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The amplifying effect of beta-amyloid on cellular calcium signalling is reduced in Alzheimer's disease.

Eckert, A. and Förstl, H. and Hartmann, H. and Czech, C. and Mönning, U. and Beyreuther, K. and Müller, W. E.. (1995) The amplifying effect of beta-amyloid on cellular calcium signalling is reduced in Alzheimer's disease. NeuroReport, Vol. 6, H. 8. S. 1199-1202.

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Official URL: http://edoc.unibas.ch/dok/A5253515

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Abstract

The amplifying effect of beta-amyloid fragment 25-35 (beta A25-35) on the mitogen-induced rise of free intracellular calcium in circulating lymphocytes was strongly reduced in 24 patients with Alzheimer's disease when compared with elderly, non-demented controls. Low beta-amyloid responses were significantly correlated with the presence of the apolipoprotein E epsilon 4 allele, suggesting a dose effect.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
UniBasel Contributors:Eckert, Anne
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Lippincott Williams & Wilkins
ISSN:0959-4965
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:35

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