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MASDET-A fast and user-friendly multiplatform software for mass determination by dark-field electron microscopy

Krzyzanek, V. and Müller, S. A. and Engel, A. and Reichelt, R.. (2009) MASDET-A fast and user-friendly multiplatform software for mass determination by dark-field electron microscopy. Journal of structural biology, Vol. 165, H. 2. pp. 78-87.

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Official URL: http://edoc.unibas.ch/dok/A5262455

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Abstract

Electron microscopy has been used to measure the mass of biological nanoparticles since the early 60s, and is the only way to obtain the mass of large structures or parameters such as the mass-per-length of filaments. The ability of this method to sort heterogeneous samples both in terms of mass and shape promises to make it a key tool for proteomics down to the single cell level. A new multiplatform software package, MASDET, that can be run under MATLAB or as a standalone program is described. Based on a user-friendly graphical interface MASDET streamlines mass evaluation and greatly increases the speed of required optimisation procedures. Importantly, the immediate application of Monte-Carlo simulations to describe multiple scattering is possible, allowing the mass analysis of thicker samples and the generation of mass thickness maps.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Engel)
UniBasel Contributors:Engel, Andreas H and Müller, Shirley
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Academic Press
ISSN:1047-8477
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:01 Mar 2013 11:06
Deposited On:22 Mar 2012 13:30

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