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Items where contributor is "Gillingwater, Kirsten"

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2022

Perieteanu, M. C. and McGee, L. M. C. and Shaw, C. D. and MacMillan, D. S. and Khalaf, A. I. and Gillingwater, K. and Beveridge, R. and Carter, K. C. and Suckling, C. J. and Scott, F. J.. (2022) Selective anti-leishmanial strathclyde minor groove binders using an N-oxide tail-group modification. Int J Mol Sci, 23 (19). p. 11912.

Smith, A. and Wall, R. J. and Patterson, S. and Rowan, T. and Rico Vidal, E. and Stojanovski, L. and Huggett, M. and Hampton, S. E. and Thomas, M. G. and Corpas Lopez, V. and Gillingwater, K. and Duke, J. and Napier, G. and Peter, R. and Vitouley, H. S. and Harrison, J. R. and Milne, R. and Jeacock, L. and Baker, N. and Davis, S. H. and Simeons, F. and Riley, J. and Horn, D. and Brun, R. and Zuccotto, F. and Witty, M. J. and Wyllie, S. and Read, K. D. and Gilbert, I. H.. (2022) Repositioning of a diaminothiazole series confirmed to target the cyclin-dependent kinase CRK12 for Use in the TREATMENT of African animal trypanosomiasis. Journal of medicinal chemistry, 65 (7). pp. 5606-5624.

2021

Brooke, D. P. and McGee, L. M. C. and Giordani, F. and Cross, J. M. and Khalaf, A. I. and Irving, C. and Gillingwater, K. and Shaw, C. D. and Carter, K. C. and Barrett, M. P. and Suckling, C. J. and Scott, F. J.. (2021) Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype. RSC Medicinal Chemistry, 12 (8). pp. 1391-1401.

Brooke, D. P. and McGee, L. M. C. and Giordani, F. and Cross, J. M. and Khalaf, A. I. and Irving, C. and Gillingwater, K. and Shaw, C. D. and Carter, K. C. and Barrett, M. P. and Suckling, C. J. and Scott, F. J.. (2021) Correction: Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype. RSC Med Chem, 12 (12). p. 2071.

2020

Singh, B. and Diaz-Gonzalez, R. and Ceballos-Perez, G. and Rojas-Barros, D. I. and Gunaganti, N. and Gillingwater, K. and Martinez-Martinez, M. S. and Manzano, P. and Navarro, M. and Pollastri, M. P.. (2020) Medicinal chemistry optimization of a diaminopurine chemotype: toward a lead for Trypanosoma brucei inhibitors. Journal of medicinal chemistry, 63 (17). pp. 9912-9927.

2019

GIordani, F. and Khalaf, A. I. and Gillingwater, K. and Munday, J. C. and De Koning, H. P. and Suckling, C. J. and Barrett, M. P. and Scott, F. J.. (2019) Novel minor groove binders cure animal african trypanosomiasis in an in vivo mouse model. Journal of medicinal chemistry, 62 (6). pp. 3021-3035.

2018

Gillingwater, Kirsten. (2018) In vitro and in vivo efficacy of diamidines against Trypanosoma equiperdum strains. Parasitology, 145 (7). pp. 953-960.

Begolo, Daniela and Vincent, Isabel M. and Giordani, Federica and Pöhner, Ina and Witty, Michael J. and Rowan, Timothy G. and Bengaly, Zakaria and Gillingwater, Kirsten and Freund, Yvonne and Wade, Rebecca C. and Barrett, Michael P. and Clayton, Christine. (2018) The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing. PLoS Pathogens, 14 (9). e1007315.

Ferrins, Lori and Sharma, Amrita and Thomas, Sarah M. and Mehta, Naimee and Erath, Jessey and Tanghe, Scott and Leed, Susan E. and Rodriguez, Ana and Mensa-Wilmot, Kojo and Sciotti, Richard J. and Gillingwater, Kirsten and Pollastri, Michael P.. (2018) Anilinoquinoline based inhibitors of trypanosomatid proliferation. PLoS Neglected Tropical Diseases, 12 (11). e0006834.

Oufir, M. Gillingwater and K. Hamburger, M. Roditi and I. Brun, R. Mäser and P. Wenzler, T.. (2018) Pharmacokinetic profiles reconcile in vitro and in vivo activities of novel trypanocidal compounds. Matters. 07000009.

Gysin, M. and Braissant, O. and Gillingwater, K. and Brun, R. and Mäser, P. and Wenzler, T.. (2018) Isothermal microcalorimetry - a quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time. International journal for parasitology. Drugs and drug resistance, 8 (2). pp. 159-164.

2017

Gillingwater, Kirsten and Kunz, Christina and Braghiroli, Christiane and Boykin, David W. and Tidwell, Richard R. and Brun, Reto. (2017) In vitro, ex vivo and in vivo activity of diamidines against Trypanosoma congolense and Trypanosoma vivax. Antimicrobial agents and chemotherapy, 61 (5). e02356-16.

Scott, Fraser J. and Nichol, Ryan J. O. and Khalaf, Abedawn I. and Giordani, Federica and Gillingwater, Kirsten and Ramu, Soumya and Elliott, Alysha and Zuegg, Johannes and Duffy, Paula and Rosslee, Michael-Jon and Hlaka, Lerato and Kumar, Santosh and Ozturk, Mumin and Brombacher, Frank and Barrett, Michael and Guler, Reto and Suckling, Colin J.. (2017) An evaluation of minor groove binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136. pp. 561-572.

Akama, T. and Zhang, Y. K. and Freund, Y. R. and Berry, P. and Lee, J. and Easom, E. E. and Jacobs, R. T. and Plattner, J. J. and Witty, M. J. and Peter, R. and Rowan, T. G. and Gillingwater, K. and Brun, R. and Nare, B. and Mercer, L. and Xu, M. and Wang, J. and Liang, H.. (2017) Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT). Bioorganic and Medicinal Chemistry Letters, 28. pp. 6-10.

2013

Rogé, S. and Van Reet, N. and Odiwuor, S. and Tran, T. and Schildermans, K. and Vandamme, S. and Vandenberghe, I. and Vervecken, W. and Gillingwater, K. and Claes, F. and Devreese, B. and Guisez, Y. and Büscher, P.. (2013) Recombinant expression of trypanosome surface glycoproteins in Pichia pastoris for the diagnosis of Trypanosoma evansi infection. Veterinary parasitology : an international scientific journal, Vol. 197, H. 3-4. pp. 571-579.

2007

Gillingwater, Kirsten. Discovery of novel active diamidines as clinical candidates against "Trypanosoma evansi" infection. 2007, Doctoral Thesis, University of Basel, Faculty of Science.