Items where contributor is "Christofori, Gerhard M."

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Bill, Ruben and Christofori, Gerhard. (2015) The relevance of EMT in breast cancer metastasis: Correlation or causality? FEBS letters, 589 (14). pp. 1577-1587.

Archetti, Marco and Ferraro, Daniela A. and Christofori, Gerhard. (2015) Reply to Gerlee and Altrock : diffusion and population size in game theory models of cancer. Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, H. 21 , E2744.

Fagiani, Ernesta and Bill, Ruben and Pisarsky, Laura and Ivanek, Robert and Rüegg, Curzio and Christofori, Gerhard. (2015) An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models. Angiogenesis, Vol. 18 H. 3. S. 327-345.

Schlegel, Natalie C. and von Planta, Anina and Widmer, Daniel S. and Dummer, Reinhard and Christofori, Gerhard. (2015) PI3K signalling is required for a TGFβ-induced epithelial-mesenchymal-like transition (EMT-like) in human melanoma cells. Experimental dermatology, Vol. 24, H. 1. S. 22-28.

Archetti, Marco and Ferraro, Daniela A. and Christofori, Gerhard. (2015) Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, H. 6. S. 1833-1838.

Meguenani, Mehdi and Miljkovic-Licina, Marijana and Fagiani, Ernesta and Ropraz, Patricia and Hammel, Philippe and Aurrand-Lions, Michel and Adams, Ralf H. and Christofori, Gerhard and Imhof, Beat A. and Garrido-Urbani, Sarah. (2015) Junctional adhesion molecule B interferes with angiogenic VEGF/VEGFR2 signaling. The FASEB Journal, Vol. 29, H. 8. S. 3411-3425.


Wicki, Andreas and Wild, Damian and Prêtre, Vincent and Mansi, Rosalba and Orleth, Annette and Reubi, Jean-Claude and Rochlitz, Christoph and Mamot, Christoph and Mäcke, Helmut R. and Christofori, Gerhard. (2014) Synergism of peptide receptor-targeted Auger electron radiation therapy with anti-angiogenic compounds in a mouse model of neuroendocrine tumors. EJNMMI research, 4. p. 9.

Diepenbruck, Maren and Waldmeier, Lorenz and Ivanek, Robert and Berninger, Philipp and Arnold, Phil and van Nimwegen, Erik and Christofori, Gerhard. (2014) Tead2 expression levels control Yap/Taz subcellular distribution, zyxin expression, and epithelial-mesenchymal transition. Journal of cell science, Vol. 127, H. 7. S. 1523-1536.

Braeutigam, C. and Rago, L. and Rolke, A. and Waldmeier, L. and Christofori, G. and Winter, J.. (2014) The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion. Oncogene, Vol. 33, H. 9. S. 1082-1092.

Fantozzi, Anna and Gruber, Dorothea C. and Pisarsky, Laura and Heck, Chantal and Kunita, Akiko and Yilmaz, Mahmut and Meyer-Schaller, Nathalie and Cornille, Karen and Hopfer, Ulrike and Bentires-Alj, Mohamed and Christofori, Gerhard. (2014) VEGF-mediated angiogenesis links EMT-induced cancer stemness to tumor initiation. Cancer research, Vol. 74, H. 5. S. 1566-1575.

Kuzmanov, Aleksandar and Hopfer, Ulrike and Marti, Patricia and Meyer-Schaller, Nathalie and Yilmaz, Mahmut and Christofori, Gerhard. (2014) LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling. Molecular oncology, Vol. 8, H. 2. S. 401-416.

Diepenbruck, Maren and Waldmeier, Lorenz and Ivanek, Robert and Berninger, Philipp and Arnold, Phil and van Nimwegen, Erik and Christofori, Gerhard. (2014) Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition. Journal of cell science, Vol. 127, H. 7. S. 1523-1536.


Tiwari, N. and Meyer-Schaller, N. and Arnold, P. and Antoniadis, H. and Pachkov, M. and van Nimwegen, E. and Christofori, G.. (2013) Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8). PLoS one, Vol. 8, H. 2 , e57329.

Tiwari, N. and Tiwari, V. K. and Waldmeier, L. and Balwierz, P. J. and Arnold, P. and Pachkov, M. and Meyer-Schaller, N. and Schubeler, D. and van Nimwegen, E. and Christofori, G.. (2013) Sox4 is a master regulator of epithelial-mesenchymal transition by controlling ezh2 expression and epigenetic reprogramming. Cancer cell, Vol. 23, H. 6. S. 768-783.

Albrecht, Imke and Bieri, Raphael and Leu, Angela and Granacher, Philipp and Hagmann, Jörg and Kilimann, Manfred W. and Christofori, Gerhard. (2013) Paralemmin-1 is expressed in lymphatic endothelial cells and modulates cell migration, cell maturation and tumor lymphangiogenesis. Angiogenesis, Vol. 16, H. 4. S. 795-807.

