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The effects of growing up on a farm on adult lung function and allergic phenotypes : an international population-based study

Campbell, B. and Raherison, C. and Lodge, C. J. and Lowe, A. J. and Gislason, T. and Heinrich, J. and Sunyer, J. and Gómez Real, F. and Norbäck, D. and Matheson, M. C. and Wjst, M. and Dratva, J. and de Marco, R. and Jarvis, D. and Schlünssen, V. and Janson, C. and Leynaert, B. and Svanes, C. and Dharmage, S. C.. (2017) The effects of growing up on a farm on adult lung function and allergic phenotypes : an international population-based study. Thorax, 72 (3). pp. 236-244.

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Official URL: http://edoc.unibas.ch/54724/

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Abstract

Evidence has suggested that exposure to environmental or microbial biodiversity in early life may impact subsequent lung function and allergic disease risk.; To investigate the influence of childhood living environment and biodiversity indicators on atopy, asthma and lung function in adulthood.; The European Community Respiratory Health Survey II investigated ∼10 201 participants aged 26-54 years from 14 countries, including participants' place of upbringing (farm, rural environment or inner city) before age 5 years. A 'biodiversity score' was created based on childhood exposure to cats, dogs, day care, bedroom sharing and older siblings. Associations with lung function, bronchial hyper-responsiveness (BHR), allergic sensitisation, asthma and rhinitis were analysed.; As compared with a city upbringing, those with early-life farm exposure had less atopic sensitisation (adjusted OR 0.46, 95% CI 0.37 to 0.58), atopic BHR (0.54 (0.35 to 0.83)), atopic asthma (0.47 (0.28 to 0.81)) and atopic rhinitis (0.43 (0.32 to 0.57)), but not non-atopic outcomes. Less pronounced protective effects were observed for rural environment exposures. Women with a farm upbringing had higher FEV1 (adjusted difference 110 mL (64 to 157)), independent of sensitisation and asthma. In an inner city environment, a higher biodiversity score was related to less allergic sensitisation.; This is the first study to report beneficial effects of growing up on a farm on adult FEV1. Our study confirmed the beneficial effects of early farm life on sensitisation, asthma and rhinitis, and found a similar association for BHR. In persons with an urban upbringing, a higher biodiversity score predicted less allergic sensitisation, but to a lesser magnitude than a childhood farm environment.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
UniBasel Contributors:Dratva, Julia
Item Type:Article, refereed
Publisher:British Medical Association
ISSN:0040-6376
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 May 2017 09:24
Deposited On:23 May 2017 09:24

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