchkov, Maxim. (2015) Marker-ion analysis for quantification of mucoadhesivity of microparticles in particle-retention assays. International journal of pharmaceutics, 487 (1-2). pp. 157-166.

Camenisch, Gian and Riede, Julia and Kunze, Annett and Huwyler, Jörg and Poller, Birk and Umehara, Kanichi. (2015) The extended clearance model and its use for the interpretation of hepatobiliary elimination data. ADMET & DMPK, 3 (1). pp. 1-14.

Seeland, Swen and Kettiger, Helene and Murphy, Mark and Treiber, Alexander and Giller, Jasmin and Kiss, Andrea and Sube, Romain and Krähenbühl, Stephan and Hafner, Mathias and Huwyler, Jörg. (2015) ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor. Pharmacology Research & Perspecitves, 3 (2). e00123.

Wicki, Andreas and Witzigmann, Dominik and Balasubramanian, Vimalkumar and Huwyler, Jörg. (2015) Nanomedicine in cancer therapy : challenges, opportunities, and clinical applications. Journal of controlled release, 200. pp. 138-157.

Jaeschke, Georg and Kolczewski, Sabine and Spooren, Will and Vieira, Eric and Bitter-Stoll, Nadia and Boissin, Patrick and Borroni, Edilio and Büttelmann, Bernd and Ceccarelli, Simona and Clemann, Nicole and David, Beatrice and Funk, Christoph and Guba, Wolfgang and Harrison, Anthony and Hartung, Thomas and Honer, Michael and Huwyler, Jörg and Kuratli, Martin and Niederhauser, Urs and Pähler, Axel and Peters, Jens-Uwe and Petersen, Ann and Prinssen, Eric and Ricci, Antonio and Rueher, Daniel and Rueher, Marianne and Schneider, Manfred and Spurr, Paul and Stoll, Theodor and Tännler, Daniel and Wichmann, Jürgen and Porter, Richard H. and Wettstein, Joseph G. and Lindemann, Lothar. (2015) Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases. Journal of medicinal chemistry, 58 (3). pp. 1358-1371.

Keiser, Jenifer and [et al.], . (2015) Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infection : a four-arm, randomised controlled trial. The Lancet infectious diseases, Vol. 15, H. 3. S. 277-284.

Ríos Quiroz, Anacelia and Québatte, Gabriela and Stump, Fabian and Finkler, Christof and Huwyler, Joerg and Schmidt, Roland and Mahler, Hanns-Christian and Koulov, Atanas V. and Adler, Michael. (2015) Measuring Subvisible Particles in Protein Formulations Using a Modified Light Obscuration Sensor with Improved Detection Capabilities. Analytical chemistry, Vol. 87, H. 12. S. 6119-6124.

Witzigmann, Dominik and Sieber, Sandro and Porta, Fabiola and Grossen, Philip and Bieri, Andrej and Strelnikova, Natalja and Pfohl, Thomas and Prescianotto-Baschong, Cristina and Huwyler, Jörg. (2015) Formation of lipid and polymer based gold nanohybrids using a nanoreactor approach. RSC Advances, 5 (91). pp. 74320-74328.

Duthaler, Urs and Keiser, Jennifer and Huwyler, Jörg. (2015) LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots. Journal of pharmaceutical and biomedical analysis, 105. pp. 163-173.

Witzigmann, Dominik and Wu, Dalin and Schenk, Susanne H. and Balasubramanian, Vimalkumar and Meier, Wolfgang and Huwyler, Jörg. (2015) Biocompatible Polymer-Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery. ACS applied materials & interfaces, 7 (19). pp. 10446-10456.

Moser, Wendelin and Ali, Said M. and Ame, Shaali M. and Speich, Benjamin and Puchkov, Maxim and Huwyler, Jörg and Albonico, Marco and Hattendorf, Jan and Keiser, Jennifer. (2015) Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study. The Lancet infectious diseases, 16 (1). pp. 53-60.

2014

Detampel, Pascal and Witzigmann, Dominik and Krähenbühl, Stephan and Huwyler, Jörg. (2014) Hepatocyte targeting using pegylated asialofetuin-conjugated liposomes. Journal of drug targeting, Vol. 22, No. 3. S. 232-241.

Speich, Benjamin and Ame, Shaali M. and Ali, Said M. and Alles, Rainer and Huwyler, Jörg and Hattendorf, Jan and Utzinger, Jürg and Albonico, Marco and Keiser, Jennifer. (2014) Oxantel pamoate-albendazole for Trichuris trichiura infection. The New England journal of medicine, Vol. 370, H. 7. S. 610-620.