Fagiani, E. and Christofori, G.. (2013) Angiopoietins in angiogenesis. Cancer letters, Vol. 328, H. 1. S. 18-26.

Saxena, M. and Christofori, G.. (2013) Rebuilding cancer metastasis in the mouse. Molecular oncology, Vol. 7, H. 2. S. 283-296.

Chatterjee, S. and Heukamp, L. C. and Siobal, M. and Schottle, J. and Wieczorek, C. and Peifer, M. and Frasca, D. and Koker, M. and Konig, K. and Meder, L. and Rauh, D. and Buettner, R. and Wolf, J. and Brekken, R. A. and Neumaier, B. and Christofori, G. and Thomas, R. K. and Ullrich, R. T.. (2013) Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. Journal of clinical investigation, Vol. 123, H. 4. S. 1732-1740.

Saupe, F. and Schwenzer, A. and Jia, Y. and Gasser, I. and Spenle, C. and Langlois, B. and Kammerer, M. and Lefebvre, O. and Hlushchuk, R. and Rupp, T. and Marko, M. and van der Heyden, M. and Cremel, G. and Arnold, C. and Klein, A. and Simon-Assmann, P. and Djonov, V. and Neuville-Mechine, A. and Esposito, I. and Slotta-Huspenina, J. and Janssen, K. P. and de Wever, O. and Christofori, G. and Hussenet, T. and Orend, G.. (2013) Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model. Cell reports, Vol. 5, H. 2. S. 482-492.

Peier, M. and Walpen, T. and Christofori, G. and Battegay, E. and Humar, R.. (2013) Sprouty2 expression controls endothelial monolayer integrity and quiescence. Angiogenesis, Vol. 16, H. 2. S. 455-468.

Michaloglou, C. and Lehmann, W. and Martin, T. and Delaunay, C. and Hueber, A. and Barys, L. and Niu, H. and Billy, E. and Wartmann, M. and Ito, M. and Wilson, C. J. and Digan, M. E. and Bauer, A. and Voshol, H. and Christofori, G. and Sellers, W. R. and Hofmann, F. and Schmelzle, T.. (2013) The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity. PLoS one, Vol. 8, H. 4 , e61916.


Wicki, Andreas and Rochlitz, Christoph and Orleth, Annette and Ritschard, Reto and Albrecht, Imke and Herrmann, Richard and Christofori, Gerhard and Mamot, Christoph. (2012) Targeting tumor-associated endothelial cells: anti-VEGFR2 immunoliposomes mediate tumor vessel disruption and inhibit tumor growth. Clinical cancer research, Vol. 18, no. 18. S. 454-464.

Waldmeier, L. and Meyer-Schaller, N. and Diepenbruck, M. and Christofori, G.. (2012) Py2T murine breast cancer cells, a versatile model of TGFβ-induced EMT in vitro and in vivo. PLoS one, Vol. 7, H. 11 , e48651.

Zumsteg, Adrian and Caviezel, Christoph and Pisarsky, Laura and Strittmatter, Karin and García-Echeverría, Carlos and Hofmann, Francesco and Christofori, Gerhard. (2012) Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma. Molecular cancer research, Vol. 10, H. 6. S. 800-809.

Sleeman, J. P. and Christofori, G. and Fodde, R. and Collard, J. G. and Berx, G. and Decraene, C. and Ruegg, C.. (2012) Concepts of metastasis in flux : the stromal progression model. Seminars in cancer biology, Vol. 22, H. 3. S. 174-186.

Zumsteg, Adrian and Christofori, Gerhard. (2012) Myeloid cells and lymphangiogenesis. Cold Spring Harbor perspectives in medicine, Vol. 2, H. 6 , a006494.

Spano, D. and Heck, C. and De Antonellis, P. and Christofori, G. and Zollo, M.. (2012) Molecular networks that regulate cancer metastasis. Seminars in cancer biology, Vol. 22, H. 3. S. 234-249.

Tiwari, N. and Gheldof, A. and Tatari, M. and Christofori, G.. (2012) EMT as the ultimate survival mechanism of cancer cells. Seminars in cancer biology, Vol. 22, H. 3. S. 194-207.


Albrecht, Imke and Christofori, Gerhard. (2011) Molecular mechanisms of lymphangiogenesis in development and cancer. The International journal of developmental biology, Vol. 55, no. 4/5. S. 483-494.

Fendrich, V. and Rehm, J. and Waldmann, J. and Buchholz, M. and Christofori, G. and Lauth, M. and Slater, E. P. and Bartsch, D. K.. (2011) Hedgehog inhibition with cyclopamine represses tumor growth and prolongs survival in a transgenic mouse model of islet cell tumors. Annals of surgery, Vol. 253, H. 3. S. 546-552.

