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Defining the next generation of Plasmodium vivax diagnostic tests for control and elimination : target product profiles

Ding, Xavier C. and Ade, Maria Paz and Baird, J. Kevin and Cheng, Qin and Cunningham, Jane and Dhorda, Mehul and Drakeley, Chris and Felger, Ingrid and Gamboa, Dionicia and Harbers, Matthias and Herrera, Socrates and Lucchi, Naomi and Mayor, Alfredo and Mueller, Ivo and Sattabongkot, Jetsumon and Ratsimbason, Arsène and Richards, Jack and Tanner, Marcel and González, Iveth J.. (2017) Defining the next generation of Plasmodium vivax diagnostic tests for control and elimination : target product profiles. PLoS Neglected Tropical Diseases, 11 (4). e0005516.

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Official URL: http://edoc.unibas.ch/55381/

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Abstract

The global prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical attacks without involving another mosquito bite. The diagnosis of acute patent P. vivax malaria relies primarily on light microscopy. Specific rapid diagnostic tests exist but typically perform relatively poorly compared to those for P. falciparum. Better diagnostic tests are needed for P. vivax. To guide their development, FIND, in collaboration with P. vivax experts, identified the specific diagnostic needs associated with this species and defined a series of three distinct target product profiles, each aimed at a particular diagnostic application: (i) point-of-care of acutely ill patients for clinical care purposes; (ii) point-of-care asymptomatic and otherwise sub-patent residents for public health purposes, e.g., mass screen and treat campaigns; and (iii) ultra-sensitive not point-of-care diagnosis for epidemiological research/surveillance purposes. This report presents and discusses the rationale for these P. vivax-specific diagnostic target product profiles. These contribute to the rational development of fit-for-purpose diagnostic tests suitable for the clinical management, control and elimination of P. vivax malaria.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Diagnostics (Felger)
UniBasel Contributors:Felger, Ingrid
Item Type:Article, refereed
Publisher:Public Library of Science
ISSN:1935-2727
e-ISSN:1935-2735
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:14 Jun 2017 14:05
Deposited On:14 Jun 2017 14:05

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