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The adverse impact of obesity on heart rate variability is modified by a NFE2L2 gene variant : the SAPALDIA cohort

Adam, Martin and Imboden, Medea and Schaffner, Emmanuel and Boes, Eva and Kronenberg, Florian and Pons, Marco and Bettschart, Robert and Barthelemy, Jean-Claude and Schindler, Christian and Probst-Hensch, Nicole. (2017) The adverse impact of obesity on heart rate variability is modified by a NFE2L2 gene variant : the SAPALDIA cohort. International journal of cardiology, 228. pp. 341-346.

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Official URL: http://edoc.unibas.ch/54361/

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Abstract

Overweight has been associated with an increase in inflammatory markers and with an imbalance in the autonomic nervous system, such as a decrease in heart rate variability (HRV). In this study we aimed to investigate the modifying effect of a genetic variation in a major anti-inflammatory marker gene, NFE2L2, on the relationship between overweight and HRV.; We analyzed participants of the SAPALDIA cohort aged 50years and older, twice in 2002/2003 (N=1472) and 2010/2011 (N=1235). We included persons with valid genotype data, who underwent ambulatory 24-h electrocardiogram monitoring, and reported on medical history and lifestyle. The association between HRV and BMI, measured as standard deviation of normal-to-normal intervals (SDNN) by BMI and the modifying effect of the cardiovascular health-related NFE2L2 gene variant rs2364723 were tested, applying multivariable mixed linear regression models.; We found study participants with overweight (BMI>25) over two follow-up surveys 10years apart to have a negative association between SDNN, calculated as geometric means, with BMI. The examined NFE2L2 variant sustainably modified (pinteraction=0.014) the found inverse association between a BMI increment and SDNN, causing a stronger decrement in SDNN for participants with the CC genotype (-20.7%; 95%-confidence interval: -12.33 to -28.28) compared with participants carrying the GC (-7.43; 95%CI: -3.56 to -11.15) or GG (-11.26%; 95%CI: -7.68 to -14.7) genotype, estimated for the difference from the 90(th) to the 10(th) percentile of BMI by the NFE2L2 variant.; Our results are consistent with the hypothesis that overweight decreases heart rate variability through inflammatory processes.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
UniBasel Contributors:Adam, Martin and Imboden, Medea and Schaffner, Emmanuel and Schindler, Christian and Probst Hensch, Nicole
Item Type:Article, refereed
Publisher:Excerpta medica
ISSN:0167-5273
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:24 Apr 2017 12:11
Deposited On:24 Apr 2017 12:11

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