Dieu, Le-Ha and Wu, Dalin and Palivan, Cornelia G. and Balasubramanian, Vimalkumar and Huwyler, Jörg. (2014) Polymersomes conjugated to 83-14 monoclonal antibodies : in vitro targeting of brain capillary endothelial cells. European journal of pharmaceutics and biopharmaceutics, 88 (2). pp. 316-324.

Eberle, V. A. and Schoelkopf, J. and Gane, P. A. and Alles, R. and Huwyler, J. and Puchkov, M.. (2014) Floating gastroretentive drug delivery systems : comparison of experimental and simulated dissolution profiles and floatation behavior. European journal of pharmaceutical sciences, Vol. 58. S. 34-43.

Kunze, A. and Huwyler, J. and Camenisch, G. and Poller, B.. (2014) Prediction of OATP1B1 and OATP1B3 Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity Data. Drug metabolism and disposition, Vol. 42, H. 9. S. 1514-1521.

Kunze, A. and Huwyler, J. and Poller, B. and Gutmann, H. and Camenisch, G.. (2014) In vitro-in vivo extrapolation method to predict human renal clearance of drugs. Journal of pharmaceutical sciences, Vol. 103, H. 3. S. 994-1001.

Preisig, D. and Haid, D. and Varum, F. J. and Bravo, R. and Huwyler, J. and Puchkov, M.. (2014) Drug loading into porous calcium carbonate microparticles by solvent evaporation. European journal of pharmaceutics and biopharmaceutics, Vol. 87, H. 3. S. 548-558.

Camblin, M. and Detampel, P. and Kettiger, H. and Wu, D. and Balasubramanian, V. and Huwyler, J.. (2014) Polymersomes containing quantum dots for cellular imaging. International journal of nanomedicine, Vol. 9. S. 2287-2298.

Stirnimann, T. and Atria, S. and Schoelkopf, J. and Gane, P. A. and Alles, R. and Huwyler, J. and Puchkov, M.. (2014) Compaction of functionalized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface. International journal of pharmaceutics, Vol. 466, H. 1-2 , S. 266–275.

Allmendinger, A. and Dieu, L. H. and Fischer, S. and Mueller, R. and Mahler, H. C. and Huwyler, J.. (2014) High-throughput viscosity measurement using capillary electrophoresis instrumentation and its application to protein formulation. Journal of pharmaceutical and biomedical analysis, Vol. 99. S. 51-58.

Allmendinger, A. and Fischer, S. and Huwyler, J. and Mahler, H. C. and Schwarb, E. and Zarraga, I. E. and Mueller, R.. (2014) Rheological characterization and injection forces of concentrated protein formulations : an alternative predictive model for non-Newtonian solutions. European journal of pharmaceutics and biopharmaceutics, Vol. 87, H. 2. S. 318-328.

Mueller, B. and Hieber, S. E. and Zumbuehl, A. and Walter, M. A. and Huwyler, J. and Pfohl, T. and Cattin, Ph. C.. (2014) Translational medicine : nanoscience and nanotechnology to improve patient care. In: The nano-micro interface. Weinheim, S. 291-309.

2013

Stirnimann, Tanja and Di Maiuta, Nicola and Gerard, Daniel E. and Alles, Rainer and Huwyler, Jörg and Puchkov, Maxim. (2013) Functionalized Calcium Carbonate as a Novel Pharmaceutical Excipient for the Preparation of Orally Dispersible Tablets. Pharmaceutical research, Vol. 30, H. 7. S. 1915-1925.

Fasler-Kan, E. and Barteneva, N. S. and Ketterer, S. and Wunderlich, K. and Reschner, A. and Nurzhanova, A. and Flammer, J. and Huwyler, J. and Meyer, P.. (2013) Human cytokines activate JAK-STAT signaling pathway in porcine ocular tissue. Xenotransplantation, Vol. 20, H. 6. S. 469-480.

Kettiger, H. and Schipanski, A. and Wick, P. and Huwyler, J.. (2013) Engineered nanomaterial uptake and tissue distribution : from cell to organism. International journal of nanomedicine, Vol. 8. S. 3255-3269.

Seeland, S. and Torok, M. and Kettiger, H. and Treiber, A. and Hafner, M. and Huwyler, J.. (2013) A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells. Toxicology in vitro, Vol. 27, H. 3. S. 1109-1120.

