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Heterogeneity of obesity-asthma association disentangled by latent class analysis, the SAPALDIA cohort

Jeong, Ayoung and Imboden, Medea and Hansen, Sofie and Zemp, Elisabeth and Bridevaux, Pierre-Olivier and Lovison, Gianfranco and Schindler, Christian and Probst-Hensch, Nicole. (2017) Heterogeneity of obesity-asthma association disentangled by latent class analysis, the SAPALDIA cohort. Respiratory medicine, 125. pp. 25-32.

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Official URL: http://edoc.unibas.ch/55418/

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Abstract

Although evidence for the heterogeneity of asthma accumulated, consensus for definitions of asthma phenotypes is still lacking. Obesity may have heterogeneous effects on various asthma phenotypes. We aimed to distinguish asthma phenotypes by latent class analysis and to investigate their associations with different obesity parameters in adults using a population-based Swiss cohort (SAPALDIA). We applied latent class analysis to 959 self-reported asthmatics using information on disease activity, atopy, and age of onset. Associations with obesity were examined by multinomial logistic regression, after adjustments for age, sex, smoking status, educational level, and study centre. Body mass index, percent body fat, waist hip ratio, waist height ratio, and waist circumference were used as obesity measure. Four asthma classes were identified, including persistent multiple symptom-presenting asthma (n = 122), symptom-presenting asthma (n = 290), symptom-free atopic asthma (n = 294), and symptom-free non-atopic asthma (n = 253). Obesity was positively associated with symptom-presenting asthma classes but not with symptom-free ones. Percent body fat showed the strongest association with the persistent multiple symptom-presenting asthma. We observed heterogeneity of associations with obesity across asthma classes, indicating different asthma aetiologies.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Imboden, Medea and Zemp Stutz, Elisabeth and Schindler, Christian and Probst Hensch, Nicole
Item Type:Article, refereed
Publisher:Saunders
ISSN:0954-6111
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:14 Jun 2017 14:28
Deposited On:14 Jun 2017 14:28

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