Merlo, Adrian and Bettler, Bernhard. (2004) Glioblastomas on the move. Science's STKE, Vol. 2004, no. 229 , pe18.
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Official URL: http://edoc.unibas.ch/dok/A5262249
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Abstract
The mechanism by which the tumor suppressor PTEN slows tumor cell migration is not well characterized. A recent study by Raftopoulou et al. shows that a lack of PTEN protein phosphatase activity accelerates the migration of glioblastoma cells. The protein phosphatase activity of PTEN is directly or indirectly responsible for dephosphorylating a PTEN residue, threonine-383, which is necessary for slowing cell migration. These findings have implications for the design of new therapies against glioblastomas and other highly invasive cancers.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Molecular Neurobiology Synaptic Plasticity (Bettler) |
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| UniBasel Contributors: | Bettler, Bernhard |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Science |
| ISSN: | 1525-8882 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
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| Last Modified: | 22 Mar 2012 14:22 |
| Deposited On: | 22 Mar 2012 13:30 |
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