Schoenbaechler, A. and Olfa, G. and Huwyler, J. and Frenz, M. and Pieles, U.. (2013) Indocyanine green loaded biocompatible nanoparticles: Stabilization of indocyanine green (ICG) using biocompatible silica-poly(; e; -caprolactone) grafted nanocomposites. Journal of photochemistry and photobiology. A, Chemistry, Vol. 261. S. 12-19.

Meister, Isabel and Duthaler, Urs and Huwyler, Jörg and Rinaldi, Laura and Bosco, Antonio and Cringoli, Giuseppe and Keiser, Jennifer. (2013) Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with Fasciola hepatica in sheep. Veterinary parasitology, Vol. 198, H. 1-2. S. 102-110.

Alles, R. and Puchkov, M. and Jablonski, C. and Speich, B. and Keiser, J. and Huwyler, J.. (2013) Development of oxantel tablets for pediatric clinical studies : a technical note. Journal of drug delivery science and technology, Vol. 23, H. 6. S. 623-625.

2012

Kunze, A. and Huwyler, J. and Camenisch, G. and Gutmann, H.. (2012) Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters. Biochemical pharmacology, Vol. 84, Issue 8. S. 1096-1102.

Suenderhauf, C. and Hammann, F. and Huwyler, J.. (2012) Computational Prediction of Blood-Brain Barrier Permeability Using Decision Tree Induction. Molecules, Vol. 17, H. 9. S. 10429-10445.

Duthaler, U. and Huwyler, J. and Rinaldi, L. and Cringoli, G. and Keiser, J.. (2012) Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica. Veterinary parasitology, Vol. 186, H. 3-4. S. 270-280.

Hysek, C. M. and Simmler, L. D. and Nicola, V. G. and Vischer, N. and Donzelli, M. and Krahenbuhl, S. and Grouzmann, E. and Huwyler, J. and Hoener, M. C. and Liechti, M. E.. (2012) Duloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study. PLoS one, Vol. 7, H. 5 , e36476.

Simmler, L. D. and Buser, T. A. and Donzelli, M. and Schramm, Y. and Dieu, L. H. and Huwyler, J. and Chaboz, S. and Hoener, M. C. and Liechti, M. E.. (2012) Pharmacological characterization of designer cathinones in vitro. British journal of pharmacology, Vol. 168, no. 2. S. 458-470.

Kirchhofer, C. and Vargas, M. and Huwyler, J. and Keiser, J.. (2012) Pharmacokinetics of the fasciocidal drug candidates MT04 and OZ78 in uninfected rats and in vitro pharmacodynamic studies. International journal for parasitology: drugs and drug resistance, Vol. 2. S. 121-125.

Detampel, Pascal and Beck, Mareike and Krähenbühl, Stephan and Huwyler, Jörg. (2012) Drug interaction potential of resveratrol. Drug metabolism reviews, Vol. 44, H. 3. S. 253-65.

Sano, Y. and Kashiwamura, Y. and Abe, M. and Dieu, L. H. and Huwyler, J. and Shimizu, F. and Haruki, H. and Maeda, T. and Saito, K. and Tasaki, A. and Kanda, T.. (2012) A stable human brain microvascular endothelial cell line retaining its barrier-specific nature, independent of the passage number. Clinical and experimental neuroimmunology, Vol. 3. S. 1-12.

2011

Suenderhauf, Claudia and Hammann, Felix and Maunz, Andreas and Helma, Christoph and Huwyler, Jörg. (2011) Combinatorial QSAR Modeling of human Intestinal Absorption. Molecular pharmaceutics, Vol. 8, H. 1. S. 213-224.

Schroeder, K. and Bremm, K. D. and Alepee, N. and Bessems, J. G. and Blaauboer, B. and Boehn, S. N. and Burek, C. and Coecke, S. and Gombau, L. and Hewitt, N. J. and Heylings, J. and Huwyler, J. and Jaeger, M. and Jagelavicius, M. and Jarrett, N. and Ketelslegers, H. and Kocina, I. and Koester, J. and Kreysa, J. and Note, R. and Poth, A. and Radtke, M. and Rogiers, V. and Scheel, J. and Schulz, T. and Steinkellner, H. and Toeroek, M. and Whelan, M. and Winkler, P. and Diembeck, W.. (2011) Report from the EPAA workshop : in vitro ADME in safety testing used by EPAA industry sectors. Toxicology in vitro, Vol. 25, H. 3. S. 589-604.

