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Pathophysiology and pharmacology of GABA(A) receptors

Möhler, H. and Fritschy, J. M. and Vogt, K. and Crestani, F. and Rudolph, U.. (2005) Pathophysiology and pharmacology of GABA(A) receptors. Handbook of Experimental Pharmacology, H. 169. S. 225-247.

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Official URL: http://edoc.unibas.ch/dok/A5259784

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Abstract

By controlling spike timing and sculpting neuronal rhythms, inhibitory interneurons play a key role in brain function. GABAergic interneurons are highly diverse. The respective GABA(A) receptor subtypes, therefore, provide new opportunities not only for understanding GABA-dependent pathophysiologies but also for targeting of selective neuronal circuits by drugs. The pharmacological relevance of GABA(A) receptor subtypes is increasingly being recognized. A new central nervous system pharmacology is on the horizon. The development of anxiolytic drugs devoid of sedation and of agents that enhance hippocampus-dependent learning and memory has become a novel and highly selective therapeutic opportunity.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Vogt)
UniBasel Contributors:Vogt, Kaspar
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Springer
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:04 Sep 2015 14:31
Deposited On:22 Mar 2012 13:31

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