Yilmaz, M. and Maass, D. and Tiwari, N. and Waldmeier, L. and Schmidt, P. and Lehembre, F. and Christofori, G.. (2011) Transcription factor Dlx2 protects from TGFβ-induced cell-cycle arrest and apoptosis. The EMBO journal, Vol. 30, H. 21. S. 4489-4499.

Christofori, Gerhard. (2011) Metastatic colon cancer cells negotiate the intravasation notch. Cancer cell, Vol. 19, H. 1. S. 6-8.

Fagiani, E. and Lorentz, P. and Kopfstein, L. and Christofori, G.. (2011) Angiopoietin-1 and -2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis. Cancer research, Vol. 71, H. 17. S. 5717-5727.

Laurent, J. and Hull, E. F. and Touvrey, C. and Kuonen, F. and Lan, Q. and Lorusso, G. and Doucey, M. A. and Ciarloni, L. and Imaizumi, N. and Alghisi, G. C. and Fagiani, E. and Zaman, K. and Stupp, R. and Shibuya, M. and Delaloye, J. F. and Christofori, G. and Ruegg, C.. (2011) Proangiogenic factor PlGF programs CD11b(+) myelomonocytes in breast cancer during differentiation of their hematopoietic progenitors. Cancer research, Vol. 71,11. S. 3781-3791.


Bergmann, Astrid and Ahmad, Shakil and Cudmore, Melissa and Gruber, Achim D. and Wittschen, Petra and Lindenmaier, Werner and Christofori, Gerhard and Gross, Volkmar and Gonzalves, Andrey Ch da Costa and Gröne, Hermann-Josef and Ahmed, Asif and Weich, Herbert A.. (2010) Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model. Journal of cellular and molecular medicine, Vol. 14, H. 6B. S. 1857-1867.

Van de Veire, Sara and Stalmans, Ingeborg and Heindryckx, Femke and Oura, Hajimu and Tijeras-Raballand, Annemilaï and Schmidt, Thomas and Loges, Sonja and Albrecht, Imke and Jonckx, Bart and Vinckier, Stefan and Van Steenkiste, Christophe and Tugues, Sònia and Rolny, Charlotte and De Mol, Maria and Dettori, Daniela and Hainaud, Patricia and Coenegrachts, Lieve and Contreres, Jean-Olivier and Van Bergen, Tine and Cuervo, Henar and Xiao, Wei-Hong and Le Henaff, Carole and Buysschaert, Ian and Kharabi Masouleh, Behzad and Geerts, Anja and Schomber, Tibor and Bonnin, Philippe and Lambert, Vincent and Haustraete, Jurgen and Zacchigna, Serena and Rakic, Jean-Marie and Jiménez, Wladimiro and Noël, Agnes and Giacca, Mauro and Colle, Isabelle and Foidart, Jean-Michel and Tobelem, Gerard and Morales-Ruiz, Manuel and Vilar, José and Maxwell, Patrick and Vinores, Stanley A. and Carmeliet, Geert and Dewerchin, Mieke and Claesson-Welsh, Lena and Dupuy, Evelyne and Van Vlierberghe, Hans and Christofori, Gerhard and Mazzone, Massimiliano and Detmar, Michael and Collen, Désiré and Carmeliet, Peter. (2010) Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. Cell, Vol. 141, H. 1. S. 178-190.

Zumsteg, Adrian and Strittmatter, Karin and Klewe-Nebenius, Daniela and Antoniadis, Helena and Christofori, Gerhard. (2010) A bioluminescent mouse model of pancreatic {beta}-cell carcinogenesis. Carcinogenesis, Vol. 31, H. 8. S. 1465-1474.

Grotegut, S. and Kappler, R. and Tarimoradi, S. and Lehembre, F. and Christofori, G. and Von Schweinitz, D.. (2010) Hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by AKT activation. International journal of oncology, Vol. 36, H. 5. S. 1261-1267.

Albrecht, Imke and Kopfstein, Lucie and Strittmatter, Karin and Schomber, Tibor and Falkevall, Annelie and Hagberg, Carolina E. and Lorentz, Pascal and Jeltsch, Michael and Alitalo, Kari and Eriksson, Ulf and Christofori, Gerhard and Pietras, Kristian. (2010) Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis. PLoS one, Vol. 5, H. 11 , e14109.

Christofori, Gerhard. (2010) Snail1 links transcriptional control with epigenetic regulation. The EMBO journal, Vol. 29, H. 11. S. 1787-1789.

