Reichenberg, Armin and Hintz, Martin and Kletschek, Yvonne and Kuhl, Tanja and Haug, Christian and Engel, Rosel and Moll, Jens and Ostrovsky, Dmitry N. and Jomaa, Hassan and Eberl, Matthias. (2003) Replacing the pyrophosphate group of HMB-PP by a diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism. Bioorganic and Medicinal Chemistry Letters, 13 (7). pp. 1257-1260.
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Abstract
The immunological characterization of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), and its methylenediphosphonate analogue, HMB-PCP, is described. With an EC(50) of 0.1-0.2 nM, HMB-PP is significantly more potent in stimulating human Vgamma9/Vdelta2 T cells than any other compound described so far. However, replacing the pyrophosphate by a P-CH(2)-P function abrogates the bioactivity drastically, with HMB-PCP having a EC(50) of only 5.3 microM.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Anästhesie (Frei/Erb) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Anästhesie (Frei/Erb) |
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| UniBasel Contributors: | Moll, Jens |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 0960-894X |
| e-ISSN: | 1464-3405 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 23 Nov 2017 10:32 |
| Deposited On: | 23 Nov 2017 10:32 |
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