In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein

Franchini, Genoveffa

doi:10.1182/blood-2008-04-146928

In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein

Date Issued

2009-01-01

Author(s)

Fukumoto, Risaku

Andresen, Vibeke

Bialuk, Izabela

Cecchinato, Valentina

Walser, Jean-Claude

Valeri, Valerio W.

Nauroth, Julie M.

Gessain, Antoine

Nicot, Christophe

Franchini, Genoveffa

DOI

10.1182/blood-2008-04-146928

Abstract

The human T-cell leukemia/lymphoma virus type 1 (HTLV-1) ORF-I encodes a 99-amino acid hydrophobic membrane protein, p12 I , that affects receptors in different cellular compartments. We report here that proteolytic cleavage