Hammann, F. and Suenderhauf, C. and Huwyler, J.. (2011) A Binary Ant Colony Optimization Classifier for Molecular Activities. Journal of Chemical Information and Modeling, Vol. 51. S. 2690-2696.

Seeland, S. and Treiber, A. and Hafner, M. and Huwyler, J.. (2011) On-line identification of P-glycoprotein substrates by monitoring of extracellular acidification and respiration rates in living cells. Biochimica et biophysica acta, Vol. 1808, H. 7. S. 1827-1831.

Schmutz, Hans-Rudolf and Detampel, Pascal and Bühler, Theo and Büttler, André and Gygax, Benjamin and Huwyler, Jörg. (2011) In Vitro Assessment of the Formation of Ceftriaxone-Calcium Precipitates in Human Plasma. Journal of pharmaceutical sciences, Vol. 100, H. 6. S. 2300-2310.

Duthaler, Urs and Keiser, Jennifer and Huwyler, Jörg. (2011) Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether, and their major metabolites dihydroartemisinin and dihydroartemisininglucuronide in sheep plasma. Journal of mass spectrometry, Vol. 46, H. 2. S. 172-181.

Hysek, C. M. and Simmler, L. D. and Ineichen, M. and Grouzmann, E. and Hoener, M. C. and Brenneisen, R. and Huwyler, J. and Liechti, M. E.. (2011) The Norepinephrine Transporter Inhibitor Reboxetine Reduces Stimulant Effects of MDMA ("Ecstasy") in Humans. Clinical pharmacology and therapeutics, Vol. 90, H. 2. S. 246-255.

2010

Poller, Birk and Drewe, Jürgen and Krähenbühl, Stephan and Huwyler, Jörg and Gutmann, Heike. (2010) Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier. Cellular and Molecular Neurobiology, Vol. 30, No. 1. S. 63-70.

Keiser, Jennifer and Kirchhofer, Carla and Haschke, Manuel and Huwyler, Jörg and Dong, Yuxiang and Vennerstrom, Jonathan L. and Vanhoff, Kathleen and Kaminsky, Ronald and Malikides, Nick. (2010) Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep. Veterinary parasitology, Vol. 173, H. 3-4. S. 228-235.

Mattei, P. and Boehringer, M. and Di Giorgio, P. and Fischer, H. and Hennig, M. and Huwyler, J. and Kocer, B. and Kuhn, B. and Loeffler, B. M. and Macdonald, A. and Narquizian, R. and Rauber, E. and Sebokova, E. and Sprecher, U.. (2010) Discovery of carmegliptin : a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorganic & medicinal chemistry letters, Vol. 20, H. 3. S. 1109-1113.

Kirchhofer, C. and Keiser, J. and Huwyler, J.. (2010) Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate. Journal of chromatography B, Vol. 878, H. 28. S. 2770-2774.

Fasler-Kan, Elizaveta and Suenderhauf, Claudia and Barteneva, Natasha and Poller, Birk and Gygax, Daniel and Huwyler, Jörg. (2010) Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3. Brain research, Vol. 1354. S. 15-22.

Woltering, Thomas J. and Wichmann, Jürgen and Goetschi, Erwin and Knoflach, Frédéric and Ballard, Theresa M. and Huwyler, Jörg and Gatti, Silvia. (2010) Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives : Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists. Bioorganic & medicinal chemistry letters, Vol. 20, H. 23. S. 6969-6974.

Richter, H. G. and Freichel, C. and Huwyler, J. and Nakagawa, T. and Nettekoven, M. and Plancher, J. M. and Raab, S. and Roche, O. and Schuler, F. and Taylor, S. and Ullmer, C. and Wiegand, R.. (2010) Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold. Bioorganic & medicinal chemistry letters, Vol. 20, H. 19. S. 5713-5717.

Boehringer, M. and Fischer, H. and Hennig, M. and Hunziker, D. and Huwyler, J. and Kuhn, B. and Loeffler, B. M. and Luebbers, T. and Mattei, P. and Narquizian, R. and Sebokova, E. and Sprecher, U. and Wessel, H. P.. (2010) Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors. Bioorganic & medicinal chemistry letters, Vol. 20, H. 3. S. 1106-1108.

Fasler-Kan, E. and Barteneva, N. and Ketterer, S. and Wunderlich, K. and Huwyler, J. and Gygax, D. and Flammer, J. and Meyer, P.. (2010) Activation of the JAK?STAT intracellular pathway in human retinal pigment epithelialcell line ARPE-19. International Journal of Interferon, Cytokine and Mediator Research, Vol. 2. S. 127-136.