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Aging enhances the calcium sensitivity of central neurons of the mouse as an adaptive response to reduced free intracellular calcium

Hartmann, H. and Eckert, A. and Müller, W. E.. (1993) Aging enhances the calcium sensitivity of central neurons of the mouse as an adaptive response to reduced free intracellular calcium. Neuroscience letters, Vol. 152, H. 1-2. S. 181-184.

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Official URL: http://edoc.unibas.ch/dok/A5253526

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Abstract

Age-related changes in Ca(2+)-homeostasis have been investigated in mechanically dissociated neurons from young and aged mice. In aged animals, basal intracellular calcium ([Ca2+]i) was significantly reduced and depolarization (KCl)-induced rise in [Ca2+]i was lower, probably as a result of increased activation of Ca(2+)-dependent mechanisms terminating Ca2+ influx. Additionally, depolarization-induced inositol-phosphate (IP) accumulation in aged animals was found to be significantly increased. Both findings suggest that Ca(2+)-dependent intracellular processes become more sensitive to Ca2+ in aged animals due to decreased Ca2+ availability.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
UniBasel Contributors:Eckert, Anne
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Elsevier/North-Holland
ISSN:0304-3940
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:40

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