edoc

Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design

Cai, Xiaofeng and Nowak, Sarah and Wesche, Frank and Bischoff, Iris and Kaiser, Marcel and Fürst, Robert and Bode, Helge B.. (2017) Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design. Nature Chemistry, 9 (4). pp. 379-386.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/55075/

Downloads: Statistics Overview

Abstract

The production of natural product compound libraries has been observed in nature for different organisms such as bacteria, fungi and plants; however, little is known about the mechanisms generating such chemically diverse libraries. Here we report mechanisms leading to the biosynthesis of the chemically diverse rhabdopeptide/xenortide peptides (RXPs). They are exclusively present in entomopathogenic bacteria of the genera Photorhabdus and Xenorhabdus that live in symbiosis with nematodes delivering them to insect prey, which is killed and utilized for nutrition by both nematodes and bacteria. Chemical diversity of the biologically active RXPs results from a combination of iterative and flexible use of monomodular nonribosomal peptide synthetases including substrate promiscuity, enzyme cross-talk and enzyme stoichiometry as shown by in vivo and in vitro experiments. Together, this highlights several of nature's methods for diversification, or evolution, of natural products and sheds light on the biosynthesis of the bioactive RXPs.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Publisher:Nature
ISSN:1755-4330
e-ISSN:1755-4349
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:29 May 2017 13:44
Deposited On:29 May 2017 13:44

Repository Staff Only: item control page