Wild, Damian and Wicki, Andreas and Mansi, Rosalba and Béhé, Martin and Keil, Boris and Bernhardt, Peter and Christofori, Gerhard and Ell, Peter J. and Mäcke, Helmut R.. (2010) Exendin-4-based radiopharmaceuticals for glucagonlike peptide-1 receptor PET/CT and SPECT/CT. Journal of nuclear medicine, Vol. 51, H. 7. S. 1059-1067.

Wicki, Andreas and Herrmann, Richard and Christofori, Gerhard. (2010) Kras in metastatic colorectal cancer. Swiss Medical Weekly, Vol. 140 , w13112.

Yilmaz, Mahmut and Christofori, Gerhard. (2010) Mechanisms of motility in metastasizing cells. Molecular Cancer Research, Vol. 8. S. 629-642.


Francavilla, Chiara and Cattaneo, Paola and Berezin, Vladimir and Bock, Elisabeth and Ami, Diletta and de Marco, Ario and Christofori, Gerhard and Cavallaro, Ugo. (2009) The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking. Journal of cell biology, Vol. 187. S. 1101-1116.

Zumsteg, A. and Christofori, G.. (2009) Corrupt policemen : inflammatory cells promote tumor angiogenesis. Current opinion in oncology : review articles, recommended reading, bibliography of the world literature, Vol. 21. S. 60-70.

Andrés, Germán and Leali, Daria and Mitola, Stefania and Coltrini, Daniela and Camozzi, Maura and Corsini, Michela and Belleri, Mirella and Hirsch, Emilio and Schwendener, Reto A. and Christofori, Gerhard and Alcamí, Antonio and Presta, Marco. (2009) A pro-inflammatory signature mediates FGF2-induced angiogenesis. Journal of cellular and molecular medicine : an international journal, Vol. 13. S. 2083-108.

Zumsteg, Adrian and Baeriswyl, Vanessa and Imaizumi, Natsuko and Schwendener, Reto and Rüegg, Curzio and Christofori, Gerhard. (2009) Myeloid cells contribute to tumor lymphangiogenesis. PLoS one, Vol. 4 , e7067.

Tremmel, Martina and Matzke, Alexandra and Albrecht, Imke and Laib, Anna M. and Olaku, Vivienne and Ballmer-Hofer, Kurt and Christofori, Gerhard and Héroult, Mélanie and Augustin, Hellmut G. and Ponta, Helmut and Orian-Rousseau, Véronique. (2009) A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis. Blood : the journal of the American Society of Hematology, Vol. 114. S. 5236-5244.

Baeriswyl, Vanessa and Christofori, Gerhard. (2009) The angiogenic switch in carcinogenesis. Seminars in cancer biology, Vol. 19, H. 7. S. 329-337.

Schomber, T. and Zumsteg, A. and Strittmatter, K. and Crnic, I. and Antoniadis, H. and Littlewood-Evans, A. and Wood, J. and Christofori, G.. (2009) Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis. Molecular cancer therapeutics, Vol. 8. S. 55-63.

Yilmaz, Mahmut and Christofori, Gerhard. (2009) EMT, the cytoskeleton, and cancer cell invasion. Cancer and metastasis reviews, Vol. 28, H. 1-2. S. 15-33.


Sobczak, I. and Galabova-Kovacs, G. and Sadzak, I. and Kren, A. and Christofori, G. and Baccarini, M.. (2008) B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis. Oncogene, Vol. 27. S. 4779-4787.

Jäggi, F. and Cabrita, M. A. and Perl, A. K. and Christofori, G.. (2008) Modulation of endocrine pancreas development but not beta-cell carcinogenesis by Sprouty4. Molecular Cancer Research, Vol. 6. S. 468-482.

Lehembre, F. and Yilmaz, M. and Wicki, A. and Schomber, T. and Strittmatter, K. and Ziegler, D. and Kren, A. and Went, P. and Derksen, P. W. and Berns, A. and Jonkers, J. and Christofori, G.. (2008) NCAM-induced focal adhesion assembly : a functional switch upon loss of E-cadherin. The EMBO journal, Vol. 27, H. 9. S. 2603-2615.

Tammela, T. and Zarkada, G. and Wallgard, E. and Murtomäki, A. and Suchting, S. and Wirzenius, M. and Waltari, M. and Hellström, M. and Schomber, T. and Peltonen, R. and Freitas, C. and Duarte, A. and Isoniemi, H. and Laakkonen, P. and Christofori, G. and Ylä-Herttuala, S. and Shibuya, M. and Pytowski, B. and Eichmann, A. and Betsholtz, C. and Alitalo, K.. (2008) Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature, Vol. 454, H. 7204. S. 656-660.

Cabrita, M. A. and Christofori, G.. (2008) Sprouty proteins, masterminds of receptor tyrosine kinase signaling. Angiogenesis, Vol. 11, H. 1. S. 53-62.