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A simple adult-mouse test for tissue invasiveness in Yersinia enterocolitica strains of low experimental virulence

Bakour, R. and Balligand, G. and Laroche, Y. and Cornelis, G. and Wauters, G.. (1985) A simple adult-mouse test for tissue invasiveness in Yersinia enterocolitica strains of low experimental virulence. The Journal of Medical Microbiology, Vol. 19, H. 2. S. 237-246.

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Official URL: http://edoc.unibas.ch/dok/A5259270

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Abstract

The virulence of Yersinia enterocolitica depends on the presence of a 70-kilobase plasmid, called the Vwa plasmid. This situation is particularly favourable for studies of the mechanism of pathogenicity, but these are hindered by the lack of a suitable animal test to monitor the virulence of the human-pathogenic strains isolated outside the USA which belong to serogroups O:3, O:9 and O:5,27. We observed that, after oral administration to the mouse, the Vwa-positive strains of these serogroups produce a discrete systemic infection while the Vwa-negative strains do not. We present here a simple mouse-virulence test based on this observation.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Molecular Microbiology (Cornelis)
UniBasel Contributors:Cornelis, Guy R.
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Pathological Society of Great Britain and Ireland
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:22
Deposited On:22 Mar 2012 13:31

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