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Inhibition of taurocholate efflux from rat hepatic canalicular membrane vesicles by glutathione disulfide

Griffiths, J. C. and Sies, H. and Meier, P. J. and Akerboom, T. P.. (1987) Inhibition of taurocholate efflux from rat hepatic canalicular membrane vesicles by glutathione disulfide. FEBS letters, Vol. 213, H. 1. S. 34-38.

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Official URL: http://edoc.unibas.ch/dok/A5261797

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Abstract

In right-side out rat hepatic canalicular membrane vesicles glutathione disulfide (GSSG) inhibited the efflux of taurocholate approx. 70% in the presence or approx. 55% in the absence of a valinomycin-mediated K+ diffusion potential; maximal inhibition occurred at 5 mM GSSG. The inhibition by GSSG was abolished by dithioerythritol. Neither dithioerythritol alone nor GSH inhibited taurocholate efflux. S-(2,4-Dinitrophenyl)glutathione and N-ethylmaleimide showed intermediate inhibitory effects.
Faculties and Departments:11 Rektorat und Verwaltung > Vizerektorat Forschung
UniBasel Contributors:Meier-Abt, Peter J.
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Elsevier Science
ISSN:0014-5793
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:35

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