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Semantic and phonemic sequence effects in random word generation : a dissociation between Alzheimer's and Huntington's disease patients

Taylor, Kirsten I. and Salmon, David P. and Monsch, Andreas U. and Brugger, Peter. (2005) Semantic and phonemic sequence effects in random word generation : a dissociation between Alzheimer's and Huntington's disease patients. Journal of the International Neuropsychological Society, Vol. 11, H. 3. S. 303-310.

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Official URL: http://edoc.unibas.ch/dok/A5250785

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Abstract

Alzheimer's disease (AD) patients perform worse on category than letter fluency tasks, while Huntington's disease (HD) patients show the reverse pattern or comparable impairment on both tasks. We developed a random word generation task to further investigate these deficits. Twenty AD and 16 HD patients and 20 elderly and 16 middle-aged controls guessed which of three pictures (hat, cat, or dog) landed on a die's top face sixty times. Three consecutive response pairings were possible: semantic (cat-dog), phonemic (hat-cat), and neutral (hat-dog). Since healthy individuals avoid repeating meaningful associates ("repetition avoidance"), an increased pairing frequency reflects processing deficits. AD patients produced more semantic and HD patients more phonemic pairings compared to their respective control groups, indicating selective semantic and phonemic processing deficits in AD and HD patients, respectively.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Geriatrie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Geriatrie
07 Faculty of Psychology > Departement Psychologie
UniBasel Contributors:Monsch, Andreas U
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Cambridge Univ. Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Sep 2015 14:31
Deposited On:22 Mar 2012 13:47

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