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Characterization of new Functionalized Calcium Carbonate-Polycaprolactone Composite Material for Application in Geometry-constrained Drug Release Formulation Development

Wagner-Hattler, Leonie and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2017) Characterization of new Functionalized Calcium Carbonate-Polycaprolactone Composite Material for Application in Geometry-constrained Drug Release Formulation Development. Drug Development and Industrial Pharmacy, 43 (10). pp. 1669-1676.

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Official URL: http://edoc.unibas.ch/55115/

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Abstract

A new mineral-polymer composite (FCC-PCL) performance is assessed to produce complex geometries to aid in development of controlled release tablet formulations. The mechanical characteristics of a developed material such as compactibility, compressibility and elastoplastic deformation were measured. The results and comparative analysis versus other common excipients suggest efficient formation of a complex, stable and impermeable geometries for constrained drug release modifications under compression. The performance of the proposed composite material has been tested by compacting it into a geometrically altered tablet (Tablet-In-Cup, TIC) and the drug release was compared to commercially available product. The TIC device exhibited a uniform surface, showed high physical stability, and showed absence of friability. FCC-PCL composite had good binding properties and good compactibility. It was possible to reveal an enhanced plasticity characteristic of a new material which was not present in the individual components. The presented FCC-PCL composite mixture has the potential to become a successful tool to formulate controlled-release dosage solid forms.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Technologie (Huwyler)
UniBasel Contributors:Huwyler, Jörg and Wagner-Hattler, Leonie and Puchkov, Maxim
Item Type:Article, refereed
Publisher:Taylor & Francis
ISSN:0363-9045
e-ISSN:1520-5762
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Oct 2017 09:44
Deposited On:19 Oct 2017 09:44

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